Drug & supplement interaction

1-androsterone + Rotigotine

Rotigotine brand name: Neupro.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 1-androsterone and Rotigotine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

1-androsterone and Rotigotine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rotigotine and 1-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1-androsterone safety at a glance

1-androsterone overall Avoid It is a hormonal compound with real health risks and little safety testing.
Pregnancy Avoid Hormone-altering prohormones should never be used during pregnancy.
Breastfeeding Avoid Avoid while breastfeeding because of unknown hormonal risks to the baby.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rotigotine and 1-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Rotigotine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Rotigotine is filed under 2 classifications — dopamine agonists, topical drugs. 1-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Rotigotine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1-androsterone Does Interact With Other Medications

1-androsterone has 8 moderate known drug interactions in our database — Rotigotine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Rotigotine)
Taking anything else?

Check Another of Your Medications Against 1-androsterone

Covers the 2,830 medications we’ve checked against 1-androsterone. Pick one to open its full report.

What to actually watch for

What 1-androsterone Itself Has Been Linked To

This is not an interaction — nothing below involves Rotigotine. It is the side-effect record for 1-androsterone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1-androsterone, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Significant increases in serum creatinine of around 0.2 mg/dL and significant decreases in GFR of around 16.4 mL/min/1.72m2 have been reported in patients taking 1-androsterone for 4 weeks. Serum creatinine remained within normal range despite the elevation, GFR dropped below 89 mL/min/1.72m2, which is suggestive of renal impairment.”

    1-androsterone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 91095. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.
  • Liver problems Worth acting on Additional detail

    “There is currently a limited amount of information on the adverse effects of 1-androsterone. A thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Dyslipidemia, transaminitis, renal dysfunction.”

    1-androsterone · Natural Medicines adverse-effect record, reported in dyslipidemia.

Everything above comes from the Natural Medicines adverse-effect record for 1-androsterone — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Rotigotine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Rotigotine column appears here.

Everything else you take

See Every Supplement That Interacts With Rotigotine

This page covers 1-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rotigotine page lists 7 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Ayahuasca (moderate), Black Horehound (moderate), Dimethylsulfoxide (dmso) (moderate), Syrian Rue (moderate) and Turpentine Oil (moderate).

By severity: 6 moderate · 1 minor.

From our pharmacist’s overview on the Rotigotine page

“Rotigotine (Neupro) treats Parkinson's disease and restless legs through a skin patch, and the seven supplement interactions on file split along those two facts. None rates major, six are moderate and one minor, so this reads as a watch list rather than a stop list.”

Reviewed by 2 · Jul 18, 2026

Open the Rotigotine interaction page

One more smart check

Taking 1-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 35 real supplement products containing 1-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 1-androsterone. Even though 1-androsterone itself has no known interaction with Rotigotine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 1-androsterone and Rotigotine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1-androsterone
Steady interest

#848 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rotigotine
Top half

#1,248 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 1-androsterone and Rotigotine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1-androsterone

What is 1-androsterone?

1-androsterone
  • Muscle building
  • Increasing strength
  • Athletic performance
  • Body recomposition

1-Androsterone (1-DHEA or 1-Andro) is a synthetic prohormone marketed to bodybuilders for muscle and strength gains, but it has not been proven safe or effective in quality human studies. It can affect hormones and may harm the liver and other organs, so most pharmacists would recommend avoiding it.

Synthetic compound (not a plant part) · Capsules, tablets, sometimes combined with other prohormones

An interaction check asks whether these two react with each other — it does not ask whether 1-androsterone is a good idea for someone in your situation. Here is what our 1-androsterone record says about it on its own.

1-androsterone: dosing

There is no established safe or standard dose for 1-androsterone, and no medical guideline supports its use. Products vary widely in strength and ingredients.Because of the health risks involved, the safest choice for most people is not to use it at all. Never combine it with other prohormones or hormone products.

From our 1-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1-androsterone monograph & all interactions
Medication

About Rotigotine Transdermal Patch

What Is Rotigotine Transdermal Patch Used For?

Brand name: Neupro

Neupro (rotigotine transdermal patch) is approved to treat Parkinson's disease — both early-stage and advanced-stage — helping to manage the movement symptoms associated with this condition.

Neupro is also approved for moderate-to-severe primary Restless Legs Syndrome (RLS), a condition that causes uncomfortable urges to move the legs, especially at rest or at night.

Most-Reported Side Effects for Rotigotine

From FAERS, the FDA’s public side-effect reporting system (14,378 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Product adhesion issue 1,911 reports
Fall 983 reports
Parkinson^s disease 775 reports
Hallucination 730 reports
Dyskinesia 668 reports
See full Rotigotine Transdermal Patch drug information
Keep checking

Other Drugs & 1-androsterone

Browse every other medication we’ve checked against 1-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 1-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 1-androsterone list.

See the full 1-androsterone interactions page
See every supplement checked against Rotigotine, ranked by severity
Evidence & sources

1-androsterone References

The 2 references that drive our 1-androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Parr MK, Opfermann G, Geyer H, et al. Seized designer supplement named "1-Androsterone": identification as 3ß-hydroxy-5a-androst-1-en-17-one and its urinary elimination. Steroids 2011;76(6):540-7.
  2. Granados J, Gillum TL, Christmas KM, et al. Prohormone supplement 3b-hydroxy-5a-androst-1-en-17-one enhances resistance training gains but impairs user health. J Appl Physiol (1985). 2014;116(5):560-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1-androsterone and Rotigotine Together: Common Questions

Is it safe to take 1-androsterone with Rotigotine?
We do not list a known interaction between 1-androsterone and Rotigotine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1-androsterone and Rotigotine combination checked?
Interactions in our licensed database are recorded against drug classes. Rotigotine is filed under 2 classifications, and 1-androsterone has documented interactions with 1 drug class — none of Rotigotine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1-androsterone interact with any other medications?
Yes. 1-androsterone has 8 documented drug interactions in our database — Rotigotine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Rotigotine interact with any supplements?
Yes. Rotigotine has documented interactions with 7 supplements in our database — 1-androsterone is not one of them. The Rotigotine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1-androsterone monograph Uses, safety profile, and every drug interaction in one place Rotigotine Transdermal Patch drug information The full plain-English guide to this medication Rotigotine supplement interactions Every supplement checked against Rotigotine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rotigotine and 1-androsterone?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.