Medication interaction hub

What Supplements Interact with Mechlorethamine Hydrochloride?

Mechlorethamine Hydrochloride brand name: Valchlor. Every interaction below applies to the brands too.

10 Interactions 9 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 16, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Mechlorethamine Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Mechlorethamine Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Mechlorethamine (Valchlor) is a chemotherapy gel applied to the skin for a form of lymphoma, and the 10 supplements on this page split into two groups. Seven are antioxidants, everyday products like vitamin C and turmeric, which in theory could blunt how well an alkylating chemotherapy drug works. The other three go on skin too; DMSO in particular can pull topical drugs deeper than intended. Nothing here rates major, so for most people this is a watch-and-tell list, not a reason to stop treatment.

The evidence here is theoretical or early, so tell your oncology team or pharmacist which antioxidants you take and let them decide whether to pause one. Keep DMSO and similar products off the skin where you apply the gel. Nine of the ten interactions rate moderate, one minor, and knowing which combinations deserve watching is what the page below is for.

— , Clinical Pharmacist · July 18, 2026

Moderate 9 Minor 1 No known interaction 1,442

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Mechlorethamine Hydrochloride: Top Interactions at a Glance

The most significant Mechlorethamine Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 10 highest-ranked of 10 interacting ingredients — plus 1,442 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Mechlorethamine Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Acerola + Mechlorethamine Hydrochloridei

Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Alpha-lipoic Acid + Mechlorethamine Hydrochloridei

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Read the full interaction Moderate Likelihood Possible Coenzyme Q10 + Mechlorethamine Hydrochloridei

Coenzyme Q10 has antioxidant effects.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Mechlorethamine Hydrochloridei

Topical DMSO might increase the effects and adverse effects of topical drugs.

Read the full interaction Moderate Likelihood Possible Rose Hip + Mechlorethamine Hydrochloridei

Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative damage caused by cert...

Read the full interaction Moderate Likelihood Possible Turmeric + Mechlorethamine Hydrochloridei

Turmeric has antioxidant effects.

Read the full interaction
The complete list

Every Supplement Checked Against Mechlorethamine Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 10 with a Mechlorethamine Hydrochloride interaction on file and 1,442 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Mechlorethamine Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Acerola with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Mechlorethamine Hydrochloride answer

Can you take Alpha-lipoic Acid with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Full Alpha-lipoic Acid + Mechlorethamine Hydrochloride answer

Can you take Coenzyme Q10 with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Mechlorethamine Hydrochloride answer

Can you take Dimethylsulfoxide (dmso) with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Mechlorethamine Hydrochloride answer

Can you take Rose Hip with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative d...

Full Rose Hip + Mechlorethamine Hydrochloride answer

Can you take Turmeric with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Mechlorethamine Hydrochloride answer

Can you take Turpentine Oil with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Mechlorethamine Hydrochloride answer

Can you take Vitamin C with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Mechlorethamine Hydrochloride answer

Can you take Vitamin E with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Mechlorethamine Hydrochloride answer

Can you take Alchemilla with Mechlorethamine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Mechlorethamine Hydrochloride answer

Can you take Acerola with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of acerola might reduce the effectiveness of alkylating agents.

Full Acerola + Mechlorethamine Hydrochloride answer

Can you take Alpha-lipoic Acid with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.

Full Alpha-lipoic Acid + Mechlorethamine Hydrochloride answer

Can you take Coenzyme Q10 with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coenzyme Q10 has antioxidant effects.

Full Coenzyme Q10 + Mechlorethamine Hydrochloride answer

Can you take Dimethylsulfoxide (dmso) with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Mechlorethamine Hydrochloride answer

Can you take Rose Hip with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the antioxidant effects of rose hip might reduce the effectiveness of alkylating agents but might also reduce the oxidative d...

Full Rose Hip + Mechlorethamine Hydrochloride answer

Can you take Turmeric with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric has antioxidant effects.

Full Turmeric + Mechlorethamine Hydrochloride answer

Can you take Turpentine Oil with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Mechlorethamine Hydrochloride answer

Can you take Vitamin C with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.

Full Vitamin C + Mechlorethamine Hydrochloride answer

Can you take Vitamin E with Mechlorethamine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.

Full Vitamin E + Mechlorethamine Hydrochloride answer

Can you take Alchemilla with Mechlorethamine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Mechlorethamine Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Mechlorethamine Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Mechlorethamine Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Mechlorethamine Hydrochloride sits in 2 interaction categories. Open any one to see what the group means:

Alkylating Agents 7 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

7 of the supplement ingredients on this page reach Mechlorethamine Hydrochloride through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Mechlorethamine Hydrochloride through this category.

About Mechlorethamine Hydrochloride

Mechlorethamine gel is an alkylating agent chemotherapy used to treat early-stage cutaneous T-cell lymphoma skin cancer.

Generic name: Mechlorethamine Hydrochloride  ·  Brand name: Valchlor.

See the full Mechlorethamine Topical drug information

Related: does Mechlorethamine Hydrochloride deplete any nutrients?

Mechlorethamine Hydrochloride has 1 reported nutrient association in the research literature — see the Mechlorethamine Hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Mechlorethamine Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Mechlorethamine Hydrochloride.

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Pharmacist Counseling Corner

Mechlorethamine Hydrochloride & Supplements: Common Questions

What supplements interact with Mechlorethamine Hydrochloride?
Our database currently documents 10 ingredients with a known Mechlorethamine Hydrochloride interaction (0 major, 9 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 10. The highest-ranked right now: Acerola, Alpha-lipoic Acid, Coenzyme Q10.
Which Mechlorethamine Hydrochloride supplement interactions are the most serious?
None of the Mechlorethamine Hydrochloride supplement interactions on file are currently rated major. The most significant are the 9 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Mechlorethamine Hydrochloride?
Plenty of supplements coexist fine with Mechlorethamine Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Valchlor have the same supplement interactions as Mechlorethamine Hydrochloride?
Yes — Valchlor all contain Mechlorethamine Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Mechlorethamine Hydrochloride deplete any vitamins or nutrients?
It might — Mechlorethamine Hydrochloride has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Mechlorethamine Hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Mechlorethamine Hydrochloride and my other medications?
This page covers Mechlorethamine Hydrochloride against supplements and herbal ingredients. Checking Mechlorethamine Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Mechlorethamine Topical drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 16, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.