Yucca + Dihydroergotamine
Dihydroergotamine brand names: Migranal, DHE-45.
We found no known interaction between Yucca and Dihydroergotamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Yucca and Dihydroergotamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dihydroergotamine and Yucca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Yucca at all — not against Dihydroergotamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Yucca safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Dihydroergotamine Is Prescribed For, and What Yucca Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Dihydroergotamine is a prescription medicine with approved uses on its FDA label. Yucca is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Dihydroergotamine is prescribed for: Dihydroergotamine injection is used to stop a migraine headache once it has started — with or without the visual or sensory warning signs known as aura. It is also used to treat cluster headaches in adults. It is not used to prevent migraines from happening, and it is not for hemiplegic migraine (migraine that causes temporary paralysis) or migraine with brainstem aura. Brekiya is specifically approved for subcutaneous (under-the-skin) self-injection using an autoinjector device.
Yucca has been studied for:
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Migraine headache studied, not established Yucca has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Yucca for migraine headache
Although there has been interest in using oral yucca for migraine headache, there is insufficient reliable information about the clinical effects of yucca for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dihydroergotamine on your own; if you are taking Yucca for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Dihydroergotamine
This page covers Yucca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dihydroergotamine page lists 156 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).
By severity: 4 major · 110 moderate · 42 minor.
From our pharmacist’s overview on the Dihydroergotamine page
“Dihydroergotamine (Migranal, DHE-45) stops migraines by tightening blood vessels, and this interaction list deserves genuine care. Four of its 156 supplement interactions rate major, and the largest theme, covering 121 ingredients, involves the CYP3A4 enzyme that clears the drug.”
Reviewed by 2 · Jul 18, 2026
Taking Yucca as Part of a Dietary Supplement Product? Check It for Interactions
We hold 370 real supplement products containing Yucca, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yucca. Even though Yucca itself has no known interaction with Dihydroergotamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Yucca and Dihydroergotamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#393 of 1,452 supplements looked up here in the last 7 days
#2,639 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yucca reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Yucca and Dihydroergotamine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Yucca
What is Yucca?
- Joint pain and arthritis
- Digestive health
- High cholesterol
- Inflammation
- High blood pressure
Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for these uses is very limited, so it should not replace proven treatments. Talk to your pharmacist or doctor before trying it, especially if you are pregnant, breastfeeding, or take other medicines.
Yucca schidigera · Asparagaceae · Root, stem (trunk), and leaves · Capsules, tablets, powder, liquid extract, and tea
An interaction check asks whether these two react with each other — it does not ask whether Yucca is a good idea for someone in your situation. Here is what our Yucca record says about it on its own.
Yucca: dosing
There is no well-established standard dose for yucca supplements. Doses vary widely between products, and there is not enough research to recommend a specific amount.If you choose to try yucca, follow the directions on the product label and do not exceed them. A pharmacist or doctor can help you decide whether it is appropriate for you and review it against your other medications and health conditions.
From our Yucca monograph — the full record covers uses, side effects and every documented interaction.
About Dihydroergotamine Injection
What Is Dihydroergotamine Injection Used For?
Brand names: Migranal, DHE-45
Dihydroergotamine injection is used to stop a migraine headache once it has started — with or without the visual or sensory warning signs known as aura. It is also used to treat cluster headaches in adults.
It is not used to prevent migraines from happening, and it is not for hemiplegic migraine (migraine that causes temporary paralysis) or migraine with brainstem aura. Brekiya is specifically approved for subcutaneous (under-the-skin) self-injection using an autoinjector device.
Most-Reported Side Effects for Dihydroergotamine
From FAERS, the FDA’s public side-effect reporting system (1,268 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Yucca
Browse every other medication we’ve checked against Yucca — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Yucca against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Yucca list.
Yucca References
The 3 references that drive our Yucca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- <p><span>Kanerva, L., Estlander, T., Petman, L., Makinen-Kiljunen, S. Occupational allergic contact urticaria to yucca (Yucca aloifolia), weeping fig (Ficus benjamina), and spathe flower (Spathiphyllum wallisii). Allergy. 2001;56(10): 1008-11.</span></p>
- Poljacki, M., Paravina, M., Jovanovic, M., Subotic, M., and Duran, V. [Contact allergic dermatitis caused by plants]. Med Pregl. 1993;46(9-10):371-375.
- Mahillon, V., Saussez, S., and Michel, O. High incidence of sensitization to ornamental plants in allergic rhinitis. Allergy 2006;61(9):1138-1140. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Yucca and Dihydroergotamine Together: Common Questions
Is it safe to take Yucca with Dihydroergotamine?
Are Yucca and Dihydroergotamine used for the same thing?
Does Dihydroergotamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.