Watercress + Acetaminophen, Chlorzoxazone
Acetaminophen, Chlorzoxazone brand names: Parafon Forte, Extra Strength Tylenol Aches & Strains, Acetazone Forte.
Watercress has a moderate interaction with Acetaminophen, Chlorzoxazone. Watercress might reduce the metabolism of chlorzoxazone and increase its effects and side effects.
Read the full interaction reportWatercress and Acetaminophen, Chlorzoxazone
Here is the interaction we found between these two, with the evidence behind it.
CHLORZOXAZONE (Parafon Forte, Paraflex)
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's what's going on with this combo. Your medicine pairs acetaminophen with chlorzoxazone, a muscle relaxer. Watercress contains compounds that slow down the liver enzyme (CYP2E1) that normally clears chlorzoxazone. In a small human study, just 50 grams of watercress raised chlorzoxazone levels by about 56% and made it stick around longer. Chlorzoxazone is not a prodrug, so slowing its breakdown means more of it builds up in your body.
Practically, that could mean stronger drowsiness, dizziness, lightheadedness, or an upset stomach from the chlorzoxazone part. A normal serving of watercress in a salad probably isn't a big deal for most folks, but concentrated extracts are another story. If you use watercress supplements regularly, please check with your pharmacist or doctor first.
- Leclercq I, Desager JP, Horsmans Y. Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 1998;64:144-9. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Watercress Also Interacts With Other Medications
Watercress has 5 moderate known drug interactions in our database — the Acetaminophen, Chlorzoxazone one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Watercress
We haven’t checked that one against Watercress yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Watercress. Pick one to open its full report.
See Every Supplement That Interacts With Acetaminophen, Chlorzoxazone
This page covers Watercress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Chlorzoxazone page lists 162 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Procaine (major) and Siberian Cocklebur (major).
By severity: 6 major · 120 moderate · 36 minor.
Taking Watercress as Part of a Dietary Supplement Product? Check It for Interactions
We hold 820 real supplement products containing Watercress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Watercress. Your product may carry other ingredients that interact with Acetaminophen, Chlorzoxazone too, on top of Watercress — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Watercress and Acetaminophen, Chlorzoxazone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#280 of 1,452 supplements looked up here in the last 7 days
#608 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Watercress
What is Watercress?
- Source of vitamins and minerals
- Antioxidant support
- General nutrition
- Traditional cough and congestion remedy
- Skin and detox tonics
Watercress is a nutrient-rich leafy green that provides vitamins A, C, and K plus minerals and antioxidant plant compounds. Eaten as a food it is generally safe and healthy for most people, but strong human evidence for concentrated supplement health claims is limited. Talk to your pharmacist or doctor before using high-dose extracts, especially if you are pregnant, breastfeeding, or have a medical condition.
Other Drugs & Watercress
Browse every other medication we’ve checked against Watercress — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
5 interactions
No interaction 2,824 drugs checked — show the list
We also checked Watercress against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Acetaminophen ›
- Abemaciclib ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Amitriptyline ›
- Methotrexate ›
- Bupropion ›
- Isotretinoin ›
- Bendamustine ›
- Amlodipine Besylate ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,824 medications checked with no known interaction — see the full Watercress list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Acetaminophen, Chlorzoxazone Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Chlorzoxazone as a medicine that can lower these. This is not an interaction with Watercress — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Acetaminophen, Chlorzoxazone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Watercress and Acetaminophen, Chlorzoxazone Together: Common Questions
Can you take Watercress with Acetaminophen, Chlorzoxazone?
How serious is the Watercress and Acetaminophen, Chlorzoxazone interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.