Medication interaction hub

What Supplements Interact with Riluzole?

Riluzole brand names: Rilutek, Tiglutik, Exservan. Every interaction below applies to the brands too.

141 Interactions 4 Major 106 Moderate 31 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Riluzole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Riluzole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Riluzole (Rilutek, Tiglutik, Exservan) slows the progression of ALS, and it already works the liver hard, which is where this list turns genuinely serious. The four major-rated entries among 141 documented interactions cluster around two hazards: extra liver strain (Siberian cocklebur has caused liver failure, and heavy alcohol from beer or wine adds similar risk) and blocked absorption, since activated charcoal can pull the drug out of the body before it does its job.

The remaining 106 moderate and 31 minor entries mostly work more quietly. Riluzole is cleared by a liver enzyme called CYP1A2, and roughly 80 ingredients here can speed that enzyme up or slow it down, changing how much drug stays in your blood, while another 38 carry their own liver-toxicity concerns. Riluzole treatment already includes routine liver tests, so name every supplement you take to whoever orders them; herbal liver stress looks identical to drug-related trouble on a lab slip.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 106 Minor 31 No known interaction 1,311

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Riluzole: Top Interactions at a Glance

The Riluzole supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 141 interacting ingredients — plus 1,311 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Riluzole Combinations Today

The Riluzole + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Gymnema + Riluzolei

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Possible Catechu + Riluzolei

Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Guarana + Riluzolei

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.

Read the full interaction Minor Likelihood Possible Licorice + Riluzolei

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Minor Likelihood Possible Yohimbe + Riluzolei

Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Boldo + Riluzolei

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Read the full interaction
The complete list

Every Supplement Checked Against Riluzole

All 1,452 ingredients in our database, ranked by severity — 141 with a Riluzole interaction on file and 1,311 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Riluzole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Gymnema with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + Riluzole answer

Can you take Catechu with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.

Full Catechu + Riluzole answer

Can you take Guarana with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.

Full Guarana + Riluzole answer

Can you take Licorice with Riluzole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Full Licorice + Riluzole answer

Can you take Yohimbe with Riluzole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Yohimbe + Riluzole answer

Can you take Black Cohosh with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Riluzole answer

Can you take Black Hoof Mushroom with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Full Black Hoof Mushroom + Riluzole answer

Can you take Black Tea with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.

Full Black Tea + Riluzole answer

Can you take Boldo with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Riluzole answer

Can you take Boswellia Serrata with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.

Full Boswellia Serrata + Riluzole answer

Can you take Broccoli with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.

Full Broccoli + Riluzole answer

Can you take Brussels Sprout with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Full Brussels Sprout + Riluzole answer

Can you take Buchu with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Riluzole answer

Can you take Bulbine Natalensis with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP1A2 substrates.

Full Bulbine Natalensis + Riluzole answer

Can you take Cabbage with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cabbage might decrease levels of drugs metabolized by CYP1A2.

Full Cabbage + Riluzole answer

Can you take Caffeine with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.

Full Caffeine + Riluzole answer

Can you take Camphor with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Riluzole answer

Can you take Cassia Cinnamon with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Riluzole answer

Can you take Cauliflower with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabba...

Full Cauliflower + Riluzole answer

Can you take Celery with Riluzole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery might increase levels of drugs metabolized by CYP1A2.

Full Celery + Riluzole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Riluzole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Riluzole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Riluzole sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Riluzole through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Riluzole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Riluzole through this category.

Riluzole (Rilutek) 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Riluzole through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Riluzole through this category.

About Riluzole

Riluzole is an oral medication used to treat amyotrophic lateral sclerosis (ALS), available in tablet, dissolving oral film, and oral suspension forms.

Generic name: Riluzole  ·  Brand names: Rilutek, Tiglutik, Exservan.

See the full Riluzole drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Riluzole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Riluzole.

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Products that contain Riluzole-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Riluzole.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Riluzole & Supplements: Common Questions

What supplements interact with Riluzole?
More than you might expect — 141 in total, though they are far from equal: 4 are rated major, 106 moderate, and 31 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Riluzole supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Activated Charcoal, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Riluzole?
Usually yes — most people on Riluzole can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Rilutek have the same supplement interactions as Riluzole?
Yes — Rilutek, Tiglutik, Exservan all contain Riluzole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Riluzole and my other medications?
This page covers Riluzole against supplements and herbal ingredients. Checking Riluzole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Riluzole drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.