Drug & supplement interaction

Stone Root + Alteplase, tPA

Alteplase, tPA brand names: Activase, Actilyse.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Stone Root and Alteplase, tPA in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Stone Root and Alteplase, tPA

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alteplase, tPA and Stone Root in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Stone Root at all — not against Alteplase, tPA, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Stone Root safety at a glance

Stone Root overall Use caution Little safety data exists, so use with care and under professional guidance.
Pregnancy Avoid Not enough safety information is available, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alteplase, tPA and Stone Root? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Stone Root Itself Has Been Linked To

This is not an interaction — nothing below involves Alteplase, tPA. It is the side-effect record for Stone Root on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Stone Root, this list is the first place to look.

  • Dizziness / Nausea Additional detail

    “Orally, large amounts of stone root can cause intestinal tract irritation and colic-like pain dizziness, and nausea (18).”

    Stone Root · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Stone Root — expand a row for the licensed statement it rests on. We haven’t matched Alteplase, tPA to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Alteplase, tPA.

Everything else you take

See Every Supplement That Interacts With Alteplase, tPA

This page covers Stone Root only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alteplase, tPA page lists 219 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).

By severity: 3 major · 191 moderate · 25 minor.

From our pharmacist’s overview on the Alteplase, tPA page

“Nobody plans to receive alteplase (Activase, tPA). It arrives by IV in an emergency to dissolve the clot behind a stroke or heart attack, so the supplements already in your system at that moment matter, and this list deserves real weight.”

Reviewed by 2 · Jul 18, 2026

Open the Alteplase, tPA interaction page

One more smart check

Taking Stone Root as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Stone Root, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Stone Root. Even though Stone Root itself has no known interaction with Alteplase, tPA, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Stone Root and Alteplase, tPA Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Stone Root
Top half

#716 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alteplase, tPA
Steady interest

#1,935 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Stone Root reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Stone Root and Alteplase, tPA records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Stone Root

What is Stone Root?

Stone Root
  • Hemorrhoids
  • Urinary and bladder discomfort
  • Digestive upset
  • Sore throat and hoarseness
  • Kidney stones (traditional)

Stone root is a North American herb traditionally used for hemorrhoids, urinary complaints, and digestive issues. There is very little modern scientific evidence to confirm it works for any of these uses, so it should be viewed as a traditional remedy rather than a proven treatment. Talk with your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.

Collinsonia canadensis · Lamiaceae · Root and rhizome · Tincture, capsules, dried root for tea, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Stone Root is a good idea for someone in your situation. Here is what our Stone Root record says about it on its own.

Stone Root: dosing

There is no established standard dose for stone root. Traditional preparations include teas made from the dried root and alcohol-based tinctures, but reliable dosing guidelines from clinical studies do not exist.The safest approach is to follow the directions on the product label and not exceed them.

From our Stone Root monograph — the full record covers uses, side effects and every documented interaction.

Read the full Stone Root monograph & all interactions
Keep checking

Other Drugs & Stone Root

Browse every other medication we’ve checked against Stone Root — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Stone Root against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Stone Root list.

See the full Stone Root interactions page
See every supplement checked against Alteplase, tPA, ranked by severity
Evidence & sources

Stone Root References

The 1 references that drive our Stone Root monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Stone Root and Alteplase, tPA Together: Common Questions

Is it safe to take Stone Root with Alteplase, tPA?
We do not list a known interaction between Stone Root and Alteplase, tPA. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Alteplase, tPA interact with any supplements?
Yes. Alteplase, tPA has documented interactions with 219 supplements in our database — Stone Root is not one of them. The Alteplase, tPA interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Stone Root monograph Uses, safety profile, and every drug interaction in one place Alteplase, tPA supplement interactions Every supplement checked against Alteplase, tPA, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alteplase, tPA and Stone Root?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.