Drug & supplement interaction

Suma + Sorafenib

Sorafenib brand name: Nexavar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Suma and Sorafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sorafenib states a food rule worth keeping to.

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Interaction report

Suma and Sorafenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sorafenib and Suma in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Suma at all — not against Sorafenib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Suma safety at a glance

Suma overall Use caution Generally used in foods and supplements, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sorafenib and Suma? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Suma Itself Has Been Linked To

This is not an interaction — nothing below involves Sorafenib. It is the side-effect record for Suma on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Suma, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    “Orally, suma seems to be well tolerated (12). No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted. When inhaled, powdered suma root can cause occupational asthma.”

    Suma · Natural Medicines adverse-effect record, reported in asthma.

    3 sources cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
    2. 515. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
    3. 76647. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

    “When inhaled, suma root powder has caused allergic asthma symptoms in a single patient.”

    Suma · Natural Medicines adverse-effect record, reported in asthma.

    1 source cited
    1. 76647. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Suma — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Sorafenib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Sorafenib column appears here.

How to take them

Some Sorafenib Products Have a Food Rule — Suma Should Not Break It

At least one FDA label for a product containing Sorafenib says to take it on an empty stomach. Most supplements — Suma included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Sorafenib on its own and move Suma to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sorafenib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended dosage is 400 mg orally twice daily without food.

From the Dosage and Administration section of the FDA label we read for Sorafenib — where that label names a specific product, the instruction is that product's. See the Sorafenib drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sorafenib

This page covers Suma only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sorafenib page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 241 moderate · 39 minor.

From our pharmacist’s overview on the Sorafenib page

“If you're on sorafenib (Nexavar) for cancer, be genuinely careful here, and learn the five major-rated entries first. Most of the 285 ingredients listed either have blood-thinning effects that stack onto sorafenib's bleeding risk (more than 200 do) or affect CYP3A4, the liver enzyme that clears the drug, pushing its level too high or t…”

Reviewed by 2 · Jul 18, 2026

Open the Sorafenib interaction page

One more smart check

Taking Suma as Part of a Dietary Supplement Product? Check It for Interactions

We hold 438 real supplement products containing Suma, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Suma. Even though Suma itself has no known interaction with Sorafenib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Suma and Sorafenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Suma
Top half

#415 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sorafenib
Steady interest

#2,213 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Suma reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Suma and Sorafenib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Suma

What is Suma?

  • General energy and vitality
  • Adaptogen for stress
  • Sexual health and libido
  • Athletic performance
  • Immune support
  • Hormonal balance

Suma is a South American root often marketed as a 'Brazilian ginseng' and used as an adaptogen for energy, stamina, and stress. Human evidence is very limited, and most claims come from traditional use and lab or animal studies. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a hormone-sensitive condition.

Pfaffia paniculata · Amaranthaceae · Root · Capsules, powder, tablets, tincture, tea

An interaction check asks whether these two react with each other — it does not ask whether Suma is a good idea for someone in your situation. Here is what our Suma record says about it on its own.

Suma: dosing

There is no well-established standardized dose for Suma. Studies are too limited to recommend a specific amount, and product strengths vary widely.If you choose to use it, follow the dosing directions on the product label and do not exceed them. A pharmacist can help you review a product and decide whether it is appropriate for you.Start low, watch for any reactions, and stop if you notice side effects.

From our Suma monograph — the full record covers uses, side effects and every documented interaction.

Read the full Suma monograph & all interactions
Medication

About Sorafenib

What Is Sorafenib Used For?

Brand name: Nexavar

Sorafenib tablets are approved to treat three types of cancer. The first is unresectable hepatocellular carcinoma (HCC) — liver cancer that cannot be removed with surgery. The second is advanced renal cell carcinoma (RCC) — kidney cancer that has spread or progressed. Both the brand Nexavar and generic sorafenib tablets are approved for these two uses.

The third use is for locally recurrent or metastatic, progressive differentiated thyroid carcinoma (DTC) — thyroid cancer that has spread or worsened and no longer responds to radioactive iodine treatment. Nexavar and sorafenib tablets are both approved for this use as well.

See full Sorafenib drug information
Keep checking

Other Drugs & Suma

Browse every other medication we’ve checked against Suma — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Suma against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Suma list.

See the full Suma interactions page
See every supplement checked against Sorafenib, ranked by severity
Evidence & sources

Suma References

The 3 references that drive our Suma monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
  3. Subiza, J., Subiza, J. L., Escribano, P. M., Hinojosa, M., Garcia, R., Jerez, M., and Subiza, E. Occupational asthma caused by Brazil ginseng dust. J Allergy Clin Immunol 1991;88(5):731-736. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Suma and Sorafenib Together: Common Questions

Is it safe to take Suma with Sorafenib?
We do not list a known interaction between Suma and Sorafenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Suma and Sorafenib at the same time of day?
At least one FDA label for a product containing Sorafenib says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Sorafenib on its own and move Suma to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Sorafenib interact with any supplements?
Yes. Sorafenib has documented interactions with 285 supplements in our database — Suma is not one of them. The Sorafenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Suma monograph Uses, safety profile, and every drug interaction in one place Sorafenib drug information The full plain-English guide to this medication Sorafenib supplement interactions Every supplement checked against Sorafenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sorafenib and Suma?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.