Drug & supplement interaction

Iron + Mechlorethamine Hydrochloride

Mechlorethamine Hydrochloride brand name: Valchlor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Iron and Mechlorethamine Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Iron and Mechlorethamine Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mechlorethamine Hydrochloride and Iron in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Iron safety at a glance

Iron overall Use caution Generally safe at recommended doses, but excess iron can be toxic and supplements should be used when there is a real need.
Pregnancy Likely Safe When used orally and appropriately. Iron is safe during pregnancy and breast-feeding in patients with adequate iron stores when used in doses below the tolerabl... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately. Iron is safe during pregnancy and breast-feeding in patients with adequate iron stores when used in doses below the tolerabl... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mechlorethamine Hydrochloride and Iron? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mechlorethamine Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mechlorethamine Hydrochloride is filed under 2 classifications — alkylating agents, topical drugs. Iron has documented interactions with 13 drug classes — the most serious being bictegravir/emtricitabine/tenofovir alafenamide (biktarvy) (moderate), bisphosphonates (moderate) and denosumab (prolia, others) (moderate) — and none of Mechlorethamine Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Iron Does Interact With Other Medications

Iron has 79 moderate, 1 minor known drug interactions in our database — Mechlorethamine Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 79 Minor 1 No known interaction 2,750 (incl. Mechlorethamine Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Iron

Covers the 2,830 medications we’ve checked against Iron. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Iron and Mechlorethamine Hydrochloride May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Iron

    “Although there is some clinical research associating iron supplementation with an increased rate of malaria infection, the strongest evidence to date does not support this association, at least for areas where antimalarial treatment is available. In an analysis of 14 trials, iron supplementation was not associated with an increased risk of malaria.”

    Iron · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 56796. van den, Hombergh J., Dalderop, E., and Smit, Y. Does iron therapy benefit children with severe malaria-associated anaemia? A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani Division, Tanzania. J.Trop.Pediatr. PubMed
    2. 95432. Esan MO, Boele van Hensbroek M, Nkhoma E, et al. Iron supplementation in HIV infected Malawian children with anemia: a double-blind, randomized, controlled trial. Clin Inf Dis 2013;57(11):1626-34.doi:10.1093/cid/cit528. PubMed
    3. 95433. Zlotkin S, Newton S, Aimone AM, et al. Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial. JAMA 2013;310(9):938-47. PubMed
    4. 96623. Neuberger A, Okebe J, Yahav D, Paul M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst Rev. 2016;2:CD006589. PubMed
    5. 110186. Shah AA, Donovan K, Seeley C, et al. Risk of infection associated with administration of intravenous iron: A systematic review and meta-analysis. JAMA Netw Open 2021;4(11):e2133935. PubMed
    6. 115892. Meyers M, Salmon M, Libert I, Klášterský J. A meta-analysis on the risk of infection associated with intravenous iron therapy in cancer-associated anaemia: a double-edged sword?. Curr Opin Oncol 2024;36(4):223-232. PubMed

    Mechlorethamine Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Mechlorethamine Hydrochloride. Read the label on DailyMed ›

  • Itching / A skin rash reported in 24.3% of FDA reports for Mechlorethamine Hydrochloride Additional detail

    Iron

    “Intravenously, sodium ferric gluconate complex (SFGC) caused drug intolerance reactions in 0.4% of hemodialysis patients including 2 patients with pruritus and one patient each with anaphylactoid reaction, hypotension, chills, back pain, dyspnea/chest pain, facial flushing, rash and cutaneous symptoms of porphyria.”

    Iron · Natural Medicines adverse-effect record, reported in back pain.

    1 source cited
    1. 56527. Michael, B., Coyne, D. W., Fishbane, S., Folkert, V., Lynn, R., Nissenson, A. R., Agarwal, R., Eschbach, J. W., Fadem, S. Z., Trout, J. R., Strobos, J., and Warnock, D. G. Sodium ferric gluconate complex in hemodialysis patients: adverse reactions compar

    Mechlorethamine Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Mechlorethamine Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Iron but not commonly for Mechlorethamine Hydrochloride: kidney problems, a severe allergic reaction, a heart attack and sweating.

Effects for Mechlorethamine Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Iron come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 2,244 voluntary FDA FAERS reports for Mechlorethamine Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Iron in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. Iron is safe during pregnancy and breast-feeding in patients with adequate iron stores when used in doses below the tolerable upper intake level (UL) of 45 mg daily of elemental iron.

Pregnancy And Lactation Likely Unsafe

When used orally in high doses. Tell patients who are not iron deficient to avoid exceeding the tolerable upper intake level (UL) of 45 mg daily of elemental iron. Higher doses frequently cause gastrointestinal side effects such as nausea and vomiting and might increase the risk of preterm labor. High hemoglobin concentrations at the time of delivery are associated with adverse pregnancy outcomes.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Iron or Mechlorethamine Hydrochloride

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Iron or Mechlorethamine Hydrochloride, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mechlorethamine Hydrochloride

This page covers Iron only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mechlorethamine Hydrochloride page lists 10 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate), Dimethylsulfoxide (dmso) (moderate) and Rose Hip (moderate).

By severity: 9 moderate · 1 minor.

From our pharmacist’s overview on the Mechlorethamine Hydrochloride page

“Mechlorethamine (Valchlor) is a chemotherapy gel applied to the skin for a form of lymphoma, and the 10 supplements on this page split into two groups. Seven are antioxidants, everyday products like vitamin C and turmeric, which in theory could blunt how well an alkylating chemotherapy drug works.”

