Riluzole

Generic name: Pronounced as (ril' yoo zole)
Brand names
  • Rilutek®
  • Tiglutik®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 03/15/2019

Riluzole is used to treat amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease). Riluzole is in a class of medications called benzothiazoles. It works by changing the activity of certain natural substances in the body that affect nerves and muscles.

Riluzole comes as a tablet and a suspension (liquid) to take by mouth. It usually is taken on an empty stomach (1 hour before or 2 hours after meals) twice a day, every 12 hours. You should take it at the same times each day (usually in the morning and in the evening). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take riluzole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well (at least 30 seconds) before each use to mix the medication evenly. Be sure to turn the bottle up and down until you do not see clear liquid at the top or any particles at the bottom of the bottle. Read the instructions for use before you start taking riluzole suspension. Be sure that you understand these directions, and ask your pharmacist if you have any questions.

Riluzole may slow progression of ALS but does not cure it. Continue to take riluzole even if you feel well. Do not stop taking riluzole without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking riluzole,

  • tell your doctor and pharmacist if you are allergic to riluzole, any other medications, or any of the ingredients in riluzole tablets or suspension. Ask your pharmacist for a list of the ingredients..

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: allopurinol (Aloprim, Lopurin, Zyloprim), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), ciprofloxacin (Cipro), fluvoxamine (Luvox), methoxsalen (8-MOP, Oxsoralen), methyldopa (in Aldochlor), mexiletine, oral contraceptives (birth control pills), rifampin (Rifadin, in Rifamate, in Rifater), sulfasalazine (Azulfidine), vemurafenib (Zelboraf), and zileuton (Zyflo).

  • tell your doctor if you are of Japanese descent and if you have or have ever had kidney or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking riluzole, call your doctor.

  • tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.

Avoid eating charcoal-broiled foods.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Riluzole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weakness

    • dizziness

    • dry mouth

    • mouth numbness

    • difficulty falling asleep or staying asleep

    • drowsiness

    • swelling of the hands, feet, ankles, or lower legs

    • fast heart rate

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • hives

    • rash

    • itching

    • difficulty breathing or swallowing

    • dry cough

    • nausea

    • stomach pain

    • vomiting

    • extreme tiredness

    • unusual bleeding or bruising

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • dark urine

    • fever, chills, cough, or other signs of infection

    • muscle or joint pain

    • headache

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from light and excess heat and moisture (not in the bathroom). Do not freeze the suspension. Be sure to store the suspension bottle upright. Be sure to use the suspension within 15 days of opening the bottle and discard any remaining medication after 15 days.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • memory loss

  • bluish coloring of the skin, headache, tiredness, shortness of breath, lack of energy

