Drug & supplement interaction

Wild Indigo + Lidocaine

Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wild Indigo and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wild Indigo and Lidocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lidocaine and Wild Indigo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Wild Indigo at all — not against Lidocaine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wild Indigo safety at a glance

Wild Indigo overall Use caution It may be safe in small amounts short-term, but larger doses can be toxic and cause vomiting and other effects.
Pregnancy Likely Unsafe When used orally or topically due to its toxic potential. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally or topically due to its toxic potential. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lidocaine and Wild Indigo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Wild Indigo and Lidocaine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Wild Indigo

    “Orally, large doses of wild indigo are considered poisonous and can cause vomiting, diarrhea, gastrointestinal complaints, and spasms (12). Wild indigo has also been studied in combination with other herbal extracts.”

    Wild Indigo · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    “Orally, large doses of wild indigo can cause vomiting, diarrhea, and gastrointestinal complaints (12).”

    Wild Indigo · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

Reported for Wild Indigo but not commonly for Lidocaine: diarrhea.

Effects for Lidocaine come from the ADVERSE REACTIONS section of its FDA label; effects for Wild Indigo come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 96,036 voluntary FDA FAERS reports for Lidocaine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wild Indigo in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally or topically due to its toxic potential.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Lidocaine

This page covers Wild Indigo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 111 moderate · 31 minor.

From our pharmacist’s overview on the Lidocaine page

“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Lidocaine interaction page

One more smart check

Taking Wild Indigo as Part of a Dietary Supplement Product? Check It for Interactions

We hold 175 real supplement products containing Wild Indigo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wild Indigo. Even though Wild Indigo itself has no known interaction with Lidocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wild Indigo and Lidocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wild Indigo
Steady interest

#867 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lidocaine
Top 25%

#330 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wild Indigo reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wild Indigo and Lidocaine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wild Indigo

What is Wild Indigo?

  • Colds and flu
  • Immune support
  • Sore throat and upper respiratory infections
  • Minor infections
  • Mouth and gum irritation (traditional use)

Wild Indigo (Baptisia tinctoria) is a traditional herb most often used in combination products for colds and immune support, but high-quality human evidence is very limited. It can be toxic in larger amounts, so it should be used cautiously and only at low doses, and avoided in pregnancy and breastfeeding.

Baptisia tinctoria · Fabaceae · Root (and sometimes the leaves) · Tinctures, capsules, dried root for tea, and combination herbal products (often blended with echinacea and thuja)

An interaction check asks whether these two react with each other — it does not ask whether Wild Indigo is a good idea for someone in your situation. Here is what our Wild Indigo record says about it on its own.

Wild Indigo: dosing

There is no well-established standardized dose for wild indigo. It is most often found in small amounts within combination products, where the manufacturer sets the dose.Because the herb can be toxic at higher amounts, it is important to follow the product label exactly and not exceed the recommended dose. Do not assume that more is better.

From our Wild Indigo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wild Indigo monograph & all interactions
Medication

About Lidocaine Transdermal Patch

What Is Lidocaine Transdermal Patch Used For?

Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido

Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.

Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.

Most-Reported Side Effects for Lidocaine

From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,961 reports
Fatigue 4,867 reports
Headache 4,439 reports
Product quality issue 3,920 reports
Dyspnea 3,658 reports
See full Lidocaine Transdermal Patch drug information
Keep checking

Other Drugs & Wild Indigo

Browse every other medication we’ve checked against Wild Indigo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Wild Indigo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Wild Indigo list.

See the full Wild Indigo interactions page
See every supplement checked against Lidocaine, ranked by severity
Evidence & sources

Wild Indigo References

The 3 references that drive our Wild Indigo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Henneicke-von Zepelin H, Hentschel C, Schnitker J, et al. Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection): results of a randomised, double blind, placebo-controlled, m

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wild Indigo and Lidocaine Together: Common Questions

Is it safe to take Wild Indigo with Lidocaine?
We do not list a known interaction between Wild Indigo and Lidocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wild Indigo and Lidocaine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Lidocaine interact with any supplements?
Yes. Lidocaine has documented interactions with 145 supplements in our database — Wild Indigo is not one of them. The Lidocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wild Indigo monograph Uses, safety profile, and every drug interaction in one place Lidocaine Transdermal Patch drug information The full plain-English guide to this medication Lidocaine supplement interactions Every supplement checked against Lidocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lidocaine and Wild Indigo?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.