Reviewed by 2 · Jul 18, 2026

Open the Mechlorethamine Hydrochloride interaction page

One more smart check

Taking Iron as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16,325 real supplement products containing Iron, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Iron. Even though Iron itself has no known interaction with Mechlorethamine Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Iron and Mechlorethamine Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Iron
Top 1%

#14 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mechlorethamine Hydrochloride
Steady interest

#1,817 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Iron reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Iron and Mechlorethamine Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Iron

What is Iron?

  • Iron-deficiency anemia
  • Low iron stores during pregnancy
  • Fatigue from iron deficiency
  • Heavy menstrual blood loss
  • Restless legs syndrome (with low iron)

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency anemia, ideally after a blood test confirms you are low. Because too much iron can be harmful, take it only when needed and under the guidance of a pharmacist or doctor.

Mineral (essential trace element) · Tablets, capsules, liquid/drops, gummies, chewables, and intravenous (IV) preparations

An interaction check asks whether these two react with each other — it does not ask whether Iron is a good idea for someone in your situation. Here is what our Iron record says about it on its own.

Iron: dosing

Treatment doses for anemia are usually higher than amounts found in a daily multivitamin.Follow the dose on your product label or the dose your healthcare provider gives you.

From our Iron monograph — the full record covers uses, side effects and every documented interaction.

Read the full Iron monograph & all interactions
Medication

About Mechlorethamine Topical

What Is Mechlorethamine Topical Used For?

Brand name: Valchlor

Valchlor (mechlorethamine gel applied to the skin) is approved to treat Stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma — a slow-growing cancer that primarily affects the skin. It is used in patients who have already received at least one prior skin-directed treatment.

Most-Reported Side Effects for Mechlorethamine Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (2,244 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Pruritus 322 reports
Application site pruritus 224 reports
Application site erythema 220 reports
Application site pain 218 reports
Erythema 213 reports
See full Mechlorethamine Topical drug information
Keep checking

Other Drugs & Iron

Browse every other medication we’ve checked against Iron — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
79Moderate
1Minor
2,749No known interaction
79 Moderate 1 Minor 2,749 No interaction
Moderate

79 interactions

Showing 60 of 79 moderate interactions — see all 79 on the Iron page.

Minor

1 interaction

No interaction 2,749 drugs checked — show the list

We also checked Iron against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,749 medications checked with no known interaction — see the full Iron list.

See the full Iron interactions page
See every supplement checked against Mechlorethamine Hydrochloride, ranked by severity
Evidence & sources

Iron References

The 72 references that drive our Iron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
  3. Ullen H, Augustsson K, Gustavsson C, Steineck G. Supplementary iron intake and risk of cancer: reversed causality? Cancer Lett 1997;114:215-6.
  4. Reunanen A, Takkunen H, Knekt P, et al. Body iron stores, dietary iron intake and coronary heart disease mortality. J Intern Med 1995;238:223-30. PubMed
  5. Lund EK, Wharf SG, Fairweather-Tait SJ, Johnson IT. Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am J Clin Nutr 1999;69:250-5.
  6. Rehman A, Collis CS, Yang M, et al. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem Biophys Res Comm 1998;246:293-8. PubMed
  7. Klipstein-Grobusch K, Grobbee DE, den Breeijen JH, et al. Dietary iron and risk of myocardial infarction in the Rotterdam Study. Am J Epidemiol 1999;149:421-8. PubMed
  8. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  9. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Campbell N, Paddock V, Sundaram R. Alteration of methyldopa absorption, metabolism, and blood pressure control by ferrous sulfate and ferrous gluconate. Clin Pharmacol Ther 1988;43:381-6..
  12. Schumann K, Borch-Iohnsen B, Hentze MW, Marx JJ. Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board (commentary). Am J Clin Nutr 2002;76:499-500. PubMed
  13. Tuomainen TP, Punnonen K, Nyyssonen K, Salonen JT. Association between body iron stores and the risk of acute myocardial infarction in men. Circulation 1998;97:1461-6.. PubMed
  14. Salonen JT, Nyyssonen K, Korpela H, et al. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 1992;86:803-11.. PubMed
  15. Campbell NRC, Hasinoff B. Ferrous sulfate reduces levodopa bioavailability: Chelation as a possible mechanism. Clin Pharmacol Ther 1989;45:220-5.. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Iron and Mechlorethamine Hydrochloride Together: Common Questions

Is it safe to take Iron with Mechlorethamine Hydrochloride?
We do not list a known interaction between Iron and Mechlorethamine Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Iron and Mechlorethamine Hydrochloride have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Iron and Mechlorethamine Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Mechlorethamine Hydrochloride is filed under 2 classifications, and Iron has documented interactions with 13 drug classes — none of Mechlorethamine Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Iron interact with any other medications?
Yes. Iron has 80 documented drug interactions in our database — Mechlorethamine Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mechlorethamine Hydrochloride interact with any supplements?
Yes. Mechlorethamine Hydrochloride has documented interactions with 10 supplements in our database — Iron is not one of them. The Mechlorethamine Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Iron monograph Uses, safety profile, and every drug interaction in one place Mechlorethamine Topical drug information The full plain-English guide to this medication Mechlorethamine Hydrochloride supplement interactions Every supplement checked against Mechlorethamine Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 72 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mechlorethamine Hydrochloride and Iron?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.