Drug & supplement interaction

Squalamine + Colesevelam

Colesevelam brand names: WelChol, Lodalis.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Colesevelam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Colesevelam states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Squalamine and Colesevelam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Colesevelam and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Colesevelam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Colesevelam and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Squalamine and Colesevelam May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Muscle pain reported in 8.1% of FDA reports for Colesevelam Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate myalgias and muscle cramps in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in muscle cramps.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colesevelam

    Listed in the ADVERSE REACTIONS section of the FDA label for Colesevelam, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Tiredness Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colesevelam

    Listed in the ADVERSE REACTIONS section of the FDA label for Colesevelam. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Squalamine

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

    Colesevelam

    Listed in the ADVERSE REACTIONS section of the FDA label for Colesevelam. Read the label on DailyMed ›

Reported for Squalamine but not commonly for Colesevelam: yellowing of the skin or eyes, reduced appetite and liver problems.

Effects for Colesevelam come from the ADVERSE REACTIONS section of its FDA label; effects for Squalamine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,014 voluntary FDA FAERS reports for Colesevelam that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Colesevelam Products Have a Food Rule — Squalamine Should Not Break It

At least one FDA label for a product containing Colesevelam says to take it with food. If you take Squalamine on an empty stomach out of habit, keep them separate — and take Colesevelam with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Colesevelam products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Colesevelam hydrochloride should be taken as follows ( 2.2 , 2.4 ): Tablets Take 6 tablets once daily or 3 tablets twice daily with a meal and liquid.

From the Dosage and Administration section of the FDA label we read for Colesevelam — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Squalamine or Colesevelam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Squalamine or Colesevelam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Colesevelam

This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Colesevelam page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Colesevelam page

“Colesevelam (WelChol, Lodalis) lowers cholesterol by binding bile acids in your gut, and every one of the 17 supplements on this list can interfere with how oral medicines are absorbed in that same territory. I would treat this list with genuine care, and the place to start is activated charcoal, the only major-rated entry.”

Reviewed by 2 · Jul 18, 2026

Open the Colesevelam interaction page

How much people look this up

Where Squalamine and Colesevelam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#956 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Colesevelam
Steady interest

#2,234 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Squalamine and Colesevelam records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Medication

About Colesevelam

What Is Colesevelam Used For?

Brand names: WelChol, Lodalis

Colesevelam is used alongside diet and exercise to reduce high LDL cholesterol (the "bad" cholesterol) in adults with primary hyperlipidemia (high cholesterol). It is also approved to lower LDL cholesterol in boys and girls aged 10–17 who have heterozygous familial hypercholesterolemia (HeFH) — an inherited condition that causes very high cholesterol — when diet and lifestyle changes alone haven't worked.

Colesevelam tablets and oral suspension (Welchol and colesevelam hydrochloride products) are also used to improve blood sugar control in adults with type 2 diabetes, as an add-on to diet and exercise. Colesevelam is not for type 1 diabetes or diabetic ketoacidosis.

Most-Reported Side Effects for Colesevelam

From FAERS, the FDA’s public side-effect reporting system (2,014 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 241 reports
Dyspnea 172 reports
Cough 169 reports
Muscle spasms 163 reports
Nasopharyngitis 150 reports
See full Colesevelam drug information
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Colesevelam, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Colesevelam Together: Common Questions

Is it safe to take Squalamine with Colesevelam?
We do not list a known interaction between Squalamine and Colesevelam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Squalamine and Colesevelam have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Squalamine and Colesevelam at the same time of day?
At least one FDA label for a product containing Colesevelam says to take it with food. If you take Squalamine on an empty stomach out of habit, keep them separate and take Colesevelam with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Colesevelam products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Colesevelam interact with any supplements?
Yes. Colesevelam has documented interactions with 17 supplements in our database — Squalamine is not one of them. The Colesevelam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Colesevelam drug information The full plain-English guide to this medication Colesevelam supplement interactions Every supplement checked against Colesevelam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Colesevelam and Squalamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.