Medication interaction hub

What Supplements Interact with Solifenacin succinate?

Solifenacin succinate brand name: Vesicare. Every interaction below applies to the brands too.

169 Interactions 10 Major 117 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Solifenacin succinate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Solifenacin succinate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People taking solifenacin (Vesicare) for overactive bladder are often older adults who also reach for sleep herbs, memory blends, or fiber supplements, and that combination warrants real caution, since 10 of the 169 interacting ingredients here are rated major. Most of the list, 121 ingredients, affects the liver enzyme CYP3A4 that clears solifenacin from the body; grapefruit can push its levels up, while St. John's wort can drop them until bladder symptoms return. Another 30 herbs share solifenacin's drying anticholinergic action, stacking dry mouth, constipation, blurred vision, and confusion.

Solifenacin can also lengthen the heart's QT interval, the timing of each beat, and 13 ingredients may add to that rhythm risk, where several of the majors sit. Seventeen more, activated charcoal among them, can keep the pill from absorbing, so space those well apart from your dose. The 117 moderate and 42 minor entries are less pressing; start with the 10 majors and understand why each made the cut.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 117 Minor 42 No known interaction 1,283

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Solifenacin succinate: Top Interactions at a Glance

The Solifenacin succinate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 169 interacting ingredients — plus 1,283 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Solifenacin succinate Combinations Today

The Solifenacin succinate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Yohimbe + Solifenacin succinatei

Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Boswellia Serrata + Solifenacin succinatei

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Schisandra + Solifenacin succinatei

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Scopolia + Solifenacin succinatei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction Minor Likelihood Possible Hibiscus Sabdariffa + Solifenacin succinatei

Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Bael + Solifenacin succinatei

Bael and its constituents marmelosin and marmesinin inhibited cytochrome P450 3A4 (CYP3A4) activity in vitro.

Read the full interaction
The complete list

Every Supplement Checked Against Solifenacin succinate

All 1,452 ingredients in our database, ranked by severity — 169 with a Solifenacin succinate interaction on file and 1,283 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Solifenacin succinate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Yohimbe with Solifenacin succinate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.

Full Yohimbe + Solifenacin succinate answer

Can you take Boswellia Serrata with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Solifenacin succinate answer

Can you take Schisandra with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Schisandra + Solifenacin succinate answer

Can you take Scopolia with Solifenacin succinate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of...

Full Scopolia + Solifenacin succinate answer

Can you take Hibiscus Sabdariffa with Solifenacin succinate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Hibiscus sabdariffa extract might reduce the metabolism of CYP3A4 substrates.

Full Hibiscus Sabdariffa + Solifenacin succinate answer

Can you take Eucalyptus with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Solifenacin succinate answer

Can you take European Barberry with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Solifenacin succinate answer

Can you take Evodia with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Full Evodia + Solifenacin succinate answer

Can you take False Unicorn with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Solifenacin succinate answer

Can you take Fennel with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Solifenacin succinate answer

Can you take Feverfew with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Solifenacin succinate answer

Can you take Fo-ti with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Solifenacin succinate answer

Can you take Garlic with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Solifenacin succinate answer

Can you take German Chamomile with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Solifenacin succinate answer

Can you take Ginger with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Solifenacin succinate answer

Can you take Ginkgo with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Solifenacin succinate answer

Can you take Goji with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Solifenacin succinate answer

Can you take Goldenseal with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Solifenacin succinate answer

Can you take Goldthread with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Solifenacin succinate answer

Can you take Grape with Solifenacin succinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Solifenacin succinate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Solifenacin succinate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Solifenacin succinate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Solifenacin succinate sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Solifenacin succinate through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Solifenacin succinate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Solifenacin succinate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Solifenacin succinate through this category.

Urinary Acidifying Agents 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Solifenacin succinate through this category.

About Solifenacin succinate

Solifenacin is a bladder relaxant used to treat overactive bladder in adults and, as VESIcare LS oral suspension, neurogenic detrusor overactivity in children aged 2 and older.

Generic name: Solifenacin succinate  ·  Brand name: Vesicare.

See the full Solifenacin drug information
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Take a Supplement Product? Check the Whole Bottle Against Solifenacin succinate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Solifenacin succinate.

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Pharmacist Counseling Corner

Solifenacin succinate & Supplements: Common Questions

What supplements interact with Solifenacin succinate?
Our database currently documents 169 ingredients with a known Solifenacin succinate interaction (10 major, 117 moderate, 42 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 169. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Solifenacin succinate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Solifenacin succinate?
Plenty of supplements coexist fine with Solifenacin succinate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Vesicare have the same supplement interactions as Solifenacin succinate?
Yes — Vesicare all contain Solifenacin succinate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Solifenacin succinate and my other medications?
This page covers Solifenacin succinate against supplements and herbal ingredients. Checking Solifenacin succinate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Solifenacin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.