  • hard to concentrate, involuntary movements, seizures

  • coma

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to riluzole.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Riluzole can be decreased when combined with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Riluzole can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The serum concentration of Riluzole can be decreased when it is combined with Leflunomide.
Nevirapine Nevirapine The metabolism of Riluzole can be decreased when combined with Nevirapine.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Riluzole is combined with Dolasetron.
Aminophylline Aminophylline Riluzole may increase the excretion rate of Aminophylline which could result in a lower serum level and potentially a reduction in efficacy.
Anagrelide Anagrelide The metabolism of Riluzole can be decreased when combined with Anagrelide.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Riluzole.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Riluzole.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Riluzole is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) The metabolism of Riluzole can be decreased when combined with Conjugated estrogens.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Riluzole is combined with Guanfacine.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Riluzole is combined with Naratriptan.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Riluzole.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Riluzole.
Ranitidine Ranitidine The metabolism of Ranitidine can be decreased when combined with Riluzole.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Riluzole.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Riluzole is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Riluzole.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Riluzole.
Zolmitriptan Zolmitriptan The metabolism of Riluzole can be decreased when combined with Zolmitriptan.
Famotidine Injection Famotidine Injection The metabolism of Riluzole can be decreased when combined with Famotidine.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Riluzole.
Interferon Beta-1b Injection Interferon Beta-1b Injection The metabolism of Riluzole can be decreased when combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The metabolism of Riluzole can be decreased when combined with Interferon gamma-1b.
Levofloxacin Injection Levofloxacin Injection The metabolism of Riluzole can be decreased when combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Riluzole can be increased when combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Riluzole is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The therapeutic efficacy of Riluzole can be decreased when used in combination with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Riluzole.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Riluzole.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Riluzole which could result in a higher serum level.
Ondansetron Ondansetron The metabolism of Riluzole can be decreased when combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Riluzole is combined with Granisetron.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Riluzole.
Alosetron Alosetron The metabolism of Riluzole can be decreased when combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Riluzole.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Riluzole can be decreased when used in combination with Hydroxychloroquine.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Riluzole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Riluzole is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Riluzole which could result in a higher serum level.
Telmisartan Telmisartan Telmisartan may decrease the excretion rate of Riluzole which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Riluzole is combined with Zaleplon.
Anakinra Anakinra The metabolism of Riluzole can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Riluzole is combined with Desloratadine.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Riluzole.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Trimipramine is combined with Riluzole.
Etanercept Injection Etanercept Injection The metabolism of Riluzole can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Riluzole may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Riluzole can be increased when combined with Modafinil.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Riluzole is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Riluzole is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Riluzole can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Riluzole is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Riluzole.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Riluzole is combined with Dexmethylphenidate.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Riluzole is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Riluzole.
Mefloquine Mefloquine The therapeutic efficacy of Riluzole can be decreased when used in combination with Mefloquine.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Riluzole can be decreased when combined with Interferon beta-1a.
Tegaserod Tegaserod The metabolism of Riluzole can be decreased when combined with Tegaserod.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Riluzole.
Gemifloxacin Gemifloxacin The metabolism of Riluzole can be decreased when combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Riluzole can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Riluzole.
Infliximab Injection Infliximab Injection The metabolism of Riluzole can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Riluzole.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Riluzole is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Norethisterone can be increased when combined with Riluzole.
Trospium Trospium Riluzole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Riluzole.
Erlotinib Erlotinib Erlotinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Riluzole is combined with Eszopiclone.
Ganciclovir Ganciclovir The therapeutic efficacy of Riluzole can be decreased when used in combination with Ganciclovir.
Solifenacin Solifenacin Riluzole may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir The therapeutic efficacy of Riluzole can be decreased when used in combination with Valganciclovir.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Riluzole.
Entecavir Entecavir The metabolism of Riluzole can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The metabolism of Riluzole can be decreased when combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Riluzole can be increased when it is combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Riluzole is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Riluzole is combined with Ramelteon.
Darifenacin Darifenacin Riluzole may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Riluzole is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Riluzole can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Riluzole can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Riluzole can be increased when combined with Phenylephrine.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Riluzole is combined with Felbamate.
Abatacept Injection Abatacept Injection The metabolism of Riluzole can be increased when combined with Abatacept.
Rasagiline Rasagiline The metabolism of Rasagiline can be decreased when combined with Riluzole.
Imatinib Imatinib Imatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Gefitinib Gefitinib Gefitinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Riluzole is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Riluzole can be decreased when combined with Bortezomib.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Riluzole can be increased when combined with Insulin glulisine.
