Chickweed Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Chickweed interacts with medications. The heart of this page is the interaction list — every drug Chickweed is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Chickweed is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Chickweed against your medication
Add one medicationDrugs that interact with Chickweed
0 medications have a known interaction with Chickweed, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Chickweed. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Chickweed combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Chickweed: Uses, Safety & Side Effects
Chickweed is a common edible wild plant traditionally used on the skin for itching and minor irritation, and taken as a tea or tincture for various complaints. Solid human studies are lacking, so its benefits are largely based on tradition rather than proof. It is generally considered low-risk when used short-term, but pregnant and breastfeeding people should avoid it due to limited safety data.

- Scientific name
- Stellaria media
- Family
- Caryophyllaceae
- Part used
- Above-ground parts (leaves, stems, and flowers)
- Common forms
- Tea, capsules, tincture, dried herb, creams, ointments, salves, poultices
- Skin irritation and itching
- Minor wounds and cuts
- Digestive upset
- Joint and muscle aches
- Used historically for scurvy
- Mild diuretic
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally considered low-risk for short-term use, but high-quality safety data are limited.
When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used...
Read the full pregnancy detailWhen used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Chickweed (Stellaria media) is a small, low-growing plant with weak, sprawling stems and tiny white, star-shaped flowers. It grows almost everywhere as a common weed in gardens, lawns, fields, and along roadsides across much of the world.
People have eaten the tender leaves and stems in salads and soups for centuries, and it has long been used in folk medicine. It is most often applied to the skin in creams, ointments, and poultices for itching and irritation, or taken by mouth as a tea or tincture.
How it works
Chickweed contains a mix of plant compounds, including saponins, flavonoids, vitamin C, and other antioxidants. These compounds are sometimes credited with soothing, anti-inflammatory, and mild wound-supporting effects.
It is important to know that most of these effects have only been observed in laboratory or test-tube studies. How well these compounds work in the human body, and at what amounts, has not been clearly proven.
Does Chickweed work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Chickweed, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Diabetes
Although there has been interest in using oral chickweed for diabetes, there is insufficient reliable information about the clinical effects of chickweed for this purpose.
Insufficient Reliable Evidence To Rate Hyperlipidemia
Although there has been interest in using oral chickweed for hyperlipidemia, there is insufficient reliable information about the clinical effects of chickweed for this purpose.
Insufficient Reliable Evidence To Rate Obesity
Although there has been interest in using oral chickweed for obesity, there is insufficient reliable information about the clinical effects of chickweed for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Chickweed is eaten as a food and is generally thought to be low-risk when used in small amounts for a short time. Still, there are no good long-term safety studies in people.
Be careful not to confuse chickweed with similar-looking plants, since misidentified wild plants can be harmful. People with plant or pollen allergies may react to it. Because chickweed contains saponins, large amounts taken by mouth could cause stomach upset.
Pregnancy and breastfeeding: There is not enough reliable information to know whether chickweed is safe during pregnancy or while breastfeeding. To be safe, avoid it during these times. Always check with your pharmacist or doctor before using chickweed, especially if you have a health condition or take other medicines.
Side effects
When used on the skin or eaten in small food amounts, chickweed is usually well tolerated. Possible side effects include skin irritation or an allergic reaction in sensitive people.
Taken by mouth in large amounts, the saponins in chickweed may cause nausea, stomach upset, diarrhea, or vomiting. Stop using it and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.
Chickweed: Reported Adverse Effects
Documented safety reports on Chickweed from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionDermatitis Immunologic
Topically, chickweed extract has been reported to cause contact dermatitis.
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25.
- Jovanovic, M., Poljacki, M., Mimica-Dukic, N., Boza, P., Vujanovic, Lj, Duran, V., and Stojanovic, S. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-alle
- Poljacki, M., Jovanovic, M., Boza, P., Mimica-Dukic, N., Petrovic, A., and Novovic, Z. [Is Vojvodina a risk area for contact weed allergies?]. Med Pregl. 2005;58(3-4):123-126.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established, standardized dose for chickweed. It is sold in many forms, including teas, tinctures, capsules, and skin creams or ointments, and the strength varies widely between products.
If you use a commercial product, follow the directions on the label. Because a proven safe and effective dose has not been set, it is best to start low and check with your pharmacist or doctor before using it, especially by mouth.
Chickweed & Pregnancy
Chickweed & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 4 references that drive our Chickweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
- Jovanovic, M., Poljacki, M., Mimica-Dukic, N., Boza, P., Vujanovic, Lj, Duran, V., and Stojanovic, S. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-alle
- Poljacki, M., Jovanovic, M., Boza, P., Mimica-Dukic, N., Petrovic, A., and Novovic, Z. [Is Vojvodina a risk area for contact weed allergies?]. Med Pregl. 2005;58(3-4):123-126. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Chickweed
59 brands in our database make a supplement containing Chickweed.
Supplement products with Chickweed
277 products in our database contain Chickweed. Open any to see its full ingredient list and every drug interaction we check.
Chickweed: Common Questions
What is Chickweed used for, and does it work?
Does Chickweed interact with prescription medications?
How are Chickweed interactions rated?
Is it safe to take Chickweed with my medications?
Where does this Chickweed interaction information come from?
What is Chickweed used for?
Is Chickweed safe to eat?
Can I use Chickweed if I am pregnant or breastfeeding?
Does Chickweed cause side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Chickweed
A rotating sample of real supplements in our database that list Chickweed — open any to see its full ingredients and every drug interaction we check.
- Kidneys & Bladder 4 Tincture by Dr. Morse's Cellular Botanicals
- Fat Grabbers by Nature's Sunshine
- Skin Bone Repair by Earth Friend Herb Co.
- Kidneys & Bladder 2 Glycerin by Dr. Morse's Cellular Botanicals
- Chickweed by L.A. Naturals
- Total Body Purifier by Cellular Research Formulas
- Sym by Loomis Enzymes
- GI Renew (1 - Normal) Capsules by Dr. Morse's Cellular Botanicals
- Chickweed Leaf Powder by TerraVita Premium Collection
- Multi-Herb Digestion & Detox Support by Nature's Secret
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