Tea Tree Oil + Tofacitinib
Tofacitinib brand names: Xeljanz, Xeljanz XR.
We found no known interaction between Tea Tree Oil and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Tea Tree Oil and Tofacitinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tofacitinib and Tea Tree Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Tea Tree Oil at all — not against Tofacitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Tea Tree Oil safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Tea Tree Oil in Pregnancy & Breastfeeding
When used topically and appropriately.
When used orally. Ingestion of tea tree oil can be toxic.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Tofacitinib
This page covers Tea Tree Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).
By severity: 3 major · 143 moderate · 38 minor.
From our pharmacist’s overview on the Tofacitinib page
“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”
Reviewed by 2 · Jul 18, 2026
Where Tea Tree Oil and Tofacitinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,123 of 1,452 supplements looked up here in the last 7 days
#1,159 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tea Tree Oil reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tea Tree Oil and Tofacitinib records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Tea Tree Oil
What is Tea Tree Oil?
- Acne
- Fungal skin infections (athlete's foot, nail fungus)
- Dandruff
- Minor wounds and insect bites
- Lice
Tea tree oil is an essential oil used on the skin for acne, fungal infections, and other skin problems, with some supportive but limited evidence. It is for topical use only and should never be swallowed, as it can be toxic. Always dilute it, do a patch test first, and check with your pharmacist or doctor before using.
Melaleuca alternifolia · Myrtaceae · Leaves and twigs (steam-distilled into essential oil) · Essential oil, creams, gels, ointments, soaps, shampoos, mouthwash
An interaction check asks whether these two react with each other — it does not ask whether Tea Tree Oil is a good idea for someone in your situation. Here is what our Tea Tree Oil record says about it on its own.
Tea Tree Oil: dosing
There is no official standardized dose for tea tree oil. Many skin products contain it at low concentrations, often diluted to a small percentage of the total product.The safest approach is to follow the directions on the product label and not apply more or more often than directed. If you are using pure essential oil, dilute it with a carrier oil before use. Never take it by mouth.
From our Tea Tree Oil monograph — the full record covers uses, side effects and every documented interaction.
About Tofacitinib
What Is Tofacitinib Used For?
Brand names: Xeljanz, Xeljanz XR
-
Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults who are unable to take or did not respond to or tolerate one or more TNF inhibitor medication(s). Tofacitinib is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults who are unable to take or who did not respond to one or more TNF inhibitor medication(s). It is also used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years and older who are unable to take or who did not respond to one or more TNF inhibitor medication(s). Tofacitinib is in a class of medications called Janus kinase (JAK) inhibitors. It works by decreasing the activity of the immune system.
Other Drugs & Tea Tree Oil
Browse every other medication we’ve checked against Tea Tree Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Tea Tree Oil against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tea Tree Oil list.
Tea Tree Oil References
The 31 references that drive our Tea Tree Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999. DOI
- De Groot AC. Airborn allergic contact dermatitis from tea tree oil. Contact Dermatitis 1996;35:304-5.
- Rubel DM, Freeman S, Southwell IA. Tea tree oil allergy: what is the offending agent? Report of three cases of tea tree oil allergy and review of the literature. Australas J Dermatol 1998;39:244-7. PubMed
- Carson CF, Riley TV, Cookson BD. Efficacy and safety of tea tree oil as a topical antimicrobial agent. J Hosp Infect 1998;40:175-8. PubMed
- Bhushan M, Beck MH. Allergic contact dermatitis from tea tree oil in a wart paint. Contact Dermatitis 1997;36:117-8. PubMed
- Del Beccaro MA. Melaleuca oil poisoning in a 17-month-old. Vet Hum Toxicol 1995;37:557-8.
