FDA-filed SPL labeling · retrieved through openFDA

Lidocaine

Lidocaine is a local anesthetic used across many products to temporarily relieve pain, itching, and skin irritation — and, by injection, to produce regional or nerve-block anesthesia during procedures.

Brand names XylocaineAktenLidodermZingoSolarcaine +11 more
Drug classes ⓘ Amide Local Anesthetic
Rx/OTC Forms 7 Routes Topical · Infiltration, Perineural · Infiltration; Perineural · Epidural, Infiltration, Intracaudal, Perineural +13
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1,022 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveNov 1, 2024
Clinical labels in scope ⓘ1,022
AvailabilityRx/OTC
Earliest approval/marketing year ⓘ1948
FDA-listed product records ⓘ2,515
Boxed warningYes
How we combine label and product data →
Other forms & routes:
Transdermal
⭐ Lidocaine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Lidocaine is a widely used local anesthetic that relieves pain, itching, and skin discomfort in many topical forms — and provides procedural anesthesia when injected by trained clinicians. Topical products are generally well tolerated when used as directed, but it's important not to use too much, avoid heating pads over patches, and keep used patches away from children and pets. If you experience unusual skin color changes, severe reactions, or any signs of a serious reaction, get medical help right away.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS WARNING: SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed warning. Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants ( 5.1 ) Monitor for worsening and emergence of suicidal thoughts and behaviors ( 5.1 ) Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did no...

Read the full warning on DailyMed →

📖 Lidocaine: Patient Information Guide

A plain-language walkthrough of Lidocaine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Lidocaine is a local anesthetic available in many forms, each approved for specific uses.

  • Temporary relief of pain, itching, and burning from minor burns, sunburn, cuts, scrapes, insect bites, and minor skin irritations (topical creams, gels, patches, and sprays)
  • Relief of discomfort, itching, and pain from hemorrhoids, anal fissures, pruritus ani, pruritus vulvae, and related conditions of the skin and mucous membranes (Lidocaine Hydrochloride cream)
  • Temporary relief of muscle soreness and minor joint pain in the back, knees, wrists, neck, hips, shoulders, and elbows (Lidocaine Pain Relief Gel-Patch)
  • Temporary male genital desensitization to help slow ejaculation and reduce oversensitivity (Dynamo Delay, Dynamo Delay Sample Bottle sprays; INTIMALE Maximum Strength Delay and SKINS DELAY Maximum Strength Lidocaine topical solutions)
  • Local and regional anesthesia during medical procedures, including infiltration, nerve blocks (such as brachial plexus and intercostal blocks), and epidural blocks (Accucaine and Xylocaine injections — administered only by trained clinicians)
⚙️How it works▾

Lidocaine works by blocking the nerve signals that cause pain. It stabilizes the nerve cell membrane by preventing sodium ions from flowing into the nerve cell — and without that flow, the nerve can't fire or send a pain signal. The result is temporary numbness or reduced sensation in the treated area.

When lidocaine reaches high blood levels (which is a risk mainly with injections or misuse of topical products), it can also affect the heart and central nervous system, which is why injectable forms require careful medical supervision.

💊How it's taken▾

How you take lidocaine depends on the product and its intended use.

  • Skin patches: Apply to clean, dry skin. Most brands are used up to 3–4 times daily; some allow up to 12 hours of wear per patch. Follow the specific product's label for patch duration and how many patches per day.
  • Creams and gels: Apply a thin layer to the affected area, typically every 6–8 hours, no more than 3–4 times per day. Wash hands after applying.
  • Topical sprays: Spray onto the affected skin 2–4 times daily depending on the product. Some delay sprays require application a few minutes before intercourse.
  • Injections: Only administered by a trained healthcare provider. The dose, volume, and technique are determined by the type of procedure and the patient's condition.

Always follow your product's label or your prescriber's instructions. Do not use more than directed.

🤒Side effects — in detail▾

Topical lidocaine products are generally well tolerated, but some people experience skin reactions at the application site.

  • Redness, irritation, or itching where applied
  • Skin rash or blistering
  • Swelling or pain at the site
  • Burning or stinging sensation

Stop use and contact your doctor if skin reactions worsen, blistering develops, or symptoms don't improve after 7 days. With injections, serious side effects including seizures, irregular heartbeat, and loss of consciousness can occur if too much drug enters the bloodstream — these require emergency medical care immediately.

