Lidocaine

33 interactions 1 explained in plain English
Also sold as: Akten Alocane Bruselix Burn Jel Plus Cutiecaine Derma Numb Glydo Hexa-Caine Lidoguard Lidostat Lidotral Lidotran Lydexa RadiaGuard Regenecare Solarcaine Topicaine Ultra Tranzarel Uber Numb Unburn Xolido Xylocaine Zingo Zionodil
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nitroglycerin Transdermal Patch Hydroxychloroquine Nadolol Metoclopramide Injection Metoclopramide Nasal Spray Ifosfamide Injection
30 Major 2 Moderate 1 Minor
All (33) Major (30) Moderate (2) Minor (1)

Major

Lidocaine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of methemoglobinemia Details Lidocaine Acetaminophen Acephen An increased risk of methemoglobinemia Details Lidocaine Acetaminophen Injection Acephen An increased risk of methemoglobinemia Details Lidocaine Acetaminophen Rectal Acephen An increased risk of methemoglobinemia Details Lidocaine Acetazolamide Diamox® Sequels® An increased risk of methemoglobinemia Details Lidocaine Chloroprocaine An increased risk of local anesthetic toxicity and an increased risk methemoglobinemia Details Lidocaine Chloroquine Aralen® An increased risk of methemoglobinemia Details Lidocaine Cyclophosphamide Cytoxan® An increased risk of methemoglobinemia Details Lidocaine Cyclophosphamide Injection Cytoxan® Injection An increased risk of methemoglobinemia Details Lidocaine Dapsone Aczone An increased risk of methemoglobinemia Details Lidocaine Dapsone Topical Aczone An increased risk of methemoglobinemia Details Lidocaine Disopyramide Norpace An increased risk of cardiotoxicity Details Lidocaine Flecainide Tambocor® An increased risk of cardiotoxicity Details Lidocaine Flutamide Eulexin An increased risk of methemoglobinemia Details Lidocaine Furosemide Injection Disal An increased risk of methemoglobinemia Details Lidocaine Hydroxychloroquine Plaquenil An increased risk of seizures Details Lidocaine Hydroxyurea Droxia An increased risk of methemoglobinemia Details Lidocaine Ifosfamide Injection Ifex An increased risk of methemoglobinemia Details Lidocaine Isosorbide Dinitrate Isochron An increased risk of methemoglobinemia Details Lidocaine Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Lidocaine Metoclopramide Injection Gimoti An increased risk of methemoglobinemia Details Lidocaine Metoclopramide Nasal Spray Gimoti An increased risk of methemoglobinemia Details Lidocaine Mexiletine Mexitil® An increased risk of cardiotoxicity Details Lidocaine Nadolol Corgard Lidocaine toxicity (anxiety, myocardial depression, cardiac arrest) Details Lidocaine Nitrofurantoin Furadantin An increased risk of methemoglobinemia Details Lidocaine Nitroglycerin Gonitro An increased risk of methemoglobinemia Details Lidocaine Nitroglycerin Spray Nitrolingual An increased risk of methemoglobinemia Details Lidocaine Nitroglycerin Sublingual Nitrostat An increased risk of methemoglobinemia Details Lidocaine Nitroglycerin Topical Nitro-Bid An increased risk of methemoglobinemia Details Lidocaine Nitroglycerin Transdermal Patch Minitran® Patch An increased risk of methemoglobinemia Details

Moderate

Lidocaine Nevirapine Viramune Reduced lidocaine exposure Details Lidocaine Penbutolol Levatol® An increase in the volume of distribution and a prolongation of the elimination half-life of lidocaine Details

Minor

Lidocaine Clonidine Transdermal Patch Catapres Reduced lidocaine absorption following combined epidural administration Details

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