Drug & supplement interaction

Sweet Sumac + Solifenacin succinate

Solifenacin succinate brand name: Vesicare.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Sweet Sumac and Solifenacin succinate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Sweet Sumac and Solifenacin succinate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Solifenacin succinate and Sweet Sumac in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Sweet Sumac at all — not against Solifenacin succinate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Sweet Sumac safety at a glance

Sweet Sumac overall Use caution Limited safety data exist, and it is related to plants that can cause skin reactions.
Pregnancy Avoid There is not enough safety information, so avoid use during pregnancy.
Breastfeeding Avoid Safety is unknown while breastfeeding, so it is best to avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Solifenacin succinate and Sweet Sumac? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Sweet Sumac and Solifenacin succinate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Sweet Sumac

    “Orally, infections of the urogenital tract have been reported in women with overactive bladder who were taking a combination product (Granu Fink femina, Omega Pharma) containing sweet sumac bark extract, pumpkin seed oil, and hops cone extract. It is unclear if these adverse effects were due to sweet sumac, other ingredients, or the combination.”

    Sweet Sumac · Natural Medicines adverse-effect record, reported in overactive bladder.

    1 source cited
    1. 103253. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

    Solifenacin succinate

    Listed in the ADVERSE REACTIONS section of the FDA label for Solifenacin succinate. Read the label on DailyMed ›

Effects for Solifenacin succinate come from the ADVERSE REACTIONS section of its FDA label; effects for Sweet Sumac come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 25,864 voluntary FDA FAERS reports for Solifenacin succinate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Solifenacin succinate Is Prescribed For, and What Sweet Sumac Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Solifenacin succinate is a prescription medicine with approved uses on its FDA label. Sweet Sumac is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Solifenacin succinate is prescribed for: Solifenacin tablets (including the brands solifenacin succinate and VESIcare) are approved for adults with overactive bladder — specifically the symptoms of sudden urges to urinate, leaking urine due to those urges (urge urinary incontinence), and needing to urinate very frequently. VESIcare LS oral suspension is approved for a different use: treating neurogenic detrusor overactivity (NDO) — a bladder control problem caused by nerve damage or a nervous system condition — in children aged 2 years and older. This liquid formulation is dosed by the child's weight.

Sweet Sumac has been studied for:

  • Overactive bladder studied, not established Sweet Sumac has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Sweet Sumac for overactive bladder

    Preliminary clinical research in women with overactive bladder shows that taking a specific combination product (Granu Fink femina, Omega Pharma) containing sweet sumac bark extract 56 mg, pumpkin seed oil 227 mg, and hops cone extract 18 mg three times daily for 12 weeks decreases the frequency of urination and leakage and improves quality of life when compared to baseline.

    1 source cited
    1. 103253. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Solifenacin succinate on your own; if you are taking Sweet Sumac for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Solifenacin succinate

This page covers Sweet Sumac only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Solifenacin succinate page lists 169 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 10 major · 117 moderate · 42 minor.

From our pharmacist’s overview on the Solifenacin succinate page

“People taking solifenacin (Vesicare) for overactive bladder are often older adults who also reach for sleep herbs, memory blends, or fiber supplements, and that combination warrants real caution, since 10 of the 169 interacting ingredients here are rated major. Most of the list, 121 ingredients, affects the liver enzyme CYP3A4 that cle…”

Reviewed by 2 · Jul 18, 2026

Open the Solifenacin succinate interaction page

How much people look this up

Where Sweet Sumac and Solifenacin succinate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Sweet Sumac
Steady interest

#1,022 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Solifenacin succinate
Steady interest

#1,688 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Sweet Sumac reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Sweet Sumac and Solifenacin succinate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Sweet Sumac

What is Sweet Sumac?

  • Urinary complaints
  • Diarrhea
  • Excessive urination or bedwetting
  • Sore throat and mouth rinse
  • Mild bleeding

Sweet Sumac (Rhus aromatica) is a North American shrub used in traditional and folk medicine, mostly for urinary and digestive complaints. There is very little modern human research to confirm that it works for any condition, so its benefits remain unproven. Because it belongs to the same plant family as poison ivy, talk with a pharmacist or doctor before using it.

Rhus aromatica · Anacardiaceae · Bark of the root, leaves, and berries · Dried bark, tea, tincture, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Sweet Sumac is a good idea for someone in your situation. Here is what our Sweet Sumac record says about it on its own.

Sweet Sumac: dosing

There is no established, standardized dose for Sweet Sumac. It has traditionally been taken as a tea, tincture, or liquid extract made from the root bark or leaves, but reliable dosing guidelines from clinical research are not available.If you choose to use a commercial product, follow the directions on the label and do not exceed the suggested amount.

From our Sweet Sumac monograph — the full record covers uses, side effects and every documented interaction.

Read the full Sweet Sumac monograph & all interactions
Medication

About Solifenacin

What Is Solifenacin Used For?

Brand name: Vesicare

Solifenacin tablets (including the brands solifenacin succinate and VESIcare) are approved for adults with overactive bladder — specifically the symptoms of sudden urges to urinate, leaking urine due to those urges (urge urinary incontinence), and needing to urinate very frequently.

VESIcare LS oral suspension is approved for a different use: treating neurogenic detrusor overactivity (NDO) — a bladder control problem caused by nerve damage or a nervous system condition — in children aged 2 years and older. This liquid formulation is dosed by the child's weight.

See full Solifenacin drug information
Keep checking

Other Drugs & Sweet Sumac

Browse every other medication we’ve checked against Sweet Sumac — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Sweet Sumac against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Sweet Sumac list.

See the full Sweet Sumac interactions page
See every supplement checked against Solifenacin succinate, ranked by severity
Evidence & sources

Sweet Sumac References

The 1 references that drive our Sweet Sumac monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gauruder-Burmester A, Heim S, Patz B, Seibt S. Cucurbita pepo-Rhus aromatica-Humulus lupulus combination reduces overactive bladder symptoms in women - a noninterventional study. Planta Med. 2019;85(13):1044-53. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Sweet Sumac and Solifenacin succinate Together: Common Questions

Is it safe to take Sweet Sumac with Solifenacin succinate?
We do not list a known interaction between Sweet Sumac and Solifenacin succinate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Sweet Sumac and Solifenacin succinate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Sweet Sumac and Solifenacin succinate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Sweet Sumac in each. That is a conversation for your prescriber, especially if Solifenacin succinate is being adjusted to a target.
Does Solifenacin succinate interact with any supplements?
Yes. Solifenacin succinate has documented interactions with 169 supplements in our database — Sweet Sumac is not one of them. The Solifenacin succinate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Sweet Sumac monograph Uses, safety profile, and every drug interaction in one place Solifenacin drug information The full plain-English guide to this medication Solifenacin succinate supplement interactions Every supplement checked against Solifenacin succinate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Solifenacin succinate and Sweet Sumac?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.