Medication interaction hub

What Supplements Interact with Acetaminophen, Chlorzoxazone?

Acetaminophen, Chlorzoxazone brand names: Parafon Forte, Extra Strength Tylenol Aches & Strains, Acetazone Forte. Every interaction below applies to the brands too.

162 Interactions 6 Major 120 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 17, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Chlorzoxazone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Chlorzoxazone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

162 supplements and herbal ingredients have interactions with Acetaminophen, Chlorzoxazone on file in the HelloPharmacist interaction database — 6 rated major, 120 moderate, and 36 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer, Procaine and Wine.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Acetaminophen, Chlorzoxazone.

Major 6 Moderate 120 Minor 36 No known interaction 1,290

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Chlorzoxazone: Top Interactions at a Glance

The Acetaminophen, Chlorzoxazone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 162 interacting ingredients — plus 1,290 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Chlorzoxazone Combinations Today

The Acetaminophen, Chlorzoxazone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Magnesium + Acetaminophen, Chlorzoxazonei

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.

Read the full interaction Moderate Likelihood Possible Baikal Skullcap + Acetaminophen, Chlorzoxazonei

Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Read the full interaction Minor Likelihood Possible Licorice + Acetaminophen, Chlorzoxazonei

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Acetaminophen, Chlorzoxazonei

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Read the full interaction Minor Likelihood Possible Anise + Acetaminophen, Chlorzoxazonei

Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Acetaminophen, Chlorzoxazonei

Siberian cocklebur can adversely affect the kidney.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Chlorzoxazone

All 1,452 ingredients in our database, ranked by severity — 162 with a Acetaminophen, Chlorzoxazone interaction on file and 1,290 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Chlorzoxazone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Magnesium with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect...

Full Magnesium + Acetaminophen, Chlorzoxazone answer

Can you take Baikal Skullcap with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.

Full Baikal Skullcap + Acetaminophen, Chlorzoxazone answer

Can you take Licorice with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Full Licorice + Acetaminophen, Chlorzoxazone answer

Can you take Eucalyptus with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Full Eucalyptus + Acetaminophen, Chlorzoxazone answer

Can you take Anise with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, anise oil might decrease the levels and clinical effects of acetaminophen.

Full Anise + Acetaminophen, Chlorzoxazone answer

Can you take Valerian with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Acetaminophen, Chlorzoxazone answer

Can you take Vitamin A with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Acetaminophen, Chlorzoxazone answer

Can you take Wheatgrass with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Acetaminophen, Chlorzoxazone answer

Can you take Winter Cherry with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).

Full Winter Cherry + Acetaminophen, Chlorzoxazone answer

Can you take Zizyphus with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Acetaminophen, Chlorzoxazone answer

Can you take Green Tea with Acetaminophen, Chlorzoxazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Green Tea + Acetaminophen, Chlorzoxazone answer

Can you take Thyroid Extract with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Acetaminophen, Chlorzoxazone answer

Can you take Hibiscus Sabdariffa with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking Hibiscus sabdariffa with acetaminophen might decrease the clinical effects of acetaminophen.

Full Hibiscus Sabdariffa + Acetaminophen, Chlorzoxazone answer

Can you take Vitamin C with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Chlorzoxazone answer

Can you take Agar with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Acetaminophen, Chlorzoxazone answer

Can you take Algin with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Acetaminophen, Chlorzoxazone answer

Can you take Aloe with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Acetaminophen, Chlorzoxazone answer

Can you take Atractylodes with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, atractylodes might decrease the levels of CYP1A2 substrates.

Full Atractylodes + Acetaminophen, Chlorzoxazone answer

Can you take Bael with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Bael extract and its constituent marmesinin inhibited cytochrome P450 1A2 (CYP1A2) activity in vitro.

Full Bael + Acetaminophen, Chlorzoxazone answer

Can you take Beet with Acetaminophen, Chlorzoxazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.

Full Beet + Acetaminophen, Chlorzoxazone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Chlorzoxazone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Chlorzoxazone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Chlorzoxazone sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Chlorzoxazone (Parafon Forte, Paraflex) 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Skeletal Muscle Relaxants 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Acetaminophen, Chlorzoxazone through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorzoxazone through this category.

Related: does Acetaminophen, Chlorzoxazone deplete any nutrients?

Acetaminophen, Chlorzoxazone has 3 reported nutrient associations in the research literature — see the Acetaminophen, Chlorzoxazone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Chlorzoxazone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Chlorzoxazone.

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Products that contain Acetaminophen, Chlorzoxazone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Acetaminophen, Chlorzoxazone.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur DNA Evolve by Complete Ascentials contains Procaine DNA Evolve by Complete Ascentials contains Procaine
Pharmacist Counseling Corner

Acetaminophen, Chlorzoxazone & Supplements: Common Questions

What supplements interact with Acetaminophen, Chlorzoxazone?
In our interaction database, 162 supplement and herbal ingredients have an interaction with Acetaminophen, Chlorzoxazone on file — 6 rated major, 120 moderate, and 36 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Acetaminophen, Chlorzoxazone supplement interactions are the most serious?
The 6 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Procaine and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Chlorzoxazone?
That depends entirely on which supplement. The honest answer for Acetaminophen, Chlorzoxazone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Parafon Forte have the same supplement interactions as Acetaminophen, Chlorzoxazone?
Yes — Parafon Forte, Extra Strength Tylenol Aches & Strains, Acetazone Forte all contain Acetaminophen, Chlorzoxazone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Chlorzoxazone deplete any vitamins or nutrients?
It might — Acetaminophen, Chlorzoxazone has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Chlorzoxazone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Chlorzoxazone and my other medications?
This page covers Acetaminophen, Chlorzoxazone against supplements and herbal ingredients. Checking Acetaminophen, Chlorzoxazone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 17, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.