⚠️Warnings & precautions▾
  • Methemoglobinemia (blood oxygen problem): All local anesthetics can rarely cause this dangerous condition, where the blood loses its ability to carry oxygen properly. Signs include bluish or grayish skin color. People with G6PD deficiency, heart or lung problems, and infants under 6 months are at highest risk. Get emergency help immediately if this is suspected.
  • High blood levels and toxicity: Too much lidocaine absorbed into the bloodstream — especially with injections — can cause seizures, dangerously slow or irregular heart rhythms, and cardiac arrest. Injectable lidocaine must only be given by trained clinicians with emergency equipment on hand.
  • Heating pads and skin patches: Applying heat over a lidocaine patch significantly increases the amount absorbed into your body. Never use a heating pad on or near a lidocaine patch.
  • Used patch safety: Used patches still contain active lidocaine. Dispose of them by folding the sticky sides together and keep them away from children and pets — swallowing a patch can cause serious harm.
  • Do not use on damaged skin: Avoid applying to open wounds, puncture wounds, or inflamed or blistered skin unless a doctor directs you to.
  • Allergic reactions: Serious allergic reactions, including anaphylaxis, can occur. Stop use and get emergency help if you have trouble breathing, swelling, or severe rash.
🔀What it interacts with▾

Lidocaine can interact with other substances — here's what to be aware of:

  • Other topical anesthetics: Using multiple lidocaine-containing products or other local anesthetic products at the same time increases the total amount absorbed — this raises the risk of side effects. Tell your provider about every product you're using.
  • Heat sources: Applying a heating pad over a lidocaine skin patch sharply increases drug absorption into the bloodstream, raising the risk of toxicity.
  • Oxidizing agents and certain medications: Some drugs that act as oxidizing agents can increase the risk of methemoglobinemia when used with local anesthetics. Ask your pharmacist or doctor about any medications you take.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Pregnancy or breastfeeding: Ask a health professional before using any lidocaine product. Lidocaine can cross the placental barrier.
  • Children: Most topical products are not recommended for children under 12 without a doctor's guidance; some products specify age 2 or 4 as the minimum. Always check the label for the specific product.
  • G6PD deficiency (a genetic enzyme deficiency): Higher risk of methemoglobinemia — tell your doctor before using.
  • Heart or lung conditions: May increase risk of serious effects if significant lidocaine is absorbed — discuss with your provider.
  • Liver disease: Lidocaine is metabolized by the liver; reduced liver function slows processing and can lead to higher drug levels in the body.
  • Allergy to local anesthetics: Do not use if you've had an allergic reaction to lidocaine or similar anesthetics before.
  • Infants under 6 months: At higher risk of methemoglobinemia; use only under close medical supervision.
🚑If you take too much▾

Serious problems from lidocaine are most often related to high levels in the bloodstream — from too much absorbed through the skin, or from an injection reaching a blood vessel. Signs include seizures, loss of consciousness, very slow or irregular heartbeat, and difficulty breathing. If any of these occur, seek emergency medical care immediately. Poison Control should be contacted right away if a child or pet swallows a lidocaine patch.

📡Pharmacodynamics — effects in the body▾

At normal doses, lidocaine blocks nerve impulses in the treated area, producing localized numbness without affecting the whole body. If blood levels become excessively high, lidocaine can affect the heart — causing changes in cardiac output and blood pressure, and potentially dangerous heart rhythm problems. These cardiovascular effects are the primary concern with injectable forms and with misuse of topical products.

🔬Pharmacokinetics — how your body processes it▾

With topical skin patches, the amount absorbed into the body depends on how long the patch is worn and how large an area it covers. Applying heat increases absorption significantly. Lidocaine is processed quickly by the liver into metabolites that have mild anesthetic activity of their own, and both the drug and its metabolites are cleared by the kidneys. After an intravenous dose, the half-life (the time it takes the body to clear half the drug) is roughly 1.5 to 2.5 hours; liver problems can extend this significantly. Less than 10% of the drug leaves the body unchanged in urine.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) .

📄 Written from Lidocaine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Lidocaine — the kind of thing our pharmacy team would talk through with you at the counter.