Primaquine Primaquine The metabolism of Riluzole can be decreased when combined with Primaquine.
Pemetrexed Injection Pemetrexed Injection The metabolism of Riluzole can be decreased when combined with Pemetrexed.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Riluzole is combined with Dimenhydrinate.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Sorafenib Sorafenib Sorafenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Sunitinib Sunitinib Sunitinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Riluzole is combined with Levocetirizine.
Dasatinib Dasatinib Dasatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Mexiletine Mexiletine The metabolism of Riluzole can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Riluzole can be increased when combined with Armodafinil.
Nilotinib Nilotinib Nilotinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Riluzole.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Riluzole.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Riluzole is combined with Desvenlafaxine.
Bendamustine Injection Bendamustine Injection The metabolism of Bendamustine can be decreased when combined with Riluzole.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Riluzole.
Certolizumab Injection Certolizumab Injection The metabolism of Riluzole can be increased when combined with Certolizumab pegol.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Riluzole.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Riluzole.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Riluzole.
Eltrombopag Eltrombopag Eltrombopag may decrease the excretion rate of Riluzole which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Riluzole is combined with Milnacipran.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Riluzole can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol The metabolism of Riluzole can be decreased when combined with Betaxolol.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Riluzole is combined with Iloperidone.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Riluzole is combined with Lacosamide.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Riluzole.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Riluzole.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Topotecan Topotecan Riluzole may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Riluzole can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Riluzole.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Riluzole is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Riluzole is combined with Vigabatrin.
Albendazole Albendazole The metabolism of Riluzole can be decreased when combined with Albendazole.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Riluzole.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Riluzole.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Riluzole is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Riluzole can be increased when combined with Tocilizumab.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Riluzole.
Cabazitaxel Injection Cabazitaxel Injection Cabazitaxel may decrease the excretion rate of Riluzole which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Riluzole is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The metabolism of Riluzole can be decreased when combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Riluzole is combined with Vilazodone.
Rilpivirine Rilpivirine Rilpivirine may decrease the excretion rate of Riluzole which could result in a higher serum level.
Telaprevir Telaprevir Glecaprevir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Abiraterone Abiraterone The serum concentration of Riluzole can be increased when it is combined with Abiraterone.
Vandetanib Vandetanib Vandetanib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Riluzole.
Vemurafenib Vemurafenib The serum concentration of Riluzole can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib Vismodegib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Riluzole.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Riluzole.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Riluzole is combined with Tiagabine.
Regorafenib Regorafenib Regorafenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Teriflunomide Teriflunomide The serum concentration of Riluzole can be decreased when it is combined with Teriflunomide.
Ponatinib Ponatinib Ponatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Riluzole is combined with Pomalidomide.
Dabrafenib Dabrafenib Dabrafenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Afatinib Afatinib Afatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Riluzole is combined with Levomilnacipran.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Riluzole is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Simeprevir Simeprevir Simeprevir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Riluzole can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Riluzole can be increased when combined with Apremilast.
Siltuximab Injection Siltuximab Injection The metabolism of Riluzole can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Riluzole is combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The metabolism of Riluzole can be increased when combined with Belinostat.
Hydrocodone Hydrocodone Riluzole may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Riluzole may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The metabolism of Riluzole can be decreased when combined with Peginterferon beta-1a.
Olaparib Olaparib Olaparib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Riluzole is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Riluzole is combined with Tasimelteon.
Pirfenidone Pirfenidone The metabolism of Pirfenidone can be decreased when combined with Riluzole.
Secukinumab Injection Secukinumab Injection The metabolism of Riluzole can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Riluzole.
Palbociclib Palbociclib Palbociclib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Riluzole can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The metabolism of Riluzole can be decreased when combined with Lenvatinib.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Riluzole.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Riluzole is combined with Flibanserin.
Rolapitant Rolapitant Rolapitant may decrease the excretion rate of Riluzole which could result in a higher serum level.
Daclatasvir Daclatasvir Daclatasvir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Riluzole is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Riluzole.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Riluzole is combined with Cariprazine.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Riluzole can be increased when combined with Insulin degludec.
Osimertinib Osimertinib The serum concentration of Riluzole can be decreased when it is combined with Osimertinib.
Alectinib Alectinib Alectinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The therapeutic efficacy of Riluzole can be decreased when used in combination with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may decrease the excretion rate of Riluzole which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Riluzole is combined with Brivaracetam.
Venetoclax Venetoclax Venetoclax may decrease the excretion rate of Riluzole which could result in a higher serum level.
Cobicistat Cobicistat Cobicistat may decrease the excretion rate of Riluzole which could result in a higher serum level.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Riluzole is combined with Pimavanserin.
Obeticholic Acid Obeticholic Acid The metabolism of Riluzole can be decreased when combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Riluzole is combined with Diphenhydramine.
