Drug & supplement interaction

Mangosteen + Naproxen Sodium

Naproxen Sodium brand name: Midol Extended Relief.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Mangosteen has a moderate interaction with Naproxen Sodium. Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Mangosteen and Naproxen Sodium

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Naproxen Sodium

Naproxen Sodium falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Mangosteen interacts with.

Theoretically, concomitant use of mangosteen with anticoagulant or antiplatelet drugs may increase the risk of bleeding.
In vitro and animal research shows that gamma-mangostin, a constituent of mangosteen, is a potent and competitive antagonist of the serotonin 2A (5-HT2A) receptor. Antagonism of the 5-HT2A receptor is believed to reduce platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing with naproxen (the pain reliever in Midol Extended Relief): on its own, it can already nudge up your bleeding risk a bit because it affects how your platelets stick together and can irritate the stomach lining. Mangosteen, in lab and animal studies, seems to lower platelet clumping too. So in theory, pairing the two could add up and make you more prone to bruising, nosebleeds, or stomach bleeding.

I want to be honest about how thin this evidence is. This concern comes only from test-tube and animal research, not from people, so it's more of a caution than a proven problem. Eating mangosteen as a fruit or juice is very unlikely to matter. With concentrated supplements, it's worth a quick word with your pharmacist or doctor, especially if you notice unusual bruising.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chairungsrilerd N, Furukawa K, Ohta T, et al. Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. Planta Med 1996;62:471-2.
  2. Furukawa, K., Chairungsrilerd, N., Ohta, T., Nozoe, S., and Ohizumi, Y. [Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. Nippon Yakurigaku Zasshi 1997;110 Suppl 1:153P-158P. PubMed
  3. Chairungsrilerd, N., Furukawa, K., Tadano, T., Kisara, K., and Ohizumi, Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. Br J Pharmacol. 1998

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Mangosteen Also Interacts With Other Medications

Mangosteen has 121 moderate, 3 minor known drug interactions in our database — the Naproxen Sodium one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 Minor 3 No known interaction 2,706 (incl. Naproxen Sodium)
Taking anything else?

Check Another of Your Medications Against Mangosteen

Covers the 2,830 medications we’ve checked against Mangosteen. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Naproxen Sodium

This page covers Mangosteen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naproxen Sodium page lists 311 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

Open the Naproxen Sodium interaction page

One more smart check

Taking Mangosteen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,201 real supplement products containing Mangosteen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mangosteen. Your product may carry other ingredients that interact with Naproxen Sodium too, on top of Mangosteen — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mangosteen and Naproxen Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mangosteen
Top 25%

#200 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Naproxen Sodium
Steady interest

#1,605 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Mangosteen

What is Mangosteen?

Mangosteen
  • Antioxidant support
  • Anti-inflammatory support
  • Immune support
  • Skin health
  • General wellness

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support, and general wellness, strong human evidence for these benefits is limited. It is likely fine as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Read the full Mangosteen monograph & all interactions
Keep checking

Other Drugs & Mangosteen

Browse every other medication we’ve checked against Mangosteen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
3Minor
2,705No known interaction
121 Moderate 3 Minor 2,705 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Mangosteen page.

Minor

3 interactions

No interaction 2,705 drugs checked — show the list

We also checked Mangosteen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,705 medications checked with no known interaction — see the full Mangosteen list.

See the full Mangosteen interactions page
See every supplement checked against Naproxen Sodium, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Mangosteen monograph › Uses, safety, and every drug interaction in one place Naproxen Sodium supplement interactions › Every supplement checked against Naproxen Sodium, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Mangosteen and Naproxen Sodium Together: Common Questions

Can you take Mangosteen with Naproxen Sodium?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Mangosteen and Naproxen Sodium interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Naproxen Sodium and Mangosteen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.