Herb & supplement monograph

Cardamom Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Cardamom

0 medications have a known interaction with Cardamom, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Cardamom. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Cardamom combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Cardamom: Uses, Safety & Side Effects

The bottom line

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements have not been well studied, so the health benefits remain mostly unproven. If you want to use concentrated cardamom products, check with your pharmacist or doctor first.

Scientific name
Elettaria cardamomum
Family
Zingiberaceae
Part used
Seeds (from the dried fruit pods) and essential oil
Common forms
Whole pods, ground spice, tea, capsules, extracts, and essential oil
People commonly use it for
  • Digestive upset and bloating
  • Bad breath
  • Nausea
  • Flavoring in food and drinks
  • General antioxidant support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLikely safe

Amounts used in food are generally well tolerated by most people.

PregnancyUse caution

Food amounts are likely fine, but avoid concentrated supplement or essential oil doses without medical advice.

BreastfeedingLikely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of cardamom when used in me...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Cardamom is a warm, aromatic spice that comes from the seeds of plants in the ginger family. The most common type, often called green or true cardamom, comes from a plant called Elettaria cardamomum. It grows mainly in India, Sri Lanka, Guatemala, and other warm regions.

People around the world use cardamom to flavor foods, curries, baked goods, coffee, and tea. In traditional medicine systems such as Ayurveda, it has been used for hundreds of years to help with digestion, freshen the breath, and ease stomach discomfort. Today you can find it as whole pods, ground powder, teas, capsules, and essential oil.

How it works

Cardamom contains aromatic plant compounds, including an essential oil rich in substances such as cineole and terpinyl acetate. It also has antioxidant compounds that may help reduce damage from unstable molecules called free radicals.

In laboratory research, cardamom extracts have shown antioxidant, anti-inflammatory, and antimicrobial activity. Some animal studies suggest it may relax muscles in the gut, which could explain its traditional use for digestion. Keep in mind that effects seen in a test tube or in animals do not always carry over to people.

Effectiveness

Does Cardamom work?

Evidence overview · 12 uses evaluated
12 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Cardamom, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 12 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral cardamom may slightly reduce glycated hemoglobin (HbA1c) in patients with type 2 diabetes, but it does not appear to improve blood glucose, blood pressure, or cholesterol levels in these patients.

Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral cardamom for dyspepsia, there is insufficient reliable information about the clinical effects of cardamom for this purpose.

Insufficient Reliable Evidence To Rate Epilepsy
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral cardamom essential oil for epilepsy, there is insufficient reliable information about the clinical effects of cardamom for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that oral cardamom may modestly reduce triglyceride levels in patients with hyperlipidemia, but it does not seem to improve other lipid levels in these patients.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral cardamom powder is beneficial in patients with hypertension.

Insufficient Reliable Evidence To Rate Irritable bowel syndrome (IBS)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral cardamom for IBS, there is insufficient reliable information about the clinical effects of cardamom for this purpose.

Insufficient Reliable Evidence To Rate Nonalcoholic fatty liver disease (NAFLD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral cardamom is beneficial in patients with NAFLD.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral cardamom is beneficial in patients with diabetes.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral cardamom powder is beneficial in patients with PCOS.

Insufficient Reliable Evidence To Rate Postoperative nausea and vomiting (PONV)
Rating & evidence shown verbatim from Natural Medicines

Aromatherapy with cardamom essential oil has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Pregnancy-induced nausea and vomiting
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral cardamom for pregnancy-induced nausea and vomiting, there is insufficient reliable information about the clinical effects of cardamom for this purpose.

Insufficient Reliable Evidence To Rate Respiratory tract infections
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral cardamom for various respiratory tract infections, including bronchitis, influenza, and the common cold, there is insufficient reliable information about the clinical effects of cardamom for these conditions.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Cardamom used as a spice in normal food amounts is considered safe for most people. The bigger unknown is concentrated supplements, extracts, and essential oils, which have not been well studied for safety at high doses.

People with a known allergy to cardamom or related plants should avoid it. If you have gallstones, talk to your doctor before using medicinal amounts, since some sources advise caution.

Pregnancy: Eating cardamom in food is likely fine, but there is not enough safety information on large medicinal doses, so it is best to avoid concentrated products during pregnancy unless your doctor approves.

Breastfeeding: Food amounts are likely fine, but the safety of supplement-strength doses while breastfeeding is unknown, so caution is advised.

Essential oil: Cardamom essential oil should never be swallowed unless directed by a qualified professional, as concentrated oils can be harmful.

Side effects

When used in food amounts, cardamom rarely causes problems. Some people may have mild stomach upset.

