Medication interaction hub

What Supplements Interact with Cabozantinib S-Malate?

Cabozantinib S-Malate brand name: Cabometyx. Every interaction below applies to the brands too.

138 Interactions 3 Major 94 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated October 7, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cabozantinib S-Malate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cabozantinib S-Malate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Cabozantinib (Cabometyx) treats kidney, liver, and thyroid cancers, and because its dosing is calibrated carefully, its supplement list warrants genuine care. Of the 138 ingredients with a known interaction, the great majority involve the CYP3A4 enzyme that clears the drug, so an herb can push cabozantinib levels high enough to worsen side effects or drop them low enough to undercut the cancer treatment itself. Grapefruit and St. John's wort are the everyday items rated major, one raising levels, the other lowering them.

The third major entry is activated charcoal, which can bind the dose in the gut. A smaller cluster of 17 ingredients, fibers and charcoals among them, interferes with how oral medicines absorb, so space those well apart from your dose. Only 3 of the 138 rate major, alongside 94 moderate and 41 minor, but with a drug this consequential, clear each supplement with the oncology team before starting it.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 94 Minor 41 No known interaction 1,314

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cabozantinib S-Malate: Top Interactions at a Glance

The Cabozantinib S-Malate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 138 interacting ingredients — plus 1,314 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cabozantinib S-Malate Combinations Today

The Cabozantinib S-Malate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Kava + Cabozantinib S-Malatei

It is unclear if kava inhibits CYP3AA; research is conflicting.

Read the full interaction Moderate Likelihood Possible Quercetin + Cabozantinib S-Malatei

Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Cabozantinib S-Malatei

Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Evodia + Cabozantinib S-Malatei

Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Cabozantinib S-Malatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Cabozantinib S-Malatei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Cabozantinib S-Malate

All 1,452 ingredients in our database, ranked by severity — 138 with a Cabozantinib S-Malate interaction on file and 1,314 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cabozantinib S-Malate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kava with Cabozantinib S-Malate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP3AA; research is conflicting.

Full Kava + Cabozantinib S-Malate answer

Can you take Quercetin with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Full Quercetin + Cabozantinib S-Malate answer

Can you take Cannabidiol (cbd) with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Cabozantinib S-Malate answer

Can you take Evodia with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Cabozantinib S-Malate answer

Can you take European Barberry with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Cabozantinib S-Malate answer

Can you take False Unicorn with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Cabozantinib S-Malate answer

Can you take Fennel with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

Full Fennel + Cabozantinib S-Malate answer

Can you take Feverfew with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Cabozantinib S-Malate answer

Can you take Fo-ti with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Fo-ti + Cabozantinib S-Malate answer

Can you take Garlic with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Cabozantinib S-Malate answer

Can you take German Chamomile with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Cabozantinib S-Malate answer

Can you take Ginger with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Cabozantinib S-Malate answer

Can you take Ginkgo with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.

Full Ginkgo + Cabozantinib S-Malate answer

Can you take Goji with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Cabozantinib S-Malate answer

Can you take Goldenseal with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP3A4.

Full Goldenseal + Cabozantinib S-Malate answer

Can you take Goldthread with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Cabozantinib S-Malate answer

Can you take Grape with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.

Full Grape + Cabozantinib S-Malate answer

Can you take Guar Gum with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Cabozantinib S-Malate answer

Can you take Gum Arabic with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Cabozantinib S-Malate answer

Can you take Higenamine with Cabozantinib S-Malate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Cabozantinib S-Malate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cabozantinib S-Malate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cabozantinib S-Malate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cabozantinib S-Malate sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Cabozantinib S-Malate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Cabozantinib S-Malate through this category.

About Cabozantinib S-Malate

Cabozantinib is a kinase inhibitor (a targeted cancer medicine) used for advanced kidney cancer, liver cancer, certain thyroid cancers and certain neuroendocrine tumors, depending on the product.

Generic name: Cabozantinib S-Malate  ·  Brand name: Cabometyx.

See the full Cabozantinib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cabozantinib S-Malate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cabozantinib S-Malate.

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Pharmacist Counseling Corner

Cabozantinib S-Malate & Supplements: Common Questions

What supplements interact with Cabozantinib S-Malate?
In our interaction database, 138 supplement and herbal ingredients have an interaction with Cabozantinib S-Malate on file — 3 rated major, 94 moderate, and 41 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Cabozantinib S-Malate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Cabozantinib S-Malate?
That depends entirely on which supplement. The honest answer for Cabozantinib S-Malate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Cabometyx have the same supplement interactions as Cabozantinib S-Malate?
Yes — Cabometyx all contain Cabozantinib S-Malate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Cabozantinib S-Malate and my other medications?
This page covers Cabozantinib S-Malate against supplements and herbal ingredients. Checking Cabozantinib S-Malate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cabozantinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 7, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.