Can I use a lidocaine patch and a lidocaine cream at the same time? ▾
It's best to avoid using two lidocaine products at the same time unless your doctor says it's okay. When you use multiple products containing a local anesthetic, the total amount absorbed into your body adds up — and too much lidocaine in your bloodstream can cause serious side effects. Always tell your pharmacist or doctor about every product you're using, including over-the-counter options.
Can I put a heating pad on the area where I applied a lidocaine patch? ▾
No — please don't do this. Heat significantly increases how much lidocaine is absorbed through your skin, which can push drug levels in your blood higher than they should be. Stick to using the patch as directed, without any added heat sources like heating pads or hot water bottles over it.
What should I do with a used lidocaine patch? ▾
Used patches still contain a meaningful amount of lidocaine — enough to seriously harm a child or pet if they chew or swallow it. The label recommends folding the patch so the sticky sides stick together, then disposing of it safely out of reach of children and pets. Don't leave used patches lying around.
Is it safe to use lidocaine products if I'm pregnant? ▾
Most product labels say to ask a health professional before using lidocaine if you're pregnant or breastfeeding. Lidocaine can cross the placental barrier. It's not automatically off-limits, but you should check with your doctor or midwife first so they can weigh the benefit against any potential risk for your situation.
How do I know if I'm having a serious reaction to lidocaine? ▾
Most people just get some mild skin redness or irritation where they applied the product. The signs that mean you should stop use and get help right away include a bluish or grayish color to your skin (which can signal a blood oxygen problem called methemoglobinemia), signs of a severe allergic reaction like swelling or trouble breathing, or — with injections — seizures or irregular heartbeat. If anything feels seriously wrong, don't wait: call emergency services or go to the nearest emergency room.
Can my child use a lidocaine skin patch or cream? ▾
It depends on the specific product and your child's age. Most lidocaine patches and creams are labeled for adults and children 12 and older. Some gels and sprays have a lower age limit of 2 or 4 years. Children under 12 — and especially infants — should only use lidocaine products under a doctor's guidance, since they're more sensitive to the drug's effects. Always check the individual product label and call your child's doctor if you're unsure.
Is Lidocaine available over the counter? ▾
Both — Lidocaine is sold both over the counter and by prescription, according to its FDA labeling. Lower strengths or certain forms are often available without a prescription, while higher strengths or specialized forms still require one. Ask your pharmacist which version is right for you.
When was Lidocaine first available? ▾
Lidocaine has been available in the United States since at least 1948, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Lidocaine? ▾
Lidocaine is supplied by 632 manufacturers listed in the FDA NDC Directory, including Henry Schein, Inc., HF Acquisition Co LLC, DBA HealthFirst, Hospira, Inc..

💬 Answers drafted from Lidocaine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

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💊 How Lidocaine comes

Lidocaine is available in 7 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Topical cream, ointment or gel

On the skin
Brands Dr. Numb
How this form is used
What it may be used for
  • Alocane Emergency Burn gel is used for temporary relief of minor burn pain
  • Lidocaine Hydrochloride cream is used for relief of itching, minor burns, insect bites, pain from hemorrhoids, anal fissures, and similar conditions of the skin and mucous membranes
  • DermacinRx Lidotral cream is used for temporary relief of pain and itching from minor burns, sunburn, minor cuts, scrapes, insect bites, and minor skin irritation
  • Hilook Blue Gel Anesthetic is applied as a topical anesthetic after cleaning the skin
Important instructions
  • DCH Pain Relief cream: adults and children over 12 — apply a thin layer every 6–8 hours, no more than 3 applications in 24 hours; wash hands after applying; children under 12 should ask a doctor
  • Alocane Emergency Burn gel: clean the burn with mild soap and water, gently apply; use no more than 3–4 times daily; children under 2 should see a doctor
  • Hilook Blue Gel Anesthetic: apply an appropriate amount to the area, massage gently for a few minutes, and wait 15–30 minutes for full anesthetic effect
  • Do not use in large quantities, particularly over raw surfaces or blistered areas
Available strengths 17 strengths
5 mg/g 8 mg/g 20 mg/g 20 mg/mL 40 mg/g 40 mg/mL
Show 11 more strengths Show fewer strengths
0.05 g/g 50 mg/g 50 mg/mL 0.5 g/100 g 2 g/100 g 4 g/80 g 4 g/100 g 4 g/100 mL 5 g/100 g 5 g/100 mL 5.05 g/g
762 FDA-listed product records ⓘ

