Medication interaction hub

What Supplements Interact with Alteplase, tPA?

Alteplase, tPA brand names: Activase, Actilyse. Every interaction below applies to the brands too.

219 Interactions 3 Major 191 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Alteplase, tPA? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Alteplase, tPA against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Nobody plans to receive alteplase (Activase, tPA). It arrives by IV in an emergency to dissolve the clot behind a stroke or heart attack, so the supplements already in your system at that moment matter, and this list deserves real weight. Of 219 ingredients on file, 202 raise bleeding risk by thinning blood or dulling platelets, stacking onto a drug built to break clots apart. Three are rated major, danshen and piracetam among them, and those are the entries to understand first.

There is no spacing doses around an emergency infusion, so the useful step happens beforehand. If you or someone you care for takes herbal blood thinners such as danshen, be sure the hospital team hears the full list. Of the rest, 191 are moderate and 25 minor, nearly all pointing toward extra bleeding. Activated charcoal, the third major entry, is different, lowering drug levels rather than adding bleeding risk.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 191 Minor 25 No known interaction 1,233

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Alteplase, tPA: Top Interactions at a Glance

The Alteplase, tPA supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 219 interacting ingredients — plus 1,233 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Alteplase, tPA Combinations Today

The Alteplase, tPA + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Fish Oil + Alteplase, tPAi

Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Possible Black Psyllium + Alteplase, tPAi

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Moderate Likelihood Unlikely Green Tea + Alteplase, tPAi

Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Dong Quai + Alteplase, tPAi

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.

Read the full interaction Moderate Likelihood Possible Thyme + Alteplase, tPAi

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Guggul + Alteplase, tPAi

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Alteplase, tPA

All 1,452 ingredients in our database, ranked by severity — 219 with a Alteplase, tPA interaction on file and 1,233 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Alteplase, tPA?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Fish Oil with Alteplase, tPA?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fish oil may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Fish Oil + Alteplase, tPA answer

Can you take Black Psyllium with Alteplase, tPA?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Alteplase, tPA answer

Can you take Green Tea with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Green Tea + Alteplase, tPA answer

Can you take Dong Quai with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflict...

Full Dong Quai + Alteplase, tPA answer

Can you take Thyme with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.

Full Thyme + Alteplase, tPA answer

Can you take Bridelia with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, orally administered extracts of Bridelia ferruginea stem bark inhibit ADP/adrenaline-induced thrombosis by approximately 62%.The...

Full Bridelia + Alteplase, tPA answer

Can you take Coffee Charcoal with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Alteplase, tPA answer

Can you take European Mandrake with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Alteplase, tPA answer

Can you take Glucomannan with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Alteplase, tPA answer

Can you take Willow Bark with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, willow bark might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Willow Bark + Alteplase, tPA answer

Can you take Aconite with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining aconite with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.

Full Aconite + Alteplase, tPA answer

Can you take Allspice with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.

Full Allspice + Alteplase, tPA answer

Can you take Aloe with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Aloe + Alteplase, tPA answer

Can you take Alpha-lipoic Acid with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplate...

Full Alpha-lipoic Acid + Alteplase, tPA answer

Can you take Andrographis with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Andrographis + Alteplase, tPA answer

Can you take Asafoetida with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asafoetida might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Asafoetida + Alteplase, tPA answer

Can you take Atractylodes with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, atractylodes might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.

Full Atractylodes + Alteplase, tPA answer

Can you take Babassu with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that babassu has antithrombotic effects.

Full Babassu + Alteplase, tPA answer

Can you take Baikal Skullcap with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.

Full Baikal Skullcap + Alteplase, tPA answer

Can you take Basil with Alteplase, tPA?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Basil + Alteplase, tPA answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Alteplase, tPA is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Alteplase, tPA, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Alteplase, tPA sits in 3 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Alteplase, tPA through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Alteplase, tPA through this category.

Thrombolytic Drugs 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Alteplase, tPA through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Alteplase, tPA

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Alteplase, tPA.

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Pharmacist Counseling Corner

Alteplase, tPA & Supplements: Common Questions

What supplements interact with Alteplase, tPA?
Our database currently documents 219 ingredients with a known Alteplase, tPA interaction (3 major, 191 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 219. The highest-ranked right now: Activated Charcoal, Danshen, Piracetam.
Which Alteplase, tPA supplement interactions are the most serious?
The 3 major-rated combinations — led by Activated Charcoal, Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Alteplase, tPA?
Plenty of supplements coexist fine with Alteplase, tPA; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Activase have the same supplement interactions as Alteplase, tPA?
Yes — Activase, Actilyse all contain Alteplase, tPA, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Alteplase, tPA and my other medications?
This page covers Alteplase, tPA against supplements and herbal ingredients. Checking Alteplase, tPA against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.