Herb & supplement monograph

Indium Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Indium

0 medications have a known interaction with Indium, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Indium. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Indium combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Indium: Uses, Safety & Side Effects

The bottom line

Indium is a metallic chemical element sometimes sold as a liquid 'trace mineral' supplement with bold anti-aging and energy claims, but it is not a recognized essential nutrient and there is no reliable human evidence that it offers any health benefit. Because safety data are very limited and it is a heavy metal, most people should avoid it and talk with a pharmacist or doctor first.

Part used
Not a plant; a chemical element (indium) sold as a mineral supplement
Common forms
Liquid 'indium sulfate' drops, sometimes capsules
People commonly use it for
  • Anti-aging
  • Boosting energy
  • Supporting hormone or gland function
  • General 'wellness' or trace mineral supplementation

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

Indium is not an essential nutrient and lacks reliable human safety or benefit data.

PregnancyPossibly Unsafe

When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many...

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Indium is a soft, silvery metallic chemical element (symbol In). It is not an herb or a plant; it is a metal mostly used in industry, such as in electronics, screens, and solders. It is found in tiny amounts in the earth, often alongside zinc ores.

In the supplement world, indium is usually sold as a liquid mineral product, often labeled as 'indium sulfate.' Marketers promote it as a 'master mineral' or trace element. These products are sold online and in some health stores, often with strong promises about energy, aging, and hormone balance.

It is important to know that indium is not considered an essential nutrient. Your body does not require indium to function, and the marketing claims around it are not backed by solid science.

How it works

Sellers sometimes claim that indium acts on the hypothalamus and pituitary glands to 'balance' hormones, or that it helps the body absorb other minerals. These ideas are not supported by good scientific evidence.

There is no established biological role for indium in the human body, and no proven mechanism by which a supplement form would produce the benefits that are advertised. Any explanations you see are largely theoretical or promotional, not based on solid laboratory or clinical data.

Effectiveness

Does Indium work?

Evidence overview · 1 use evaluated
1 Effective
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Effective Cancer diagnosis
Rating & evidence shown verbatim from Natural Medicines

Indium (In-111) pentetreotide injection (OctreoScan) is an FDA-approved prescription product for use in diagnosing primary and metastatic neuroendocrine tumors bearing somatostatin receptors.

Sources Ref 102824

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Indium is a heavy metal, and its long-term safety as a supplement has not been well studied in people. Workplace studies in industries that handle indium compounds have raised concerns about lung problems with inhalation, which is a different exposure than swallowing a supplement, but it shows the body does not handle this metal as a harmless nutrient.

Because there is no clear safe dose and no proven benefit, most people are best off avoiding indium supplements. Children, people with kidney or liver disease, and anyone with a chronic health condition should not use it without medical guidance.

For pregnancy and breastfeeding, there is no safety information, so it should be avoided. When in doubt, talk with your pharmacist or doctor before taking any product containing indium.

Side effects

Because indium supplements have not been carefully studied, the full range of possible side effects is unknown. Some users report a metallic taste or stomach upset.

As a heavy metal, there is a theoretical concern about buildup in the body and possible harm to organs such as the kidneys or liver with regular use. If you take indium and notice any new symptoms—such as nausea, fatigue, or changes in urination—stop using it and seek medical advice.

Indium: Reported Adverse Effects

Documented safety reports on Indium from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Chronic obstructive pulmonary disease (COPD) Pulmonary/Respiratory

Occupational exposure to indium by inhalation can lead to potentially fatal interstitial lung disease, characterized by pulmonary alveolar proteinosis, progressing to fibrosis with or without emphysema. The disease develops slowly with shortness of breath, chest tightness and pain, dry cough, dyspnea, and deteriorating pulmonary function tests. Abnormalities seen with high-resolution computed tomography include subpleural honeycomb, diffuse centrilobular emphysema, and diffuse reticulonodular infiltration. Serum indium levels are elevated, and severity is linked to the level and duration of exposure. Once exposure stops, accumulated indium clears extremely slowly from the lungs and the disease may not be reversible.

  1. Tsao YC, Fan HY, Luo JJ. Case reports of indium lung disease in Taiwan. J Formos Med Assoc. 2021 Feb;120(2):893-8.
  2. Yang J, Zhang W, Feng J. Low serum indium levels induce expression disorders of some inflammatory factors. Int Arch Occup Environ Health. 2021 Jan;94(1):23-30.
Skin irritation Dermatologic

Topically, indium can cause skin irritation.

  1. Indium. Material Safety Data Sheet. Science Lab, October 2005.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or recommended dose for indium, because it is not an essential nutrient and has no proven benefit. Products that contain it are not standardized, and label amounts vary.

We do not recommend a specific dose. If you are considering a product that contains indium, read the label carefully and check with a pharmacist or doctor first. In general, the safest choice is to avoid it.

Pregnancy & Breastfeeding

Indium & Pregnancy

Possibly Unsafe

When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many organ systems; avoid using. ...when indium (In-111) pentetreotide is used intravenously. It is not known if it can harm the fetus, or if it is excreted in breast milk.

  1. Miyaki K, Hosoda K, Hirata M, et al. Biological monitoring of indium by means of graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds. J Occup Health 2003;45:228-30.
  2. Indium. Material Safety Data Sheet. Science Lab, October 2005.
  3. Indium In-111 pentetreotide injection (OctreoScan) Package Insert. Curium US LLC, Maryland Heights, MO. 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=93d8f3b2-1216-41dc-a63d-0e812b33891d. Accessed April 25, 2020.