Skin patch

On the skin · Through the skin
Brands Lidoderm
How this form is used
What it may be used for
  • Lidocaine Pain Relief Gel-Patch is used for temporary relief of muscle soreness and minor joint pain in the wrist, knees, back, neck, hips, shoulders, and elbows
  • Aspercreme, Biofreeze Ultraflex, Curist Lidocaine Patch, and Lidocore patches are used for temporary relief of pain
Important instructions
  • Aspercreme: clean and dry the affected area, peel the backing from the center outward, and apply to skin — for adults and children 12 and older; apply up to 3–4 times daily
  • Biofreeze Ultraflex: apply one patch at a time, leave in place for up to 8 hours, up to 3–4 times daily; wash hands with cool water after use; consult a physician for children under 12
  • Curist Lidocaine Patch: apply one patch for up to 12 hours, discard after single use; do not use more than 3–4 times daily; children under 12 should consult a doctor
  • Do not apply a heating pad over any lidocaine patch — heat significantly increases drug absorption into the bloodstream
Available strengths 13 strengths
4 mg/100 mg LIDOCAINE 18 mg/116cm2 0.04 g 0.04 g/g 40 mg 40 mg/g
Show 7 more strengths Show fewer strengths
50 mg/g 246 mg 560 mg 700 mg 4 g 4 g/100 g 4 g/1001
430 FDA-listed product records ⓘ

Injection

Infiltration · Into a vein · Into the epidural space · Intracaudal · Perineural
Brands Xylocaine
How this form is used
What it may be used for
  • Accucaine is used to produce local or regional anesthesia by infiltration injection and intravenous regional anesthesia
  • Xylocaine is used for peripheral nerve blocks (such as brachial plexus and intercostal blocks) and central neural techniques (such as lumbar and caudal epidural blocks)
Important instructions
  • Accucaine and Xylocaine injections must be administered only by trained clinicians with resuscitation equipment immediately available
  • Aspiration should be performed before injecting to avoid accidental intravascular injection
  • Xylocaine solutions containing preservatives should not be used for epidural or spinal anesthesia
  • Dosing is determined by the procedure, the patient, and the clinical situation — never self-administer
Available strengths 3 strengths
5 mg/mL 10 mg/mL 20 mg/mL
370 FDA-listed product records ⓘ

Topical solution

By mouth · On the skin
Brands INTIMALE Maximum Strength Delay SKINS DELAY Maximum Strength Lidocaine
How this form is used
What it may be used for
  • INTIMALE Maximum Strength Delay is used for temporary male genital desensitization to help slow the onset of ejaculation
  • SKINS DELAY Maximum Strength Lidocaine is used for temporary male genital desensitization and to reduce oversensitivity before intercourse
Important instructions
  • INTIMALE: apply 3–5 minutes before intercourse; shake gently before use; apply 3 or more sprays to the head and shaft of the penis and massage for about 20 seconds; do not exceed 10 sprays; wash hands thoroughly after use
  • SKINS DELAY: apply 3 or more sprays and massage until absorbed; wait to feel the full effect before applying more; do not exceed 10 sprays; wash hands thoroughly after use
Available strengths 6 strengths
10 mg/mL 20 mg/mL 40 mg/mL 4 g/100 g 4 g/100 mL 4 g/mL
167 FDA-listed product records ⓘ

Topical spray

On the skin
Brands Solarcaine
How this form is used
What it may be used for
  • Dynamo Delay and Dynamo Delay Sample Bottle sprays are used for temporary male genital desensitization to help slow ejaculation and reduce oversensitivity
  • Lidotral Two Percent and Lidotral Five Percent sprays are used for temporary relief of pain and itching from minor burns, sunburn, cuts, scrapes, insect bites, and minor skin irritation
  • DCH Pain Relief spray is used for temporary relief of pain applied to the affected area
Important instructions
  • Lidotral Two Percent: spray to the affected area 2–3 times daily or as directed by a healthcare provider; apply to intact skin only; consult a provider for children under 4
  • Lidotral Five Percent: spray to the affected area 2–3 times daily or as directed; apply to intact skin only; use smaller treatment areas in debilitated patients or those with reduced elimination
  • DCH Pain Relief spray: adults and children 2 years and older — apply to the affected area no more than 3–4 times daily; to apply to the face, spray into the palm first then gently apply; children under 2 should see a physician
  • When using any lidocaine spray alongside other local anesthetic products, the total amount absorbed from all products must be considered
Available strengths 6 strengths
10 mg/mL 20 mg/mL 2 g/100 mL 4 g/100 g 4 g/100 mL 20 g/L
63 FDA-listed product records ⓘ

