Drug & supplement interaction

Eucalyptus + Disopyramide Phosphate

Disopyramide Phosphate brand names: Norpace CR, Norpace.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Eucalyptus has a moderate interaction with Disopyramide Phosphate. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Eucalyptus and Disopyramide Phosphate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Disopyramide Phosphate

Disopyramide Phosphate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Eucalyptus interacts with.

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for disopyramide (Norpace). Your liver uses an enzyme called CYP3A4 to clear this drug out of your body. Lab and animal studies hint that eucalyptus oil might slow that enzyme down. If that happened in people, disopyramide could build up to higher levels than expected. Since this is a heart rhythm drug with a fairly narrow safety window, even modest increases matter. You might see more of its known side effects, like dry mouth, blurred vision, trouble urinating, constipation, dizziness, low blood pressure, or in some cases worsening rhythm problems.

The reassuring part: this is only a theoretical concern from test-tube work, never confirmed in humans. Still, given the drug involved, please check with your pharmacist or doctor before using eucalyptus regularly.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Eucalyptus Also Interacts With Other Medications

Eucalyptus has 877 moderate known drug interactions in our database — the Disopyramide Phosphate one above is one of them. If you take anything else, check it against the full list below.

Moderate 877 No known interaction 1,953 (incl. Disopyramide Phosphate)
Taking anything else?

Check Another of Your Medications Against Eucalyptus

Covers the 2,830 medications we’ve checked against Eucalyptus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Disopyramide Phosphate

This page covers Eucalyptus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Disopyramide Phosphate page lists 169 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 10 major · 117 moderate · 42 minor.

From our pharmacist’s overview on the Disopyramide Phosphate page

“Grapefruit is the first thing I would set aside on disopyramide phosphate (Norpace), a medicine that steadies dangerous heart rhythms, because grapefruit juice can push the drug's blood level up. That pattern dominates the page, since 121 of the 169 flagged ingredients act on the same liver enzyme, CYP3A4, raising the drug's level or,…”

Reviewed by 2 · Jul 18, 2026

Open the Disopyramide Phosphate interaction page

One more smart check

Taking Eucalyptus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 216 real supplement products containing Eucalyptus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Eucalyptus. Your product may carry other ingredients that interact with Disopyramide Phosphate too, on top of Eucalyptus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Eucalyptus and Disopyramide Phosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Eucalyptus
Top half

#383 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Disopyramide Phosphate
Steady interest

#1,900 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Eucalyptus

What is Eucalyptus?

Eucalyptus
  • Cough and chest congestion
  • Colds and flu symptoms
  • Stuffy nose
  • Sore throat
  • Minor muscle and joint aches
  • Aromatherapy

Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, short-term relief of cold symptoms, but the oil is toxic if swallowed and must never be taken by mouth undiluted. Talk to a pharmacist or doctor before using it, especially in children, during pregnancy, or while breastfeeding.

Read the full Eucalyptus monograph & all interactions
Medication

About Disopyramide

What Is Disopyramide Used For?

Brand names: Norpace CR, Norpace

Disopyramide — available as Disopyramide Phosphate, Norpace, and Norpace CR — is indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia (a fast, dangerous heart rhythm), that a physician judges to be life-threatening.

Because this drug can itself cause arrhythmias, it is not recommended for minor or symptom-free arrhythmias. Treatment is started in a hospital setting so the heart can be closely monitored. Antiarrhythmic drugs like disopyramide have not been shown to improve survival in patients with ventricular arrhythmias.

See full Disopyramide drug information
Keep checking

Other Drugs & Eucalyptus

Browse every other medication we’ve checked against Eucalyptus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
877Moderate
0Minor
1,952No known interaction
877 Moderate 1,952 No interaction
Moderate

877 interactions

Showing 60 of 877 moderate interactions — see all 877 on the Eucalyptus page.

No interaction 1,952 drugs checked — show the list

We also checked Eucalyptus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,952 medications checked with no known interaction — see the full Eucalyptus list.

See the full Eucalyptus interactions page
See every supplement checked against Disopyramide Phosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
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Pharmacist Counseling Corner

Taking Eucalyptus and Disopyramide Phosphate Together: Common Questions

Can you take Eucalyptus with Disopyramide Phosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Eucalyptus and Disopyramide Phosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Disopyramide Phosphate and Eucalyptus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.