Rucaparib Rucaparib Rucaparib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Brigatinib Brigatinib Brigatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Riluzole may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Safinamide Safinamide Safinamide may decrease the excretion rate of Riluzole which could result in a higher serum level.
Midostaurin Midostaurin The metabolism of Riluzole can be decreased when combined with Midostaurin.
Enasidenib Enasidenib Enasidenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Abemaciclib Abemaciclib Abemaciclib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Letermovir Letermovir Letermovir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection Riluzole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide Apalutamide may increase the excretion rate of Riluzole which could result in a lower serum level and potentially a reduction in efficacy.
Fostamatinib Fostamatinib Fostamatinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Avatrombopag Avatrombopag Avatrombopag may decrease the excretion rate of Riluzole which could result in a higher serum level.
Baricitinib Baricitinib Baricitinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Riluzole can be increased when used in combination with Lofexidine.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Riluzole.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Riluzole.
Dacomitinib Dacomitinib Dacomitinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Riluzole is combined with Stiripentol.
Gilteritinib Gilteritinib Gilteritinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Glasdegib Glasdegib Glasdegib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Rifamycin Rifamycin The metabolism of Riluzole can be decreased when combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Riluzole can be increased when combined with Emapalumab.
Acyclovir Ophthalmic Acyclovir Ophthalmic The metabolism of Acyclovir can be decreased when combined with Riluzole.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Riluzole is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Riluzole is combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Riluzole can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Riluzole can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Riluzole.
Pitolisant Pitolisant The metabolism of Riluzole can be increased when combined with Pitolisant.
Fedratinib Fedratinib Fedratinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Riluzole.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Riluzole is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Riluzole is combined with Lumateperone.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Riluzole.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Riluzole.
Ripretinib Ripretinib Ripretinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Capmatinib Capmatinib The serum concentration of Riluzole can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Riluzole is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Riluzole.
Fostemsavir Fostemsavir Fostemsavir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Pralsetinib Pralsetinib Pralsetinib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Riluzole can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Riluzole.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Riluzole is combined with Viloxazine.
Theophylline Theophylline Riluzole may increase the excretion rate of Theophylline which could result in a lower serum level and potentially a reduction in efficacy.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Riluzole.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Riluzole is combined with Trazodone.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Riluzole is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Riluzole.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Riluzole is combined with Levorphanol.
Primidone Primidone The metabolism of Riluzole can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Riluzole is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Riluzole is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Riluzole.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Riluzole is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Riluzole is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Riluzole.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Riluzole.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Riluzole.
Carmustine Carmustine The metabolism of Riluzole can be decreased when combined with Carmustine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Riluzole.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Riluzole.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Riluzole.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Riluzole is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Riluzole can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Riluzole is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Riluzole is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Riluzole is combined with Ergoloid mesylate.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Riluzole.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Riluzole.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Riluzole is combined with Trifluoperazine.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Riluzole.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Riluzole.
Oxybutynin Oxybutynin Riluzole may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Riluzole may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Trihexyphenidyl Trihexyphenidyl Riluzole may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Riluzole is combined with Perphenazine.
Azathioprine Azathioprine The metabolism of Azathioprine can be decreased when combined with Riluzole.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Riluzole.
Methylphenidate Methylphenidate The therapeutic efficacy of Riluzole can be decreased when used in combination with Methylphenidate.
Amoxapine Amoxapine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Riluzole which could result in a higher serum level.
Carbamazepine Carbamazepine Carbamazepine may increase the Change in thyroid function activities of Riluzole.
Molindone Molindone The risk or severity of adverse effects can be increased when Riluzole is combined with Molindone.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Riluzole.
Cimetidine Cimetidine The metabolism of Riluzole can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Riluzole can be decreased when combined with Warfarin.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Riluzole is combined with Clonazepam.
Promethazine Promethazine The risk or severity of adverse effects can be increased when Riluzole is combined with Promethazine.
Griseofulvin Griseofulvin The metabolism of Riluzole can be increased when combined with Griseofulvin.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Riluzole.
Chloroquine Chloroquine The therapeutic efficacy of Riluzole can be decreased when used in combination with Chloroquine.
Quinine Quinine The risk or severity of adverse effects can be increased when Quinine is combined with Riluzole.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Riluzole.
Triamterene Triamterene The metabolism of Riluzole can be decreased when combined with Triamterene.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Riluzole.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Riluzole.
Desipramine Desipramine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline Amitriptyline Riluzole may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine Imipramine The metabolism of Riluzole can be decreased when combined with Imipramine.
Quinidine Quinidine The metabolism of Riluzole can be decreased when combined with Quinidine.
Isoniazid Isoniazid The metabolism of Riluzole can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Riluzole can be increased when combined with Rifampicin.