Oral solution

By mouth · Oropharyngeal
Available strengths 2 strengths
20 mg/mL 40 mg/mL
20 FDA-listed product records ⓘ

Ear drops

In the ear
Available strengths 1 strength
40 mg/mL
5 FDA-listed product records ⓘ

📊 Lidocaine across the U.S. market

How Lidocaine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

7
Dose forms ⓘ
632
Manufacturers
40
Brand names
2,515
FDA-listed product records ⓘ
1948
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (48) · Kit (47) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Henry Schein, Inc.5%
HF Acquisition Co LLC, DBA HealthFirst5%
Hospira, Inc.5%
Chattem, Inc.5%
Veridian Healthcare5%
PureTek Corporation4%
Other makers71%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Lidocaine is used

A general measure of how commonly Lidocaine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Lidocaine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

3,379,243
Medicaid prescriptions filled (Q1–Q4 2025)
$233.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Lidocaine prescribed? Of the 1,596 medications we measure, Lidocaine ranks #62 by Medicaid prescriptions — more than 96% of them.

Where Lidocaine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #62 of 1,596
#57 Clonazepam 3,602,972 Rx #58 Fluconazole 3,462,620 Rx #59 Polyethylene Glycol 33... 3,441,581 Rx #60 Doxycycline 3,416,939 Rx #61 Risperidone 3,411,596 Rx #62 Lidocaine 3,379,243 Rx #63 Budesonide / Formotero... 3,326,951 Rx #64 Meloxicam 3,321,801 Rx #65 Folic Acid 3,298,551 Rx #66 Metronidazole 3,247,421 Rx #67 Hydrochlorothiazide 3,216,975 Rx

Utilization by Lidocaine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.05 mg/mg medicated patch is the most-dispensed Lidocaine product — about 42% of these Medicaid prescriptions.

lidocaine 0.05 MG/MG Medicated Patch Most dispensed

1,403,004 Medicaid prescriptions (Q1–Q4 2025) 42% of Lidocaine prescriptions shown $97.6M gross reimbursement (before rebates) ≈ $70 per prescription (gross)

Summed across the 9 of 137 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1745091

lidocaine 0.04 MG/MG Medicated Patch

621,230 Medicaid prescriptions (Q1–Q4 2025) 18% of Lidocaine prescriptions shown $20.7M gross reimbursement (before rebates) ≈ $33 per prescription (gross)

Summed across the 17 of 893 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737778

lidocaine hydrochloride 20 MG/ML Mucous Membrane Topical Solution

404,036 Medicaid prescriptions (Q1–Q4 2025) 12% of Lidocaine prescriptions shown $7.1M gross reimbursement (before rebates) ≈ $17 per prescription (gross)

Summed across the 7 of 54 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010739

lidocaine 0.05 MG/MG Topical Ointment

247,271 Medicaid prescriptions (Q1–Q4 2025) 7% of Lidocaine prescriptions shown $6.3M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 20 of 149 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1543069

lidocaine 0.018 MG/MG Medicated Patch

122,681 Medicaid prescriptions (Q1–Q4 2025) 4% of Lidocaine prescriptions shown $67.5M gross reimbursement (before rebates) ≈ $550 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2001434

lidocaine hydrochloride 10 MG/ML Injectable Solution

98,669 Medicaid prescriptions (Q1–Q4 2025) 3% of Lidocaine prescriptions shown $4.7M gross reimbursement (before rebates) ≈ $47 per prescription (gross)

Summed across the 21 of 102 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010033

5 ML lidocaine hydrochloride 20 MG/ML Injection

97,804 Medicaid prescriptions (Q1–Q4 2025) 3% of Lidocaine prescriptions shown $7.6M gross reimbursement (before rebates) ≈ $78 per prescription (gross)

Summed across the 14 of 68 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737761

lidocaine 40 MG/ML Topical Cream

66,342 Medicaid prescriptions (Q1–Q4 2025) 2% of Lidocaine prescriptions shown $2M gross reimbursement (before rebates) ≈ $30 per prescription (gross)

Summed across the 8 of 125 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1421893

