Trendione + Rotigotine
Rotigotine brand name: Neupro.
We found no known interaction between Trendione and Rotigotine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Trendione and Rotigotine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Rotigotine and Trendione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Trendione at all — not against Rotigotine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Trendione safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Trendione in Pregnancy & Breastfeeding
When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Rotigotine
This page covers Trendione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rotigotine page lists 7 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Ayahuasca (moderate), Black Horehound (moderate), Dimethylsulfoxide (dmso) (moderate), Syrian Rue (moderate) and Turpentine Oil (moderate).
By severity: 6 moderate · 1 minor.
From our pharmacist’s overview on the Rotigotine page
“Rotigotine (Neupro) treats Parkinson's disease and restless legs through a skin patch, and the seven supplement interactions on file split along those two facts. None rates major, six are moderate and one minor, so this reads as a watch list rather than a stop list.”
Reviewed by 2 · Jul 18, 2026
Where Trendione and Rotigotine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,210 of 1,452 supplements looked up here in the last 7 days
#1,402 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Trendione reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Trendione and Rotigotine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Trendione
What is Trendione?
- Muscle building
- Strength gains
- Body recomposition
- Athletic performance
Trendione (also marketed as estra-4,9,11-trien-3,17-dione) is a synthetic anabolic steroid sold as a so-called "prohormone" or "designer steroid," not a natural herb or vitamin. It is not a legitimate dietary supplement, has not been proven safe in humans, and is linked to potentially serious side effects, including liver harm. We strongly advise against using it and recommend talking with your doctor or pharmacist.
Not applicable; Trendione is a synthetic steroid compound, not a plant part · Capsules, tablets, oral powders (sold as a bodybuilding supplement)
An interaction check asks whether these two react with each other — it does not ask whether Trendione is a good idea for someone in your situation. Here is what our Trendione record says about it on its own.
Trendione: dosing
There is no established safe or effective dose for Trendione. Because it is a synthetic steroid rather than a studied medicine, no health authority has set a recommended amount.We do not provide dosing for this product because we do not recommend using it.
From our Trendione monograph — the full record covers uses, side effects and every documented interaction.
About Rotigotine Transdermal Patch
What Is Rotigotine Transdermal Patch Used For?
Brand name: Neupro
Neupro (rotigotine transdermal patch) is approved to treat Parkinson's disease — both early-stage and advanced-stage — helping to manage the movement symptoms associated with this condition.
Neupro is also approved for moderate-to-severe primary Restless Legs Syndrome (RLS), a condition that causes uncomfortable urges to move the legs, especially at rest or at night.
Most-Reported Side Effects for Rotigotine
From FAERS, the FDA’s public side-effect reporting system (14,378 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Trendione
Browse every other medication we’ve checked against Trendione — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Trendione against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Clonazepam ›
- Quetiapine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Trendione list.
Trendione References
The 1 references that drive our Trendione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Trendione and Rotigotine Together: Common Questions
Is it safe to take Trendione with Rotigotine?
Does Rotigotine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Rotigotine and Trendione?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.