Potato + Alteplase, tPA
Alteplase, tPA brand names: Activase, Actilyse.
Potato has a moderate interaction with Alteplase, tPA. Theoretically, concomitant use of potato may enhance the effects of thrombolytic drugs.
Read the full interaction reportPotato and Alteplase, tPA
Here is the interaction we found between these two, with the evidence behind it.
THROMBOLYTIC DRUGS
Why this applies to Alteplase, tPA
Alteplase, tPA falls under THROMBOLYTIC DRUGS — the group Potato interacts with.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist: Alteplase (Activase) is a clot-busting drug given in the hospital for things like strokes, heart attacks, or large blood clots. It works fast and hard to dissolve clots, and its main risk is bleeding. The concern with potato is purely theoretical. A compound found in potato tubers may block one of the body's natural brakes on clot breakdown, which could, in theory, make a thrombolytic like alteplase work even more strongly and raise the chance of bleeding.
That said, this idea comes only from lab studies, not real people, so I wouldn't lose sleep over it. Eating normal potatoes is not the same as a concentrated extract. Since alteplase is given under close medical watch anyway, just let your care team know about any supplements you use.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Potato Also Interacts With Other Medications
Potato has 6 moderate known drug interactions in our database — the Alteplase, tPA one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Potato
We haven’t checked that one against Potato yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Potato. Pick one to open its full report.
See Every Supplement That Interacts With Alteplase, tPA
This page covers Potato only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alteplase, tPA page lists 219 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), Aconite (moderate) and Allspice (moderate).
By severity: 3 major · 191 moderate · 25 minor.
From our pharmacist’s overview on the Alteplase, tPA page
“Nobody plans to receive alteplase (Activase, tPA). It arrives by IV in an emergency to dissolve the clot behind a stroke or heart attack, so the supplements already in your system at that moment matter, and this list deserves real weight.”
Reviewed by 2 · Jul 18, 2026
Taking Potato as Part of a Dietary Supplement Product? Check It for Interactions
We hold 140 real supplement products containing Potato, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Potato. Your product may carry other ingredients that interact with Alteplase, tPA too, on top of Potato — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Potato and Alteplase, tPA Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#566 of 1,452 supplements looked up here in the last 7 days
#1,727 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Potato
What is Potato?
- Digestive complaints and heartburn
- Minor skin irritation or burns (topical folk use)
- Joint or muscle aches (traditional poultice)
- Source of carbohydrates and potassium in the diet
- Eye puffiness (cosmetic folk use)
Potato is a common food, and as a supplement it is mostly used in folk remedies such as raw potato juice for stomach upset or as a topical poultice. Solid scientific evidence for these uses is very limited. The edible tuber is safe as food, but green, sprouted, or raw potato in large amounts can contain natural toxins, so use caution and talk to your pharmacist before using potato as a remedy.
Other Drugs & Potato
Browse every other medication we’ve checked against Potato — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
6 interactions
No interaction 2,823 drugs checked — show the list
We also checked Potato against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Semaglutide ›
- Sumatriptan ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Fluoxetine ›
- Lamotrigine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,823 medications checked with no known interaction — see the full Potato list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Potato and Alteplase, tPA Together: Common Questions
Can you take Potato with Alteplase, tPA?
How serious is the Potato and Alteplase, tPA interaction?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.