Drug & supplement interaction

Mangosteen + Memantine, Donepezil

Memantine, Donepezil brand name: Namzaric.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Mangosteen has a minor interaction with Memantine, Donepezil. Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Mangosteen and Memantine, Donepezil

Here is the interaction we found between these two, with the evidence behind it.

Minor

DONEPEZIL (Aricept)

Theoretically, concomitant use of mangosteen with donepezil might increase the effects of donepezil.
Animal research shows that concomitant use of an aqueous extract of mangosteen pericarp with donepezil increases brain concentrations of donepezil at 4 hours by 64% without associated effects on systemic exposure.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Namzaric combines two Alzheimer's medicines: memantine and donepezil. The piece that matters here is the donepezil. We have a small bit of animal research hinting that mangosteen might nudge more donepezil into the brain (one study saw about a 64% bump in brain levels at 4 hours), even though the amount in the bloodstream didn't really change.

If that held true in people, the worry would be a little more donepezil effect, which could mean more nausea, diarrhea, loss of appetite, vivid dreams, or a slower heartbeat. But honestly, this is theoretical and based only on lab and animal work, so I wouldn't lose sleep over it. Eating mangosteen fruit is unlikely to matter; concentrated supplements are the bigger question. Before adding any mangosteen supplement, just run it by your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Bae M, Han SY, Kim ES, et al. Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice. Molecules 2021;26(17):5246. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Mangosteen Also Interacts With Other Medications

Mangosteen has 122 moderate, 2 minor known drug interactions in our database — the Memantine, Donepezil one above is one of them. If you take anything else, check it against the full list below.

Moderate 122 Minor 2 No known interaction 2,706 (incl. Memantine, Donepezil)
Taking anything else?

Check Another of Your Medications Against Mangosteen

Covers the 2,830 medications we’ve checked against Mangosteen. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Memantine, Donepezil

This page covers Mangosteen only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine, Donepezil page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Threonine (major) and 1,3-dmaa (moderate).

By severity: 4 major · 126 moderate · 42 minor.

Open the Memantine, Donepezil interaction page

One more smart check

Taking Mangosteen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,201 real supplement products containing Mangosteen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mangosteen. Your product may carry other ingredients that interact with Memantine, Donepezil too, on top of Mangosteen — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mangosteen and Memantine, Donepezil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mangosteen
Top 25%

#201 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Memantine, Donepezil
Top 25%

#557 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Mangosteen

What is Mangosteen?

Mangosteen
  • Antioxidant support
  • Anti-inflammatory support
  • Immune support
  • Skin health
  • General wellness

Mangosteen is a tropical fruit whose rind is rich in plant compounds called xanthones that act as antioxidants. While it is popular in juices and supplements for inflammation, immune support, and general wellness, strong human evidence for these benefits is limited. It is likely fine as a food, but talk with your pharmacist or doctor before using concentrated supplements.

Read the full Mangosteen monograph & all interactions
Keep checking

Other Drugs & Mangosteen

Browse every other medication we’ve checked against Mangosteen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
2Minor
2,705No known interaction
122 Moderate 2 Minor 2,705 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Mangosteen page.

Minor

2 interactions

No interaction 2,705 drugs checked — show the list

We also checked Mangosteen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,705 medications checked with no known interaction — see the full Mangosteen list.

See the full Mangosteen interactions page
See every supplement checked against Memantine, Donepezil, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Mangosteen monograph › Uses, safety, and every drug interaction in one place Memantine, Donepezil supplement interactions › Every supplement checked against Memantine, Donepezil, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Mangosteen and Memantine, Donepezil Together: Common Questions

Can you take Mangosteen with Memantine, Donepezil?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Mangosteen and Memantine, Donepezil interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Memantine, Donepezil and Mangosteen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.