- Jandourek A, Vaishampayan JK, Vazquez JA. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. AIDS 1998;12:1033-7. DOI
- Zhang SY, Robertson D. A study of tea tree oil ototoxicity. Audiol Neurootol 2000;5:64-8. PubMed
- Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne. Med J Aust 1990;153:455-8. PubMed
- Jacobs MR, Hornfeldt CS. Melaleuca oil poisoning. J Toxicol Clin Toxicol 1994;32:461-4.. PubMed
- Elliott C. Tea tree oil poisoning. Med J Aust 1993;159:830-1. PubMed
- Knight TE, Hausen BM. Melaleuca oil (tea tree oil) dermatitis. J Am Acad Dermatol 1994;30:423-7.. PubMed
- Bruynzeel DP. Contact dermatitis due to tea tree oil. Trop Med Int Health 1999;4:630.
- Greig JE, Thoo SL, Carson CF, Riley TV. Allergic contact dermatitis following use of a tea tree oil hand-wash not due to tea tree oil. Contact Dermatitis 1999;41:354-5. PubMed
- Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
- Khanna M, Qasem K, Sasseville D. Allergic contact dermatitis to tea tree oil with erythema multiforme-like id reaction. Am J Contact Dermat 2000;11:238-42..
- Satchell AC, Saurajen A, Bell C, Barnetson RS. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol 2002;43:175-8.. PubMed
- Morris MC, Donoghue A, Markowitz JA, Osterhoudt KC. Ingestion of tea tree oil (Melaleuca oil) by a 4-year-old boy. Pediatr Emerg Care 2003;19:169-71. PubMed
- Martin KW, Ernst E. Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials. Mycoses 2004;47:87-92. PubMed
- De Groot A. C. and Weyland J. W. Systemic contact dermatitis from tea tree oil. Contact Dermatitis 1992;27(4):279-280. PubMed
- Enshaieh S, Jooya A, Siadat AH, and Iraji F. The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007;73(1):22-25. PubMed
- Christoffers WA, Blömeke B, Coenraads PJ, Schuttelaar ML. Co-sensitization to ascaridole and tea tree oil. Contact Dermatitis. 2013 Sep;69(3):187-9. PubMed
- Corazza M, Borghi A, Gallo R, Schena D, Pigatto P, Lauriola MM, Guarneri F, Stingeni L, Vincenzi C, Foti C, Virgili A. Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study. Contact Dermatiti
- Kwon HH, Yoon JY, Park SY, Min S, Suh DH. Comparison of clinical and histological effects between lactobacillus-fermented Chamaecyparis obtusa and tea tree oil for the treatment of acne: an eight-week double-blind randomized controlled split-face study. D PubMed
- Martínez Campayo N, Goday Buján JJ, Fonseca Capdevila E. Allergic contact dermatitis due to tea tree oil. Actas Dermosifiliogr (Engl Ed). 2020;111(9):787-788. DOI
- Lauriola MM, Sena P, De Bitonto A, Corazza M. Allergic contact dermatitis due to "therapeutic uses" of tea tree oil on the lips and toenails. Dermatitis. 2021;32(3):e40-e41. PubMed
- Navarro-Triviño FJ, Prados-Carmona Á, Ruiz-Villaverde R. Systemic allergic contact dermatitis caused by tea tree oil in a cream for treatment of molluscum contagiosum. Contact Dermatitis 2022;87(3):285-287. PubMed
- Bekhof AMW, van Hunsel FPAM, van de Koppel S, Woerdenbag HJ. Safety assessment and adverse drug reaction reporting of tea tree oil (Melaleuca aetheroleum). Phytother Res 2022.
- Ambrogio F, Foti C, Cazzato G, et al. Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart. Medicina (Kaunas) 2022;58(5):561. PubMed
- Samaran Q, Litovsky J, Girod M, Dereure O, Raison-Peyron N. Allergic Contact Dermatitis to Tea Tree Oil With No Sensitization to Fragrance Markers. Dermatitis 2023. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Tea Tree Oil and Tofacitinib Together: Common Questions
Is it safe to take Tea Tree Oil with Tofacitinib?
Do Tea Tree Oil and Tofacitinib have any of the same side effects?
Does Tofacitinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.