5 ML lidocaine hydrochloride 10 MG/ML Injection

60,565 Medicaid prescriptions (Q1–Q4 2025) 2% of Lidocaine prescriptions shown $4.6M gross reimbursement (before rebates) ≈ $76 per prescription (gross)

Summed across the 15 of 66 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737566

lidocaine hydrochloride 20 MG/ML Injectable Solution

45,652 Medicaid prescriptions (Q1–Q4 2025) 1% of Lidocaine prescriptions shown $3.2M gross reimbursement (before rebates) ≈ $71 per prescription (gross)

Summed across the 16 of 87 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010671

lidocaine hydrochloride 30 MG/ML Topical Cream

44,257 Medicaid prescriptions (Q1–Q4 2025) 1% of Lidocaine prescriptions shown $1.9M gross reimbursement (before rebates) ≈ $43 per prescription (gross)

Summed across the 6 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010835

30 ML lidocaine hydrochloride 10 MG/ML Injection

25,595 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $1.2M gross reimbursement (before rebates) ≈ $45 per prescription (gross)

Summed across the 6 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737562

lidocaine hydrochloride 0.02 MG/MG Topical Gel

23,374 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $61 per prescription (gross)

Summed across the 7 of 99 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1011852

2 ML lidocaine hydrochloride 10 MG/ML Injection

23,335 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $1.3M gross reimbursement (before rebates) ≈ $54 per prescription (gross)

Summed across the 10 of 44 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737568

5 ML lidocaine hydrochloride 20 MG/ML Prefilled Syringe

21,113 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $2M gross reimbursement (before rebates) ≈ $95 per prescription (gross)

Summed across the 2 of 20 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1012068

lidocaine hydrochloride 40 MG/ML Topical Cream

18,433 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $201,915 gross reimbursement (before rebates) ≈ $11 per prescription (gross)

Summed across the 2 of 98 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010895

2 ML lidocaine hydrochloride 20 MG/ML Injection

12,688 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $638,448 gross reimbursement (before rebates) ≈ $50 per prescription (gross)

Summed across the 8 of 34 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737757

lidocaine hydrochloride 40 MG/ML Mucous Membrane Topical Solution

5,839 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $177,928 gross reimbursement (before rebates) ≈ $30 per prescription (gross)

Summed across the 6 of 23 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010878

10 ML lidocaine hydrochloride 20 MG/ML Injection

3,707 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $727,078 gross reimbursement (before rebates) ≈ $196 per prescription (gross)

Summed across the 2 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737763

lidocaine 50 MG/ML Rectal Cream

3,608 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $98,183 gross reimbursement (before rebates) ≈ $27 per prescription (gross)

Summed across the 3 of 112 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1366789

50 ML lidocaine hydrochloride 5 MG/ML Injection

1,679 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $99,595 gross reimbursement (before rebates) ≈ $59 per prescription (gross)

Summed across the 2 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737343

500 ML lidocaine hydrochloride 4 MG/ML Injection

1,314 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $2,036 gross reimbursement (before rebates) ≈ $1.55 per prescription (gross)

Summed across the 2 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737744

5 ML lidocaine hydrochloride 40 MG/ML Injection

856 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $114,486 gross reimbursement (before rebates) ≈ $134 per prescription (gross)

Summed across the 1 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010844

10 ML lidocaine hydrochloride 10 MG/ML Injection

822 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $95,577 gross reimbursement (before rebates) ≈ $116 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737570

lidocaine hydrochloride 0.028 MG/MG Topical Gel

487 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $755,502 gross reimbursement (before rebates) ≈ $1,551 per prescription (gross)

Summed across the 1 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2562183

lidocaine hydrochloride 38.8 MG/ML Topical Cream

341 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $303,824 gross reimbursement (before rebates) ≈ $891 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1723991

250 ML lidocaine hydrochloride 8 MG/ML Injection

279 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $2,130 gross reimbursement (before rebates) ≈ $7.63 per prescription (gross)

Summed across the 2 of 5 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737723

lidocaine hydrochloride 5 MG/ML Injectable Solution

103 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $1,033 gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1010900

lidocaine hydrochloride 0.035 MG/MG Ophthalmic Gel

90 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1009462

5 ML lidocaine hydrochloride 10 MG/ML Prefilled Syringe

79 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $6,597 gross reimbursement (before rebates) ≈ $84 per prescription (gross)

Summed across the 1 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1012066

250 ML lidocaine hydrochloride 4 MG/ML Injection

13 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $29 gross reimbursement (before rebates) ≈ $2.24 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737742

20 ML lidocaine hydrochloride 15 MG/ML Injection

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $10 gross reimbursement (before rebates) ≈ $0.87 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1737636

Other Lidocaine products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

23,966 Medicaid prescriptions (Q1–Q4 2025) <1% of Lidocaine prescriptions shown $1.5M gross reimbursement (before rebates) ≈ $62 per prescription (gross)

Summed across the 12 of 610 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Lidocaine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 207 of 2,837 listed Lidocaine NDCs with Medicaid activity.

