Tetrahydrocannabivarin (thcv) + Macitentan
Macitentan brand name: Opsumit.
We found no known interaction between Tetrahydrocannabivarin (thcv) and Macitentan in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Tetrahydrocannabivarin (thcv) and Macitentan
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Macitentan and Tetrahydrocannabivarin (thcv) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Tetrahydrocannabivarin (thcv) at all — not against Macitentan, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Tetrahydrocannabivarin (thcv) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Macitentan
This page covers Tetrahydrocannabivarin (thcv) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Macitentan page lists 253 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Beer (major) and Grapefruit (major).
By severity: 9 major · 205 moderate · 39 minor.
From our pharmacist’s overview on the Macitentan page
“If you take macitentan (Opsumit) for pulmonary arterial hypertension, study this page rather than skim it. It lists 253 supplement and herbal ingredients, nine rated major.”
Reviewed by 2 · Jul 18, 2026
Where Tetrahydrocannabivarin (thcv) and Macitentan Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#930 of 1,452 supplements looked up here in the last 7 days
#598 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Tetrahydrocannabivarin (thcv) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tetrahydrocannabivarin (thcv) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Tetrahydrocannabivarin (thcv) and Macitentan records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Tetrahydrocannabivarin (thcv)
What is Tetrahydrocannabivarin (thcv)?
- Appetite control and weight management
- Blood sugar support
- Energy and focus
- General wellness
Tetrahydrocannabivarin (THCV) is a minor cannabinoid found in cannabis that is being studied for appetite, metabolism, and blood sugar, but human evidence is very limited. Product quality, legal status, and dosing vary widely, so talk with your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.
Cannabis sativa · Cannabaceae · Flowers and leaves of the cannabis plant (THCV is an extracted or isolated cannabinoid) · Oils, tinctures, capsules, gummies, vape products, and isolated extracts
An interaction check asks whether these two react with each other — it does not ask whether Tetrahydrocannabivarin (thcv) is a good idea for someone in your situation. Here is what our Tetrahydrocannabivarin (thcv) record says about it on its own.
Tetrahydrocannabivarin (thcv): dosing
There is no established standard dose for THCV. Research is too limited to recommend a specific milligram amount, and effects may even differ between low and high doses.If you choose to try a product, follow the directions on the label and start with the lowest amount.
From our Tetrahydrocannabivarin (thcv) monograph — the full record covers uses, side effects and every documented interaction.
About Macitentan
What Is Macitentan Used For?
Brand name: Opsumit
Macitentan tablets — sold under the brand name Opsumit — are used to treat pulmonary arterial hypertension (PAH, WHO Group I), a type of high blood pressure in the arteries of the lungs. The goal is to slow the disease from getting worse and to lower the chance of being hospitalized because of PAH.
In the key clinical study, macitentan was used in adults with mainly moderate-to-severe PAH symptoms. Patients had PAH caused by unknown or inherited causes, connective tissue disorders, or congenital heart disease with repaired shunts.
Most-Reported Side Effects for Macitentan
From FAERS, the FDA’s public side-effect reporting system (68,860 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Tetrahydrocannabivarin (thcv)
Browse every other medication we’ve checked against Tetrahydrocannabivarin (thcv) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Tetrahydrocannabivarin (thcv) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Amlodipine Besylate ›
- Docusate ›
- Methamphetamine ›
- Amitriptyline ›
- Prednisone ›
- Metformin ›
- Tadalafil ›
- Lisdexamfetamine ›
- Semaglutide ›
- Hydroxyurea ›
- Valacyclovir ›
- Amphetamine ›
- Sumatriptan ›
- Propranolol ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Acetaminophen, Aspirin, Caffeine ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Lamotrigine ›
- Bendamustine ›
- Quetiapine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tetrahydrocannabivarin (thcv) list.
Tetrahydrocannabivarin (thcv) References
The 2 sources that drive our Tetrahydrocannabivarin (thcv) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Tetrahydrocannabivarin (thcv) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Cannabis (Marijuana) and Cannabinoids: What You Need To Know — NIH NCCIH Source
- Marijuana — MedlinePlus Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Macitentan Is Linked to Lower Levels of One Nutrient
Natural Medicines records Macitentan as a medicine that can lower these. This is not an interaction with Tetrahydrocannabivarin (thcv) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Macitentan nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Tetrahydrocannabivarin (thcv) and Macitentan Together: Common Questions
Is it safe to take Tetrahydrocannabivarin (thcv) with Macitentan?
Does Macitentan interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.