Drug & supplement interaction

Water Avens + Cabozantinib S-Malate

Cabozantinib S-Malate brand name: Cabometyx.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Water Avens and Cabozantinib S-Malate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Water Avens and Cabozantinib S-Malate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cabozantinib S-Malate and Water Avens in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Water Avens at all — not against Cabozantinib S-Malate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Water Avens safety at a glance

Water Avens overall Not established Little modern safety data exists, so caution is advised.

Pregnancy Avoid Safety is not established, so avoid use during pregnancy.

Breastfeeding Avoid Safety is not established, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cabozantinib S-Malate and Water Avens? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

What to actually watch for

What Cabozantinib S-Malate’s Own FDA Label Lists

This is not an interaction — none of it involves Water Avens. These are the most notable effects listed in the ADVERSE REACTIONS section of Cabozantinib S-Malate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Low magnesium Worth acting on
A change in thyroid levels Worth acting on
Low sodium Worth acting on
Low potassium Worth acting on
Heart failure Worth acting on
Raised blood pressure Worth acting on mentioned in 6.7% of FDA reports for Cabozantinib S-Malate
Kidney problems Worth acting on
Anemia Worth acting on
A low white blood cell count Worth acting on
Liver problems Worth acting on

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cabozantinib S-Malate. Read the label on DailyMed › Where a percentage is shown, it is the share of 47,766 voluntary FDA FAERS reports for Cabozantinib S-Malate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Water Avens’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Water Avens side to compare — that is a limit of the record, not a statement that Water Avens has no side effects.

Everything else you take

See Every Supplement That Interacts With Cabozantinib S-Malate

This page covers Water Avens only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cabozantinib S-Malate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Cabozantinib S-Malate page

“Cabozantinib (Cabometyx) treats kidney, liver, and thyroid cancers, and because its dosing is calibrated carefully, its supplement list warrants genuine care. Of the 138 ingredients with a known interaction, the great majority involve the CYP3A4 enzyme that clears the drug, so an herb can push cabozantinib levels high enough to worsen…”

Reviewed by 2 · Jul 18, 2026

Open the Cabozantinib S-Malate interaction page

How much people look this up

Where Water Avens and Cabozantinib S-Malate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Water Avens

Steady interest

#919 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Cabozantinib S-Malate

Steady interest

#2,200 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Water Avens is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Water Avens reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Water Avens and Cabozantinib S-Malate records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Water Avens

What is Water Avens?

Diarrhea and digestive upset
Sore throat and mouth irritation
Mild fever
General tonic
Astringent for minor wounds

Water avens is a traditional herb whose root has been used as an astringent for diarrhea, sore throats, and digestive complaints. There is very little modern scientific research to confirm that it works or to define a safe dose, so use it cautiously and talk with a pharmacist or doctor first.

Geum rivale · Rosaceae · Root and rhizome (occasionally aerial parts) · Dried root, tea/decoction, tincture

An interaction check asks whether these two react with each other — it does not ask whether Water Avens is a good idea for someone in your situation. Here is what our Water Avens record says about it on its own.

Water Avens: dosing

There is no established or standardized dose for water avens. Traditional use involved teas (decoctions) of the dried root or tinctures, but reliable, research-based dosing is not available.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Water Avens monograph — the full record covers uses, side effects and every documented interaction.

Read the full Water Avens monograph & all interactions

Medication

About Cabozantinib

What Is Cabozantinib Used For?

Brand name: Cabometyx

Cabozantinib treats several types of cancer. Cabometyx (tablet) is used for advanced renal cell carcinoma (kidney cancer) — either alone or combined with nivolumab as a first-line treatment — as well as hepatocellular carcinoma (liver cancer) in patients previously treated with sorafenib, differentiated thyroid cancer that has progressed after prior therapy, and pancreatic or extra-pancreatic neuroendocrine tumors (NETs) that have been previously treated. For thyroid cancer and NETs, Cabometyx is approved for adults and adolescents aged 12 and older.

Cometriq (capsule) is approved specifically for progressive, metastatic medullary thyroid cancer (a different type of thyroid cancer). Cometriq and Cabometyx are not interchangeable — do not substitute one for the other.

See full Cabozantinib drug information

Keep checking

Other Drugs & Water Avens

Browse every other medication we’ve checked against Water Avens — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

0Moderate

0Minor

2,829No known interaction

2,829 No interaction

No interaction 2,829 drugs checked — show the list

We also checked Water Avens against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Water Avens list.

See the full Water Avens interactions page

See every supplement checked against Cabozantinib S-Malate, ranked by severity

Evidence & sources

Water Avens References

The 2 sources that drive our Water Avens monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Water Avens is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Water Avens and Cabozantinib S-Malate Together: Common Questions

Is it safe to take Water Avens with Cabozantinib S-Malate?

We do not list a known interaction between Water Avens and Cabozantinib S-Malate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Cabozantinib S-Malate interact with any supplements?

Yes. Cabozantinib S-Malate has documented interactions with 138 supplements in our database — Water Avens is not one of them. The Cabozantinib S-Malate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Water Avens monograph Uses, safety profile, and every drug interaction in one place Cabozantinib drug information The full plain-English guide to this medication Cabozantinib S-Malate supplement interactions Every supplement checked against Cabozantinib S-Malate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cabozantinib S-Malate and Water Avens?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.