🔍 Compare Lidocaine products

A representative set of FDA-listed product records for Lidocaine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 2,515 products — FDA National Drug Code Directory. See every product, package size and price: browse all 2,515 Lidocaine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Lidocaine RxCUI 6387 22 dose forms · 104 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 372599 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 1 MG/ML RxCUI 1010694 hydrochloride 10 MG/ML RxCUI 1010033 hydrochloride 2 MG/ML RxCUI 1012019 hydrochloride 20 MG/ML RxCUI 1010671 hydrochloride 5 MG/ML RxCUI 1010900 hydrochloride 6 MG/ML RxCUI 1013004
  2. Dose form (SCDF) Injection RxCUI 1737342 In current FDA listings
    Clinical drug / strength (SCD) 2 ML lidocaine hydrochloride 10 MG/ML RxCUI 1737568 2 ML lidocaine hydrochloride 20 MG/ML RxCUI 1737757 2 ML lidocaine hydrochloride 50 MG/ML RxCUI 1011093 5 ML lidocaine hydrochloride 10 MG/ML RxCUI 1737566 5 ML lidocaine hydrochloride 20 MG/ML RxCUI 1737761 5 ML lidocaine hydrochloride 40 MG/ML RxCUI 1010844 10 ML lidocaine hydrochloride 10 MG/ML RxCUI 1737570 10 ML lidocaine hydrochloride 15 MG/ML RxCUI 1737640 10 ML lidocaine hydrochloride 20 MG/ML RxCUI 1737763 20 ML lidocaine hydrochloride 15 MG/ML RxCUI 1737636 30 ML lidocaine hydrochloride 10 MG/ML RxCUI 1737562 50 ML lidocaine hydrochloride 5 MG/ML RxCUI 1737343 250 ML lidocaine hydrochloride 4 MG/ML RxCUI 1737742 250 ML lidocaine hydrochloride 8 MG/ML RxCUI 1737723 500 ML lidocaine hydrochloride 4 MG/ML RxCUI 1737744 500 ML lidocaine hydrochloride 8 MG/ML RxCUI 1737735
  3. Dose form (SCDF) Jet Injector RxCUI 1672969 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.5 MG RxCUI 1011707
  4. Dose form (SCDF) Medicated Bar Soap RxCUI 1535616 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.005 MG/MG RxCUI 1535617
  5. Dose form (SCDF) Medicated Liquid Soap RxCUI 1999988 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 40 MG/ML RxCUI 2604567
  7. Dose form (SCDF) Medicated Patch RxCUI 1792943 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.04 MG/MG RxCUI 1012994 0.018 MG/MG RxCUI 2001434 0.035 MG/MG RxCUI 2199665 0.04 MG/MG RxCUI 1737778 0.0488 MG/MG RxCUI 2680724 0.05 MG/MG RxCUI 1745091
  8. Dose form (SCDF) Mucosal Spray RxCUI 393257 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 100 MG/ML RxCUI 1010053
  10. Dose form (SCDF) Ophthalmic Gel RxCUI 809468 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 0.035 MG/MG RxCUI 1009462
  11. Dose form (SCDF) Otic Solution RxCUI 1372898 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 40 MG/ML RxCUI 2595042
  15. Dose form (SCDF) Rectal Spray RxCUI 2624686 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 50 MG/ML RxCUI 2624687 50 MG/ML RxCUI 2637486
  16. Dose form (SCDF) Rectal Suppository RxCUI 2474634 No current FDA listing
    Clinical drug / strength (SCD) 50 MG RxCUI 2474635
  17. Dose form (SCDF) Topical Cream RxCUI 377740 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 20 MG/ML RxCUI 1432482 hydrochloride 30 MG/ML RxCUI 1010835 hydrochloride 32.5 MG/ML RxCUI 1593733 hydrochloride 37.5 MG/ML RxCUI 1600130 hydrochloride 38.8 MG/ML RxCUI 1723991 hydrochloride 40 MG/ML RxCUI 1010895 hydrochloride 41.2 MG/ML RxCUI 1947197 hydrochloride 50 MG/ML RxCUI 1491882 20 MG/ML RxCUI 106222 30 MG/ML RxCUI 2049533 39 MG/ML RxCUI 2108915 40 MG/ML RxCUI 1421893 50 MG/ML RxCUI 1534792
  18. Dose form (SCDF) Topical Gel RxCUI 377965 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.005 MG/MG RxCUI 1011849 hydrochloride 0.01 MG/MG RxCUI 1012204 hydrochloride 0.015 MG/MG RxCUI 2000538 hydrochloride 0.02 MG/MG RxCUI 1011852 hydrochloride 0.025 MG/MG RxCUI 1009433 hydrochloride 0.028 MG/MG RxCUI 2562183 hydrochloride 0.03 MG/MG RxCUI 1372891 hydrochloride 0.0388 MG/MG RxCUI 2675768 hydrochloride 0.04 MG/MG RxCUI 1010077 hydrochloride 0.05 MG/MG RxCUI 1010057 0.008 MG/MG RxCUI 1098616 0.04 MG/MG RxCUI 1291672
  20. Dose form (SCDF) Topical Ointment RxCUI 372598 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 0.025 MG/MG RxCUI 1009416 hydrochloride 0.04 MG/MG RxCUI 1858984 hydrochloride 0.05 MG/MG RxCUI 1010296 0.04 MG/MG RxCUI 2559400 0.05 MG/MG RxCUI 1543069
  21. Dose form (SCDF) Topical Solution RxCUI 372600 In current FDA listings
    Clinical drug / strength (SCD) hydrochloride 20 MG/ML RxCUI 1010774 hydrochloride 25 MG/ML RxCUI 1012955 hydrochloride 40 MG/ML RxCUI 1987647 hydrochloride 50 MG/ML RxCUI 2670601 30 MG/ML RxCUI 2607527 40 MG/ML RxCUI 2197844