Allergic reactions are possible but uncommon. Signs can include skin rash, itching, swelling, or trouble breathing. If you have any of these symptoms, stop using it and seek medical care right away. Concentrated supplements and essential oils carry a higher risk of irritation or unexpected effects because they are much stronger than the spice.

Cardamom: Reported Adverse Effects

Documented safety reports on Cardamom from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Dermatitis Dermatologic

Orally, mild skin inflammation due to cardamom has been reported in one participant of a clinical trial. Topically, a case report describes chronic hand dermatitis in a confectioner frequently exposed to cardamom. Skin patch tests were positive for cardamom, and for terpenoids present in the seeds.

  1. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri
  2. Mobacken, H. and Fregert, S. Allergic contact dermatitis from cardamom. Contact Dermatitis 1975;1(3):175-176.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized medicinal dose for cardamom. As a spice, people use it freely in cooking, which is considered safe.

For supplements, capsules, or extracts, the right amount varies by product, and a proven effective dose has not been established. The safest approach is to follow the directions on the product label and not exceed them. Because product strengths differ, it is a good idea to check with your pharmacist or doctor before starting any concentrated cardamom product, especially if you are pregnant, breastfeeding, or have a health condition.

Pregnancy & Breastfeeding

Cardamom & Breastfeeding

Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of cardamom when used in medicinal amounts. Avoid using amounts greater than those used in food.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Cardamom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mobacken, H. and Fregert, S. Allergic contact dermatitis from cardamom. Contact Dermatitis 1975;1(3):175-176. PubMed
  2. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agri PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Cardamom

873 products in our database contain Cardamom. Open any to see its full ingredient list and every drug interaction we check.

Bitters Extra by Vitanica Capsule 90 Vegetarian Capsule(s) View ingredients & interactions Botanical Blends Warming Vanilla by Traditional Medicinals Other (e.g. Tea Bag) 0.86 Ounce(s) · 24.5 Gram(s) · 14 Wrapped Tea Bag(s) View ingredients & interactions Brahmi Rasayana 15b by Ayurvedic Rasayanas Other (e.g. Tea Bag) 10.7 Ounce(s) · 300 Gram(s) View ingredients & interactions Brain Chai Latte by Simply Young Powder 150 Gram(s) · 5.29 Ounce(s) View ingredients & interactions Breathe Deep by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 1.12 Oz(s) · 32 Gram(s) View ingredients & interactions Bronchial Formula by Nature's Sunshine Capsule 100 Capsule(s) View ingredients & interactions Bronchial Formula by Nature's Sunshine Capsule 60 Packet(s) · 330 Capsule(s) View ingredients & interactions Calm Natural Vanilla Chai Flavor by BareOrganics Other (e.g. Tea Bag) 1.15 Ounce(s) · 32.5 Gram(s) View ingredients & interactions Calm Natural Vanilla Chai Flavor by BareOrganics Other (e.g. Tea Bag) 2.76 Ounce(s) · 78 Gram(s) View ingredients & interactions Calming by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 1.02 Oz(s) · 29 Gram(s) View ingredients & interactions Cao Guo by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Cao Guo by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Cao Guo by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Cao Guo by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Cao Guo Alcohol Free by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Cao Guo Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Caramel Apple Spice Slim Life by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 32 Gram(s) · 1.12 Ounce(s) View ingredients & interactions Caramel Apple Spice Slim Life by Yogi Other (e.g. Tea Bag) 16 Tea Bag(s) · 1.12 Oz(s) · 32 Gram(s) View ingredients & interactions Cardamom by Revive Liquid 10 mL View ingredients & interactions Cardamom by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Cardamom by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Cardamom by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Cardamom by NusaPure Capsule 200 Veg Cap(s) View ingredients & interactions Cardamom by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions
Pharmacist Counseling Corner

Cardamom: Common Questions

What is Cardamom used for, and does it work?
People use Cardamom for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Cardamom interact with prescription medications?
We do not currently list any known drug interactions for Cardamom. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Cardamom interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Cardamom with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Cardamom interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Cardamom used for?
It is mainly used as a cooking spice, and traditionally for digestion, bloating, nausea, and freshening the breath. Most of these uses are based on tradition rather than strong scientific proof.
Is Cardamom safe to eat every day?
Using Cardamom as a spice in normal food amounts is generally safe for most people. Concentrated supplements are less studied, so talk to your pharmacist before taking large daily doses.
Can I take Cardamom while pregnant or breastfeeding?
Cardamom in food is likely fine, but it is best to avoid concentrated supplements or essential oils during pregnancy and breastfeeding unless your doctor says it is okay.
Does chewing Cardamom really help bad breath?
Chewing Cardamom seeds is a long-standing folk remedy for fresh breath, and some lab studies suggest it may fight certain mouth bacteria, but solid human evidence is limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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