Drug & supplement interaction

Wasabi + Zolpidem Tartrate

Zolpidem Tartrate brand name: Ambien.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Wasabi and Zolpidem Tartrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Zolpidem Tartrate states a food rule worth keeping to.

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Interaction report

Wasabi and Zolpidem Tartrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zolpidem Tartrate and Wasabi in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wasabi safety at a glance

Wasabi overall Use caution Generally safe as a food, but supplement-strength doses are not well studied in people.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplements due to a lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but supplement doses have not been studied, so caution is best.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zolpidem Tartrate and Wasabi? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Zolpidem Tartrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Zolpidem Tartrate is filed under 4 classifications — including cns depressants, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Wasabi has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Zolpidem Tartrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wasabi Does Interact With Other Medications

Wasabi has 122 moderate known drug interactions in our database — Zolpidem Tartrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Zolpidem Tartrate)
Taking anything else?

Check Another of Your Medications Against Wasabi

Covers the 2,830 medications we’ve checked against Wasabi. Pick one to open its full report.

What to actually watch for

What Wasabi Itself Has Been Linked To

This is not an interaction — nothing below involves Zolpidem Tartrate. It is the side-effect record for Wasabi on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Wasabi, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “A small clinical study in adults taking oral wasabi extract 1000 mg once daily for 4 weeks has found 2 cases of proteinuria.”

    Wasabi · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 112846. Nakajima R, Kanou M, Tokushima M, Iwama Y, Yamana K. Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers. Biopsychosoc Med 2023;17(1):30. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Wasabi — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Zolpidem Tartrate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Zolpidem Tartrate column appears here.

How to take them

Some Zolpidem Tartrate Products Have a Food Rule — Wasabi Should Not Break It

At least one FDA label for a product containing Zolpidem Tartrate says to take it with food. If you take Wasabi on an empty stomach out of habit, keep them separate — and take Zolpidem Tartrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Zolpidem Tartrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Administration The effect of Zolpidem Tartrate Tablets may be slowed by ingestion with or immediately after a meal.

From the Dosage and Administration section of the FDA label we read for Zolpidem Tartrate — where that label names a specific product, the instruction is that product's. See the Zolpidem Tartrate drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Wasabi or Zolpidem Tartrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wasabi or Zolpidem Tartrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Zolpidem Tartrate

This page covers Wasabi only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zolpidem Tartrate page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

Open the Zolpidem Tartrate interaction page

How much people look this up

Where Wasabi and Zolpidem Tartrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wasabi
Top half

#663 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zolpidem Tartrate
Steady interest

#1,756 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wasabi reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Wasabi and Zolpidem Tartrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wasabi

What is Wasabi?

Wasabi
  • Flavoring for sushi and other foods
  • Antimicrobial support
  • Anti-inflammatory support
  • Antioxidant support
  • General immune support

Wasabi is best known as the pungent green condiment served with sushi, made from a Japanese plant in the cabbage family. Its natural compounds (isothiocyanates) show antimicrobial and antioxidant activity in lab studies, but there is very little human research to support taking it as a supplement. As a food it is generally safe; as a concentrated supplement, talk with your pharmacist or doctor first.

Eutrema japonicum · Brassicaceae · Rhizome (root stem), and sometimes the leaves and stalks · Fresh paste, dried powder, capsules, extracts, and as a culinary condiment

An interaction check asks whether these two react with each other — it does not ask whether Wasabi is a good idea for someone in your situation. Here is what our Wasabi record says about it on its own.

Wasabi: dosing

There is no established standard dose for wasabi as a supplement. Research has not identified a safe and effective amount for any specific health purpose.If you choose to use a wasabi product, follow the directions on the label and do not exceed the recommended amount.

From our Wasabi monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wasabi monograph & all interactions
Medication

About Zolpidem

What Is Zolpidem Used For?

Brand name: Ambien

Zolpidem is used short-term for insomnia. Most formulations — including Ambien, oral tablets, and Zolpidem Tartrate Capsules — are approved to help people who have trouble falling asleep at bedtime. Zolpidem Tartrate Capsules are specifically indicated for adults under 65.

The extended-release formulations (including Zolpidem Tartrate Extended-Release Tablets) help with both falling asleep and staying asleep through the night. Sublingual tablets (Edluar, Zolpidem Tartrate Sublingual Tablet, and Zolpidem tartrate sublingual) are taken as needed when you wake up in the middle of the night and cannot get back to sleep — but only if at least 4 hours of sleep time remain before you need to be up.

Most-Reported Side Effects for Zolpidem Tartrate

From FAERS, the FDA’s public side-effect reporting system (134,360 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 8,545 reports
Fatigue 8,298 reports
Insomnia 6,338 reports
Headache 6,332 reports
Diarrhea 5,966 reports
See full Zolpidem drug information
Keep checking

Other Drugs & Wasabi

Browse every other medication we’ve checked against Wasabi — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Wasabi page.

No interaction 2,707 drugs checked — show the list

We also checked Wasabi against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Wasabi list.

See the full Wasabi interactions page
See every supplement checked against Zolpidem Tartrate, ranked by severity
Evidence & sources

Wasabi References

The 2 references that drive our Wasabi monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Morimitsu, Y., Hayashi, K., Nakagawa, Y., Fujii, H., Horio, F., Uchida, K., and Osawa, T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi. Mech Ageing Dev 2000;116(2-3):125-134. PubMed
  2. Nakajima R, Kanou M, Tokushima M, Iwama Y, Yamana K. Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers. Biopsychosoc Med 2023;17(1):30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wasabi and Zolpidem Tartrate Together: Common Questions

Is it safe to take Wasabi with Zolpidem Tartrate?
We do not list a known interaction between Wasabi and Zolpidem Tartrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Wasabi and Zolpidem Tartrate at the same time of day?
At least one FDA label for a product containing Zolpidem Tartrate says to take it with food. If you take Wasabi on an empty stomach out of habit, keep them separate and take Zolpidem Tartrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Zolpidem Tartrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Wasabi and Zolpidem Tartrate combination checked?
Interactions in our licensed database are recorded against drug classes. Zolpidem Tartrate is filed under 4 classifications, and Wasabi has documented interactions with 1 drug class — none of Zolpidem Tartrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wasabi interact with any other medications?
Yes. Wasabi has 122 documented drug interactions in our database — Zolpidem Tartrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Zolpidem Tartrate interact with any supplements?
Yes. Zolpidem Tartrate has documented interactions with 195 supplements in our database — Wasabi is not one of them. The Zolpidem Tartrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wasabi monograph Uses, safety profile, and every drug interaction in one place Zolpidem drug information The full plain-English guide to this medication Zolpidem Tartrate supplement interactions Every supplement checked against Zolpidem Tartrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zolpidem Tartrate and Wasabi?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.