Medication interaction hub

What Supplements Interact with Tacrine?

Tacrine brand name: Cognex. Every interaction below applies to the brands too.

156 Interactions 4 Major 118 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tacrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tacrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

156 supplements and herbal ingredients have interactions with Tacrine on file in the HelloPharmacist interaction database — 4 rated major, 118 moderate, and 34 minor. The most serious involve Siberian Cocklebur, Activated Charcoal, Beer and Wine.

Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Tacrine.

Major 4 Moderate 118 Minor 34 No known interaction 1,296

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tacrine: Top Interactions at a Glance

The Tacrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 156 interacting ingredients — plus 1,296 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tacrine Combinations Today

The Tacrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Ginger + Tacrinei

Theoretically, ginger might increase the levels of CYP1A2 substrates.

Read the full interaction Minor Likelihood Possible German Chamomile + Tacrinei

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.

Read the full interaction Minor Likelihood Possible Licorice + Tacrinei

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Ephedra + Tacrinei

Theoretically, ephedra might decrease levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Unlikely Turpentine Oil + Tacrinei

There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downregulation of CYP act...

Read the full interaction Moderate Likelihood Possible Cauliflower + Tacrinei

Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabbage, can increase cyt...

Read the full interaction
The complete list

Every Supplement Checked Against Tacrine

All 1,452 ingredients in our database, ranked by severity — 156 with a Tacrine interaction on file and 1,296 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tacrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Tacrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ginger might increase the levels of CYP1A2 substrates.

Full Ginger + Tacrine answer

Can you take German Chamomile with Tacrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.

Full German Chamomile + Tacrine answer

Can you take Licorice with Tacrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.

Full Licorice + Tacrine answer

Can you take Ephedra with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ephedra might decrease levels of drugs metabolized by CYP1A2.

Full Ephedra + Tacrine answer

Can you take Turpentine Oil with Tacrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. There is some concern that turpentine oil can inhibit CYP1A2 enzyme activity by up to 90% via induction of inflammation and subsequent downr...

Full Turpentine Oil + Tacrine answer

Can you take Cauliflower with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical evidence suggests that eating cruciferous vegetables, including broccoli, cauliflower, daikon radish sprouts, and cabba...

Full Cauliflower + Tacrine answer

Can you take Celery with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery might increase levels of drugs metabolized by CYP1A2.

Full Celery + Tacrine answer

Can you take Ceylon Leadwort with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.

Full Ceylon Leadwort + Tacrine answer

Can you take Chanca Piedra with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.

Full Chanca Piedra + Tacrine answer

Can you take Chaparral with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Tacrine answer

Can you take Clove with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.

Full Clove + Tacrine answer

Can you take Clubmoss with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that clubmoss extract can inhibit acetylcholinesterase activity.

Full Clubmoss + Tacrine answer

Can you take Cocoa with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Cocoa + Tacrine answer

Can you take Cola Nut with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Tacrine answer

Can you take Comfrey with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Tacrine answer

Can you take Dandelion with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Tacrine answer

Can you take Danshen with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, danshen may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Danshen + Tacrine answer

Can you take Dimethylsulfoxide (dmso) with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of cholinergic adverse effects when taken with cholinergic drugs.

Full Dimethylsulfoxide (dmso) + Tacrine answer

Can you take Echinacea with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.

Full Echinacea + Tacrine answer

Can you take Eleuthero with Tacrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Full Eleuthero + Tacrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tacrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tacrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tacrine sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Tacrine through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Tacrine through this category.

Cholinergic Drugs 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Tacrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tacrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Tacrine through this category.

Acetylcholinesterase (Ache) Inhibitors 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Tacrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Tacrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tacrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tacrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Tacrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Tacrine.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Tacrine & Supplements: Common Questions

What supplements interact with Tacrine?
In our interaction database, 156 supplement and herbal ingredients have an interaction with Tacrine on file — 4 rated major, 118 moderate, and 34 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Tacrine supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Tacrine?
That depends entirely on which supplement. The honest answer for Tacrine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Cognex have the same supplement interactions as Tacrine?
Yes — Cognex all contain Tacrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tacrine and my other medications?
This page covers Tacrine against supplements and herbal ingredients. Checking Tacrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.