Medication interaction hub

What Supplements Interact with Disopyramide Phosphate?

Disopyramide Phosphate brand names: Norpace CR, Norpace. Every interaction below applies to the brands too.

169 Interactions 10 Major 117 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Disopyramide Phosphate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Disopyramide Phosphate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the first thing I would set aside on disopyramide phosphate (Norpace), a medicine that steadies dangerous heart rhythms, because grapefruit juice can push the drug's blood level up. That pattern dominates the page, since 121 of the 169 flagged ingredients act on the same liver enzyme, CYP3A4, raising the drug's level or, like St. John's wort, dropping it enough to weaken rhythm control. This is a list that calls for real care, not a quick skim.

The remaining risk splits three ways. Thirteen ingredients can stretch the heart's QT interval, the very rhythm problem disopyramide can cause on its own. Thirty add anticholinergic effects, meaning more dry mouth, constipation, and blurred vision than the drug alone brings. Seventeen, activated charcoal among them, can keep an oral dose from absorbing, so space those well apart. The 117 moderate and 42 minor entries echo these same themes at lower intensity, but the ten rated major are where your attention belongs.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 117 Minor 42 No known interaction 1,283

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Disopyramide Phosphate: Top Interactions at a Glance

The Disopyramide Phosphate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 169 interacting ingredients — plus 1,283 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Disopyramide Phosphate Combinations Today

The Disopyramide Phosphate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable Sida Cordifolia + Disopyramide Phosphatei

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Read the full interaction Major Likelihood Probable Arsenic + Disopyramide Phosphatei

Arsenic trioxide can prolong the QT interval.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Disopyramide Phosphatei

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Read the full interaction Minor Likelihood Unlikely Green Tea + Disopyramide Phosphatei

Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Disopyramide Phosphatei

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Disopyramide Phosphatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Disopyramide Phosphate

All 1,452 ingredients in our database, ranked by severity — 169 with a Disopyramide Phosphate interaction on file and 1,283 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Disopyramide Phosphate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Sida Cordifolia with Disopyramide Phosphate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Disopyramide Phosphate answer

Can you take Arsenic with Disopyramide Phosphate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Disopyramide Phosphate answer

Can you take Bitter Orange with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Disopyramide Phosphate answer

Can you take Green Tea with Disopyramide Phosphate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Green tea is unlikely to produce clinically significant changes in the levels and clinical effects of CYP3A4 substrates.

Full Green Tea + Disopyramide Phosphate answer

Can you take Eucalyptus with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Disopyramide Phosphate answer

Can you take Ayahuasca with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Disopyramide Phosphate answer

Can you take Bacopa with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Disopyramide Phosphate answer

Can you take Beet with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Disopyramide Phosphate answer

Can you take Berberine with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Disopyramide Phosphate answer

Can you take Beta-methylphenethylamine (bmpea) with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Disopyramide Phosphate answer

Can you take Bishop's Weed with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Disopyramide Phosphate answer

Can you take Black Pepper with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Disopyramide Phosphate answer

Can you take Bog Labrador Tea with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Disopyramide Phosphate answer

Can you take Boswellia Serrata with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Disopyramide Phosphate answer

Can you take Boxwood with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Disopyramide Phosphate answer

Can you take Bulbine Natalensis with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Disopyramide Phosphate answer

Can you take Calamus with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Disopyramide Phosphate answer

Can you take Cannabis with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Disopyramide Phosphate answer

Can you take Cat's Claw with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Disopyramide Phosphate answer

Can you take Ceylon Leadwort with Disopyramide Phosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Disopyramide Phosphate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Disopyramide Phosphate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Disopyramide Phosphate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Disopyramide Phosphate sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Disopyramide Phosphate through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Disopyramide Phosphate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Disopyramide Phosphate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Disopyramide Phosphate through this category.

About Disopyramide Phosphate

Disopyramide is an antiarrhythmic medicine used to treat life-threatening ventricular arrhythmias (dangerous irregular heart rhythms).

Generic name: Disopyramide Phosphate  ·  Brand names: Norpace CR, Norpace.

See the full Disopyramide drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Disopyramide Phosphate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Disopyramide Phosphate.

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Pharmacist Counseling Corner

Disopyramide Phosphate & Supplements: Common Questions

What supplements interact with Disopyramide Phosphate?
In our interaction database, 169 supplement and herbal ingredients have an interaction with Disopyramide Phosphate on file — 10 rated major, 117 moderate, and 42 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Disopyramide Phosphate supplement interactions are the most serious?
The 10 major-rated combinations — led by Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Disopyramide Phosphate?
That depends entirely on which supplement. The honest answer for Disopyramide Phosphate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Norpace CR have the same supplement interactions as Disopyramide Phosphate?
Yes — Norpace CR, Norpace all contain Disopyramide Phosphate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Disopyramide Phosphate and my other medications?
This page covers Disopyramide Phosphate against supplements and herbal ingredients. Checking Disopyramide Phosphate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Disopyramide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.