Drug & supplement interaction

Squalamine + Mechlorethamine Hydrochloride

Mechlorethamine Hydrochloride brand name: Valchlor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Squalamine and Mechlorethamine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Squalamine and Mechlorethamine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mechlorethamine Hydrochloride and Squalamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Squalamine at all — not against Mechlorethamine Hydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Squalamine safety at a glance

Squalamine overall Not established Squalamine has mainly been studied in research settings, and its safety as a self-care supplement is not established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid using it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mechlorethamine Hydrochloride and Squalamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Squalamine Itself Has Been Linked To

This is not an interaction — nothing below involves Mechlorethamine Hydrochloride. It is the side-effect record for Squalamine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Squalamine, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Intravenously, squalamine at doses above 192 mg/m2 daily has been associated with reports of elevated hepatic transaminase levels. Levels of aspartate aminotransferase and alanine aminotransferase were about 5 to over 20 times above upper normal levels in some patients. The increased levels were noted 2-5 days after beginning squalamine. Both values returned to baseline within 6-23 days.”

    Squalamine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.
  • Liver problems Worth acting on Additional detail

    “Topically and intravenously, squalamine seems to be well tolerated; however, a thorough safety evaluation has not been conducted.

    Most Common Adverse Effects:

    Intravenously: Fatigue, loss of appetite, myalgia, nausea, transaminitis, vomiting.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

  • Reduced appetite / Vomiting / Nausea Additional detail

    “Intravenously, squalamine has been associated with reports of mild to moderate nausea and vomiting, as well as mild loss of appetite, in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.
  • Muscle pain Additional detail

    “Intravenously, squalamine has been associated with reports of mild to moderate myalgias and muscle cramps in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in muscle cramps.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.
  • Tiredness Additional detail

    “Intravenously, squalamine has been associated with reports of mild to moderate fatigue in clinical research.”

    Squalamine · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 96040. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Everything above comes from the Natural Medicines adverse-effect record for Squalamine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Mechlorethamine Hydrochloride’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Mechlorethamine Hydrochloride column appears here.

From our Q&A

Questions About Squalamine or Mechlorethamine Hydrochloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Squalamine or Mechlorethamine Hydrochloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mechlorethamine Hydrochloride

This page covers Squalamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mechlorethamine Hydrochloride page lists 10 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate), Dimethylsulfoxide (dmso) (moderate) and Rose Hip (moderate).

By severity: 9 moderate · 1 minor.

From our pharmacist’s overview on the Mechlorethamine Hydrochloride page

“Mechlorethamine (Valchlor) is a chemotherapy gel applied to the skin for a form of lymphoma, and the 10 supplements on this page split into two groups. Seven are antioxidants, everyday products like vitamin C and turmeric, which in theory could blunt how well an alkylating chemotherapy drug works.”

Reviewed by 2 · Jul 18, 2026

Open the Mechlorethamine Hydrochloride interaction page

How much people look this up

Where Squalamine and Mechlorethamine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Squalamine
Steady interest

#843 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mechlorethamine Hydrochloride
Steady interest

#2,517 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Squalamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Squalamine and Mechlorethamine Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Squalamine

What is Squalamine?

  • Cancer (investigational)
  • Age-related macular degeneration (eye disease)
  • Antimicrobial / antiviral interest
  • Anti-angiogenesis (blocking new blood vessel growth)

Squalamine is a compound first found in the dogfish shark that has mainly been studied as an experimental drug, not as a common dietary supplement. Research has looked at it for cancer and certain eye diseases, but evidence in people is limited and it is not an approved or widely available treatment. Talk to your doctor or pharmacist before using any product claiming to contain it.

Originally isolated from the liver and tissues of the dogfish shark (Squalus acanthias); also made synthetically · Investigational drug forms (intravenous infusion, eye drops); not a typical over-the-counter dietary supplement

An interaction check asks whether these two react with each other — it does not ask whether Squalamine is a good idea for someone in your situation. Here is what our Squalamine record says about it on its own.

Squalamine: dosing

There is no established or standardized dose of squalamine for use as a dietary supplement. Keep in mind that supplement quality and labeling are not always reliable, and a pharmacist can help you decide whether using such a product makes sense for you.

From our Squalamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Squalamine monograph & all interactions
Medication

About Mechlorethamine Topical

What Is Mechlorethamine Topical Used For?

Brand name: Valchlor

Valchlor (mechlorethamine gel applied to the skin) is approved to treat Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma — a slow-growing cancer that primarily affects the skin. It is used in patients who have already received at least one prior skin-directed treatment.

Most-Reported Side Effects for Mechlorethamine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (2,244 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 322 reports
Application site pruritus 224 reports
Application site erythema 220 reports
Application site pain 218 reports
Erythema 213 reports
See full Mechlorethamine Topical drug information
Keep checking

Other Drugs & Squalamine

Browse every other medication we’ve checked against Squalamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Squalamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Squalamine list.

See the full Squalamine interactions page
See every supplement checked against Mechlorethamine Hydrochloride, ranked by severity
Evidence & sources

Squalamine References

The 1 references that drive our Squalamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bhargava P, Marshall JL, Dahut W, et al. A phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin Cancer Res. 2001;7(12):3912-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Squalamine and Mechlorethamine Hydrochloride Together: Common Questions

Is it safe to take Squalamine with Mechlorethamine Hydrochloride?
We do not list a known interaction between Squalamine and Mechlorethamine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Mechlorethamine Hydrochloride interact with any supplements?
Yes. Mechlorethamine Hydrochloride has documented interactions with 10 supplements in our database — Squalamine is not one of them. The Mechlorethamine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Squalamine monograph Uses, safety profile, and every drug interaction in one place Mechlorethamine Topical drug information The full plain-English guide to this medication Mechlorethamine Hydrochloride supplement interactions Every supplement checked against Mechlorethamine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mechlorethamine Hydrochloride and Squalamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.