Medication interaction hub

What Supplements Interact with Rotigotine?

Rotigotine brand name: Neupro. Every interaction below applies to the brands too.

7 Interactions 6 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rotigotine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rotigotine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rotigotine (Neupro) treats Parkinson's disease and restless legs through a skin patch, and the seven supplement interactions on file split along those two facts. None rates major, six are moderate and one minor, so this reads as a watch list rather than a stop list. Four ingredients, vitex agnus-castus among them, may add dopamine activity of their own, pushing the medicine's effects and side effects further than your dose intends. The other three involve the skin route, with DMSO the standout for pulling other drugs through skin faster.

Keep anything containing DMSO away from where your patch sits; speeding rotigotine's absorption is not what you want. Evidence for all seven is preliminary, mostly animal and lab research, so treat them as theoretical concerns rather than proven problems. Mention any of the herbs below to your pharmacist, and if you start one, watch for stronger dopamine effects such as nausea or drowsiness.

— , Clinical Pharmacist · July 18, 2026

Moderate 6 Minor 1 No known interaction 1,445

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Rotigotine: Top Interactions at a Glance

The most significant Rotigotine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 7 highest-ranked of 7 interacting ingredients — plus 1,445 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Rotigotine + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Possible Ayahuasca + Rotigotinei

Theoretically, ayahuasca might have additive effects when used with dopamine agonists.

Read the full interaction Moderate Likelihood Possible Black Horehound + Rotigotinei

Theoretically, black horehound might have additive effects when used with dopamine agonists.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + Rotigotinei

Topical DMSO might increase the effects and adverse effects of topical drugs.

Read the full interaction Moderate Likelihood Possible Syrian Rue + Rotigotinei

Theoretically, Syrian rue might increase the adverse effects of dopamine agonists.

Read the full interaction Moderate Likelihood Possible Turpentine Oil + Rotigotinei

Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine or haloperidol when...

Read the full interaction Moderate Likelihood Possible Vitex Agnus-castus + Rotigotinei

Theoretically, vitex agnus-castus could interfere with dopamine agonists.

Read the full interaction
The complete list

Every Supplement Checked Against Rotigotine

All 1,452 ingredients in our database, ranked by severity — 7 with a Rotigotine interaction on file and 1,445 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rotigotine?

One-line answers, one card per combination — scroll through today’s 12 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Dimethylsulfoxide (dmso) with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Rotigotine answer

Can you take Syrian Rue with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the adverse effects of dopamine agonists.

Full Syrian Rue + Rotigotine answer

Can you take Turpentine Oil with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Rotigotine answer

Can you take Vitex Agnus-castus with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with dopamine agonists.

Full Vitex Agnus-castus + Rotigotine answer

Can you take Alchemilla with Rotigotine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Rotigotine answer

Can you take Ayahuasca with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might have additive effects when used with dopamine agonists.

Full Ayahuasca + Rotigotine answer

Can you take Black Horehound with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black horehound might have additive effects when used with dopamine agonists.

Full Black Horehound + Rotigotine answer

Can you take Dimethylsulfoxide (dmso) with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Rotigotine answer

Can you take Syrian Rue with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the adverse effects of dopamine agonists.

Full Syrian Rue + Rotigotine answer

Can you take Turpentine Oil with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Rotigotine answer

Can you take Vitex Agnus-castus with Rotigotine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with dopamine agonists.

Full Vitex Agnus-castus + Rotigotine answer

Can you take Alchemilla with Rotigotine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Rotigotine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rotigotine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rotigotine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rotigotine sits in 2 interaction categories. Open any one to see what the group means:

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Rotigotine through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Rotigotine through this category.

About Rotigotine

Rotigotine is a dopamine agonist delivered through a daily skin patch (Neupro) used to treat Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome.

Generic name: Rotigotine  ·  Brand name: Neupro.

See the full Rotigotine Transdermal Patch drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rotigotine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rotigotine.

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Pharmacist Counseling Corner

Rotigotine & Supplements: Common Questions

What supplements interact with Rotigotine?
More than you might expect — 7 in total, though they are far from equal: 0 are rated major, 6 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Ayahuasca, Black Horehound, Dimethylsulfoxide (dmso).
Which Rotigotine supplement interactions are the most serious?
None of the Rotigotine supplement interactions on file are currently rated major. The most significant are the 6 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Rotigotine?
Usually yes — most people on Rotigotine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Neupro have the same supplement interactions as Rotigotine?
Yes — Neupro all contain Rotigotine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Rotigotine and my other medications?
This page covers Rotigotine against supplements and herbal ingredients. Checking Rotigotine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Rotigotine Transdermal Patch drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.