Water Avens + Hydroxyurea
Hydroxyurea brand names: Droxia, Hydrea, Siklos, Xromi.
We found no known interaction between Water Avens and Hydroxyurea in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Water Avens and Hydroxyurea
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Hydroxyurea and Water Avens in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Water Avens at all — not against Hydroxyurea, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Water Avens safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Questions About Water Avens or Hydroxyurea
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Water Avens or Hydroxyurea, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Hydroxyurea
This page covers Water Avens only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydroxyurea page lists 18 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 10 minor.
From our pharmacist’s overview on the Hydroxyurea page
“People take hydroxyurea (Droxia, Hydrea, Siklos, Xromi) for serious reasons, most often sickle cell disease or certain blood cancers, and it only works if a steady dose reaches the bloodstream. That is exactly what nearly all 18 supplements listed here can undermine, so this page earns real vigilance rather than a skim.”
Reviewed by 2 · Jul 18, 2026
Where Water Avens and Hydroxyurea Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#926 of 1,452 supplements looked up here in the last 7 days
#39 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Water Avens is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Water Avens reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Water Avens and Hydroxyurea records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Water Avens
What is Water Avens?
- Diarrhea and digestive upset
- Sore throat and mouth irritation
- Mild fever
- General tonic
- Astringent for minor wounds
Water avens is a traditional herb whose root has been used as an astringent for diarrhea, sore throats, and digestive complaints. There is very little modern scientific research to confirm that it works or to define a safe dose, so use it cautiously and talk with a pharmacist or doctor first.
Geum rivale · Rosaceae · Root and rhizome (occasionally aerial parts) · Dried root, tea/decoction, tincture
An interaction check asks whether these two react with each other — it does not ask whether Water Avens is a good idea for someone in your situation. Here is what our Water Avens record says about it on its own.
Water Avens: dosing
There is no established or standardized dose for water avens. Traditional use involved teas (decoctions) of the dried root or tinctures, but reliable, research-based dosing is not available.If you choose to use a product, follow the directions on the label and do not exceed them.
From our Water Avens monograph — the full record covers uses, side effects and every documented interaction.
About Hydroxyurea
What Is Hydroxyurea Used For?
Brand names: Droxia, Hydrea, Siklos, Xromi
Hydroxyurea is used for several serious conditions. Droxia, Siklos, and Xromi are each indicated to reduce the frequency of painful crises and reduce the need for blood transfusions in patients with sickle cell anemia who have recurrent moderate to severe painful crises. Siklos is approved for adults and children 2 years and older; Xromi is approved for children 6 months and older; Droxia is approved for adults.
Hydrea capsules and Hydroxyurea capsules are indicated for resistant chronic myeloid leukemia and for locally advanced squamous cell carcinomas of the head and neck (excluding the lip) when used together with chemoradiation.
Most-Reported Side Effects for Hydroxyurea
From FAERS, the FDA’s public side-effect reporting system (21,027 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Water Avens
Browse every other medication we’ve checked against Water Avens — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Water Avens against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Ibuprofen ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Water Avens list.
Water Avens References
The 2 sources that drive our Water Avens monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Water Avens is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
- Herbs and Supplements — MedlinePlus (U.S. National Library of Medicine) Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Water Avens and Hydroxyurea Together: Common Questions
Is it safe to take Water Avens with Hydroxyurea?
Does Hydroxyurea interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Hydroxyurea and Water Avens?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.