Drug & supplement interaction

Mangosteen + Riluzole

Riluzole brand names: Rilutek, Tiglutik, Exservan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Mangosteen and Riluzole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mangosteen and Riluzole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Riluzole and Mangosteen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mangosteen safety at a glance

Mangosteen overall Use caution Generally considered safe as a food, but long-term safety of concentrated supplements is not well studied.
Pregnancy Avoid Not enough safety information; avoid supplement amounts during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid supplement amounts while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Riluzole and Mangosteen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Riluzole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Riluzole is filed under 5 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, hepatotoxic drugs. Mangosteen has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and donepezil (aricept) (minor) — and none of Riluzole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Mangosteen Does Interact With Other Medications

Mangosteen has 122 moderate, 3 minor known drug interactions in our database — Riluzole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 Minor 3 No known interaction 2,705 (incl. Riluzole)
Taking anything else?

Check Another of Your Medications Against Mangosteen

Covers the 2,830 medications we’ve checked against Mangosteen. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Mangosteen and Riluzole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Constipation / Vomiting / Nausea Additional detail

    Mangosteen

    “Orally, mangosteen extract up to 560 mg daily has been reported to cause constipation, abnormal stool, abdominal discomfort, abdominal bloating, salivation, nausea and vomiting, and diarrhea. It is not known if these side effects were related to mangosteen.”

    Mangosteen · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 97877. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed

    Riluzole

    Listed in the ADVERSE REACTIONS section of the FDA label for Riluzole. Read the label on DailyMed ›

  • Cough Additional detail

    Mangosteen

    “Orally, mangosteen extract up to 560 mg daily has been reported to cause dry throat, flu-like symptoms, cough, and nasal congestion. It is not known if these side effects were related to mangosteen.”

    Mangosteen · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 97877. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed

    Riluzole

    Listed in the ADVERSE REACTIONS section of the FDA label for Riluzole. Read the label on DailyMed ›

  • Tiredness / Dizziness Additional detail

    Mangosteen

    “Orally, mangosteen extract up to 560 mg daily has been reported to cause mild tiredness, headache, dizziness, and malaise. It is not known if these side effects were related to mangosteen.”

    Mangosteen · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 97877. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed

    Riluzole

    Listed in the ADVERSE REACTIONS section of the FDA label for Riluzole. Read the label on DailyMed ›

Reported for Mangosteen but not commonly for Riluzole: kidney problems, stomach upset, a stuffy or runny nose and weight loss.

Effects for Riluzole come from the ADVERSE REACTIONS section of its FDA label; effects for Mangosteen come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Riluzole

This page covers Mangosteen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Riluzole page lists 141 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Adrafinil (moderate).

By severity: 4 major · 106 moderate · 31 minor.

From our pharmacist’s overview on the Riluzole page

“Riluzole (Rilutek, Tiglutik, Exservan) slows the progression of ALS, and it already works the liver hard, which is where this list turns genuinely serious. The four major-rated entries among 141 documented interactions cluster around two hazards: extra liver strain (Siberian cocklebur has caused liver failure, and heavy alcohol from be…”

Reviewed by 2 · Jul 18, 2026

Open the Riluzole interaction page

One more smart check

Taking Mangosteen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,201 real supplement products containing Mangosteen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mangosteen. Even though Mangosteen itself has no known interaction with Riluzole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mangosteen and Riluzole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mangosteen
Top 25%

#258 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Riluzole
Steady interest

#1,648 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mangosteen reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Mangosteen and Riluzole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mangosteen

What is Mangosteen?

Mangosteen
  • Antioxidant support
  • Anti-inflammatory support
  • Immune support
  • Skin health
  • General wellness

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support, and general wellness, strong human evidence for these benefits is limited. It is likely fine as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Garcinia mangostana · Clusiaceae · Fruit, and especially the rind (pericarp) · Juice, capsules, tablets, powders, dried rind, extracts

An interaction check asks whether these two react with each other — it does not ask whether Mangosteen is a good idea for someone in your situation. Here is what our Mangosteen record says about it on its own.

Mangosteen: dosing

There is no standard, well-established dose for mangosteen supplements. Products vary widely in strength and form, from juices to capsules to powders.The best advice is to follow the directions on the product label and not exceed the recommended amount.

From our Mangosteen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mangosteen monograph & all interactions
Medication

About Riluzole

What Is Riluzole Used For?

Brand names: Rilutek, Tiglutik, Exservan

Riluzole is approved to treat amyotrophic lateral sclerosis (ALS) — the progressive neurological disease also known as Lou Gehrig's disease. This indication is shared across all available riluzole products, including tablets (Rilutek, riluzole), the dissolving oral film (Exservan), and the oral suspension (Tiglutik).

Tiglutik oral suspension is notable in that it can also be given through a PEG-tube (percutaneous endoscopic gastrostomy tube) for patients who have difficulty swallowing.

See full Riluzole drug information
Keep checking

Other Drugs & Mangosteen

Browse every other medication we’ve checked against Mangosteen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
3Minor
2,704No known interaction
122 Moderate 3 Minor 2,704 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Mangosteen page.

Minor

3 interactions

No interaction 2,704 drugs checked — show the list

We also checked Mangosteen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,704 medications checked with no known interaction — see the full Mangosteen list.

See the full Mangosteen interactions page
See every supplement checked against Riluzole, ranked by severity
Evidence & sources

Mangosteen References

The 6 references that drive our Mangosteen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Wong LP, Klemmer PJ. Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana. Am J Kidney Dis 2008;51:829-33. PubMed
  3. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  4. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998
  5. Suthammarak W, Numpraphrut P, Charoensakdi R, et al. Antioxidant-enhancing property of the polar fraction of mangosteen pericarp extract and evaluation of its safety in humans. Oxid Med Cell Longev 2016;2016:1293036. PubMed
  6. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mangosteen and Riluzole Together: Common Questions

Is it safe to take Mangosteen with Riluzole?
We do not list a known interaction between Mangosteen and Riluzole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mangosteen and Riluzole have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Mangosteen and Riluzole combination checked?
Interactions in our licensed database are recorded against drug classes. Riluzole is filed under 5 classifications, and Mangosteen has documented interactions with 2 drug classes — none of Riluzole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Mangosteen interact with any other medications?
Yes. Mangosteen has 125 documented drug interactions in our database — Riluzole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Riluzole interact with any supplements?
Yes. Riluzole has documented interactions with 141 supplements in our database — Mangosteen is not one of them. The Riluzole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mangosteen monograph Uses, safety profile, and every drug interaction in one place Riluzole drug information The full plain-English guide to this medication Riluzole supplement interactions Every supplement checked against Riluzole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Riluzole and Mangosteen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.