Indium & Breastfeeding

Possibly Unsafe

When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many organ systems; avoid using. ...when indium (In-111) pentetreotide is used intravenously. It is not known if it can harm the fetus, or if it is excreted in breast milk.

  1. Miyaki K, Hosoda K, Hirata M, et al. Biological monitoring of indium by means of graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds. J Occup Health 2003;45:228-30.
  2. Indium. Material Safety Data Sheet. Science Lab, October 2005.
  3. Indium In-111 pentetreotide injection (OctreoScan) Package Insert. Curium US LLC, Maryland Heights, MO. 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=93d8f3b2-1216-41dc-a63d-0e812b33891d. Accessed April 25, 2020.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 5 references that drive our Indium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Miyaki K, Hosoda K, Hirata M, et al. Biological monitoring of indium by means of graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds. J Occup Health 2003;45:228-30. PubMed
  2. Indium. Material Safety Data Sheet. Science Lab, October 2005.
  3. Indium In-111 pentetreotide injection (OctreoScan) Package Insert. Curium US LLC, Maryland Heights, MO. 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=93d8f3b2-1216-41dc-a63d-0e812b33891d. Accessed April 25, 2020.
  4. Tsao YC, Fan HY, Luo JJ. Case reports of indium lung disease in Taiwan. J Formos Med Assoc. 2021 Feb;120(2):893-8. PubMed
  5. Yang J, Zhang W, Feng J. Low serum indium levels induce expression disorders of some inflammatory factors. Int Arch Occup Environ Health. 2021 Jan;94(1):23-30. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Indium

55 products in our database contain Indium. Open any to see its full ingredient list and every drug interaction we check.

Nature's Optimal Nutrition Energize Peach Mango by Health Direct Liquid 30 Fluid Ounce(s) · 887 mL View ingredients & interactions ORME Oxygen+ by Ambaya Gold Liquid 1 oz. View ingredients & interactions Pure Colloidal Minerals by Buried Treasure Liquid Nutrients Liquid 32 fl. Oz. · 946 mL View ingredients & interactions RNA Spray by Complete Ascentials Liquid 1 Ounce(s) View ingredients & interactions Silver Immune Shield by Sunwarrior Liquid 236.5 mL · 8 fl. Oz. View ingredients & interactions Step 1 Ion Booster by pHion Balance Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Supreme Liquid Multivitamin Tropical Fruit Flavor by Optim Nutrition Liquid 32 fl. Oz. · 946 mL View ingredients & interactions Trace Min by Douglas Laboratories Capsule 100 Capsule(s) View ingredients & interactions Trace Minerals by Zemvelo Liquid 16.2 fl. Oz. · 480 mL View ingredients & interactions Trace-Mins by NaturesPlus Tablet Or Pill 180 Tablet(s) View ingredients & interactions Ultimate Indium Concentrate by Complete H2O Minerals Liquid 2 Oz(s) · 60 mL View ingredients & interactions Uplift by Organa Crystalline Nano Liquid 16 Fluid Ounce(s) · 1 Pint(s) · 470 Milliliter(s) View ingredients & interactions Uplift by Organa Liquid 32 Fluid Ounce(s) · 1 Quart(s) · 940 Milliliter(s) View ingredients & interactions Vegan Nightime Multi-Vitamin by Tropical Oasis Liquid 32 Fluid Ounce(s) · 960 Milliliter(s) View ingredients & interactions VitaComplete by Vitabase Liquid 32 fl. Oz. View ingredients & interactions All In One Plus Cranberry Aloe Vera Flavor by Tropical Oasis Liquid 16 oz. · 480 mL Off market View ingredients & interactions Beyond Tangy Tangerine by Youngevity Powder 420 Gram(s) Off market View ingredients & interactions ConcenTrace Trace Mineral Tablets by Trace Minerals Research Tablet Or Pill 90 Tablet(s) Off market View ingredients & interactions Concord Grape by Buried Treasure Liquid Nutrients Liquid 32 fl. Oz. · 946 mL Off market View ingredients & interactions Essence of Life by Ambaya Gold Liquid 32 oz. Off market View ingredients & interactions Fulvic Green by Ambaya Gold Liquid 16 oz. Off market View ingredients & interactions Grape Colloidal Minerals by Buried Treasure Liquid Nutrients Liquid 32 fl. Oz. · 946 mL Off market View ingredients & interactions intraKID All-In-One All Natural Fresh Raspberry Taste by Drucker Labs Liquid 32 fl. Oz. · 946 mL Off market View ingredients & interactions Ionic Minerals by Nature's Sunshine Liquid 32 fl. Oz. · 946 mL Off market View ingredients & interactions
Pharmacist Counseling Corner

Indium: Common Questions

What is Indium used for, and does it work?
People use Indium for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Indium for Cancer diagnosis. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Indium interact with prescription medications?
We do not currently list any known drug interactions for Indium. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Indium interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Indium with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Indium interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Indium used for?
It is marketed as an anti-aging, energy, and 'trace mineral' supplement, but there is no reliable human evidence that it works for any of these uses.
Is Indium an essential nutrient?
No. Your body does not need Indium to function, and it is not recognized as a vitamin, mineral, or essential trace element.
Is Indium safe to take?
Its safety has not been well studied in people, and because it is a heavy metal with no proven benefit, most people should avoid it and talk with a healthcare professional first.
Can I take Indium while pregnant or breastfeeding?
No. There is no safety data for Indium during pregnancy or breastfeeding, so it should be avoided.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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