Look up RxCUI 6387 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Xylocaine Akten Lidoderm Zingo Solarcaine Regenecare Cutiecaine Burn Jel Plus Sonacaine Zcaine Dr. Numb Unburn AneCream Lmx Lidocream Recticare

🏭 Manufacturers & labelers

Henry Schein, Inc. 48 HF Acquisition Co LLC, DBA HealthFirst 47 Hospira, Inc. 47 Chattem, Inc. 46 Veridian Healthcare 44 PureTek Corporation 39 Fresenius Kabi USA, LLC 36 Bryant Ranch Prepack 36 Medical Purchasing Solutions, LLC 36 Eugia US LLC 34 A-S Medication Solutions 28 CVS Pharmacy 27 Remedyrepack Inc. 27 Asclemed USA, Inc. 24 Preferred Pharmaceuticals Inc. 24 Lifestar Pharma LLC 23 Sambria Pharmaceuticals, LLC 20 Hikma Pharmaceuticals USA Inc. 20 Walgreen Company 20 Advanced Rx Pharmacy of Tennessee, LLC 19 Clinical Resolution Laboratory, Inc. 19 Yyba Corp 18 NuCare Pharmaceuticals,Inc. 17 Guangzhou Liuquanmiao Import & Export Trade Co., Ltd. 16

…and 16 more on the FDA NDC directory.

RxNorm drug class

Lidocaine belongs to the Antiarrhythmic class.

Pharmacologic class Antiarrhythmic, Amide Local Anesthetic
Drug family (ATC) Antiarrhythmics, class Ib, Local anesthetics, Anesthetics for topical use

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Nov 1, 2024
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Lidocaine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Lidocaine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
1,022
NDC products indexed
2,515
Distinct labelers/manufacturers represented
632
Linked representative label ⓘ
Scilex Pharmaceuticals Inc.
Linked label effective
Nov 1, 2024
Composite sections available
27
Linked SPL Set ID
a1b17507-4560-490d-a388-74e7fd7eaa5e
Linked SPL Document ID
25e03ec1-e3a9-2483-e063-6394a90ad2d8
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 1,022 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Scilex Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.