Disopyramide Disopyramide The metabolism of Riluzole can be decreased when combined with Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Riluzole.
Tamoxifen Tamoxifen The metabolism of Riluzole can be decreased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Riluzole.
Methimazole Methimazole The metabolism of Riluzole can be decreased when combined with Methimazole.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Riluzole.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Riluzole is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Riluzole.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Cyproheptadine Cyproheptadine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Riluzole.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Riluzole is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Riluzole.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Riluzole.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Riluzole is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Riluzole.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Riluzole.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Riluzole.
Disulfiram Disulfiram The therapeutic efficacy of Riluzole can be decreased when used in combination with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Riluzole can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline Riluzole may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Amphotericin B Injection Amphotericin B Injection The therapeutic efficacy of Riluzole can be decreased when used in combination with Amphotericin B.
Mercaptopurine Mercaptopurine Riluzole may increase the excretion rate of Mercaptopurine which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Riluzole.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Riluzole is combined with Nalbuphine.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Riluzole.
Flavoxate Flavoxate Riluzole may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Fluorouracil Injection Fluorouracil Injection The metabolism of Riluzole can be decreased when combined with Fluorouracil.
Dacarbazine Dacarbazine The metabolism of Dacarbazine can be decreased when combined with Riluzole.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Riluzole is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Riluzole can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The metabolism of Riluzole can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Riluzole is combined with Pyrantel.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Riluzole.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Riluzole is combined with Thiothixene.
Chlorambucil Chlorambucil The therapeutic efficacy of Riluzole can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Riluzole.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Riluzole.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Riluzole is combined with Triazolam.
Dicyclomine Dicyclomine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Riluzole may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Nifedipine Nifedipine The metabolism of Riluzole can be decreased when combined with Nifedipine.
Verapamil Verapamil The metabolism of Riluzole can be decreased when combined with Verapamil.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Riluzole is combined with Pindolol.
Streptozocin Streptozocin The metabolism of Riluzole can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Riluzole.
Nafcillin Injection Nafcillin Injection The metabolism of Riluzole can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline Riluzole may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil Gemfibrozil The metabolism of Riluzole can be decreased when combined with Gemfibrozil.
Guanabenz Guanabenz The metabolism of Riluzole can be decreased when combined with Guanabenz.
Pimozide Pimozide The risk or severity of adverse effects can be increased when Riluzole is combined with Pimozide.
Amiodarone Amiodarone The metabolism of Riluzole can be decreased when combined with Amiodarone.
Ciprofloxacin Ciprofloxacin The metabolism of Riluzole can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Riluzole can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The metabolism of Riluzole can be decreased when combined with Interferon alfa-2b.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Riluzole.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Riluzole is combined with Estazolam.
Ofloxacin Ofloxacin The metabolism of Riluzole can be decreased when combined with Ofloxacin.
Nabumetone Nabumetone The metabolism of Riluzole can be decreased when combined with Nabumetone.
Pravastatin Pravastatin Pravastatin may decrease the excretion rate of Riluzole which could result in a higher serum level.
Zolpidem Zolpidem Riluzole may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Omeprazole Omeprazole Omeprazole may decrease the excretion rate of Riluzole which could result in a higher serum level.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Riluzole.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Riluzole is combined with Gabapentin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Riluzole.
Fluvoxamine Fluvoxamine The metabolism of Riluzole can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Riluzole is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Riluzole.
Tramadol Tramadol The risk or severity of CNS depression can be increased when Riluzole is combined with Tramadol.
Lansoprazole Lansoprazole Lansoprazole may decrease the excretion rate of Riluzole which could result in a higher serum level.
Nicardipine Nicardipine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Riluzole is combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Riluzole can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir Saquinavir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Ritonavir Ritonavir Ritonavir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Riluzole.
Zafirlukast Zafirlukast The metabolism of Riluzole can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Riluzole.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Riluzole.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Riluzole can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Riluzole may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Riluzole is combined with Donepezil.
Nelfinavir Nelfinavir Nelfinavir may decrease the excretion rate of Riluzole which could result in a higher serum level.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Riluzole.
Flutamide Flutamide The metabolism of Riluzole can be decreased when combined with Flutamide.
Selegiline Selegiline The metabolism of Riluzole can be decreased when combined with Selegiline.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Riluzole is combined with Sertraline.
Propafenone Propafenone The metabolism of Riluzole can be decreased when combined with Propafenone.
Ropinirole Ropinirole Riluzole may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine The risk or severity of adverse effects can be increased when Riluzole is combined with Quetiapine.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Riluzole.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Riluzole is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Riluzole.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Riluzole is combined with Citalopram.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Riluzole.
Rosiglitazone Rosiglitazone The metabolism of Riluzole can be decreased when combined with Rosiglitazone.
Tolterodine Tolterodine Riluzole may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Riluzole may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Riluzole is combined with Levetiracetam.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Riluzole which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Riluzole.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists