Yucca + Cobimetinib Fumarate
Cobimetinib Fumarate brand name: Cotellic.
We found no known interaction between Yucca and Cobimetinib Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Yucca and Cobimetinib Fumarate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Cobimetinib Fumarate and Yucca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Yucca at all — not against Cobimetinib Fumarate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Yucca safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Questions About Yucca or Cobimetinib Fumarate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Yucca or Cobimetinib Fumarate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Cobimetinib Fumarate
This page covers Yucca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobimetinib Fumarate page lists 138 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 94 moderate · 41 minor.
From our pharmacist’s overview on the Cobimetinib Fumarate page
“If you are on cobimetinib (Cotellic) for melanoma, be strict about supplements, because this list carries real weight. The drug is cleared by the liver enzyme CYP3A4, and nearly all 138 flagged ingredients can push its blood level up or down through that pathway.”
Reviewed by 2 · Jul 18, 2026
Taking Yucca as Part of a Dietary Supplement Product? Check It for Interactions
We hold 370 real supplement products containing Yucca, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yucca. Even though Yucca itself has no known interaction with Cobimetinib Fumarate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Yucca and Cobimetinib Fumarate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#394 of 1,452 supplements looked up here in the last 7 days
#373 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yucca reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yucca and Cobimetinib Fumarate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Yucca
What is Yucca?
- Joint pain and arthritis
- Digestive health
- High cholesterol
- Inflammation
- High blood pressure
Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for these uses is very limited, so it should not replace proven treatments. Talk to your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.
Yucca schidigera · Asparagaceae · Root, stem (trunk), and leaves · Capsules, tablets, powder, liquid extract, and tea
An interaction check asks whether these two react with each other — it does not ask whether Yucca is a good idea for someone in your situation. Here is what our Yucca record says about it on its own.
Yucca: dosing
There is no well-established standard dose for yucca supplements. Doses vary widely between products, and there is not enough research to recommend a specific amount.If you choose to try yucca, follow the directions on the product label and do not exceed them. A pharmacist or doctor can help you decide whether it is appropriate for you and review it against your other medications and health conditions.
From our Yucca monograph — the full record covers uses, side effects and every documented interaction.
About Cobimetinib
What Is Cobimetinib Used For?
Brand name: Cotellic
Cobimetinib is approved for two uses in adults. First, it is used in combination with another drug called vemurafenib to treat melanoma (a type of skin cancer) that cannot be surgically removed or has spread to other parts of the body — but only when the tumor carries a specific genetic change called a BRAF V600E or V600K mutation. A lab test must confirm this mutation before treatment begins.
Second, cobimetinib can be used on its own (as a single agent) to treat adults with histiocytic neoplasms — a rare group of cancers involving immune cells called histiocytes.
Other Drugs & Yucca
Browse every other medication we’ve checked against Yucca — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Yucca against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Ivermectin ›
- Testosterone ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Escitalopram ›
- Rivaroxaban ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Methamphetamine ›
- Tadalafil ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Amphetamine ›
- Bupropion ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Quetiapine ›
- Clonazepam ›
- Naproxen ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Yucca list.
Yucca References
The 3 references that drive our Yucca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- <p><span>Kanerva, L., Estlander, T., Petman, L., Makinen-Kiljunen, S. Occupational allergic contact urticaria to yucca (Yucca aloifolia), weeping fig (Ficus benjamina), and spathe flower (Spathiphyllum wallisii). Allergy. 2001;56(10): 1008-11.</span></p>
- Poljacki, M., Paravina, M., Jovanovic, M., Subotic, M., and Duran, V. [Contact allergic dermatitis caused by plants]. Med Pregl. 1993;46(9-10):371-375.
- Mahillon, V., Saussez, S., and Michel, O. High incidence of sensitization to ornamental plants in allergic rhinitis. Allergy 2006;61(9):1138-1140. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Yucca and Cobimetinib Fumarate Together: Common Questions
Is it safe to take Yucca with Cobimetinib Fumarate?
Does Cobimetinib Fumarate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Cobimetinib Fumarate and Yucca?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.