Herb & supplement monograph

Lactic Acid Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Lactic Acid interacts with medications. The heart of this page is the interaction list — every drug Lactic Acid is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Lactic Acid is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

Check Lactic Acid against your medication

Add one medication
Lactic Acid
+
Start typing any prescription or over-the-counter drug name.
Reviewed by licensed pharmacists Sourced from Natural Medicines
On this page
Interaction report

Drugs that interact with Lactic Acid

0 medications have a known interaction with Lactic Acid, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Lactic Acid. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Lactic Acid combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Lactic Acid: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Lactic acid is a naturally occurring acid made by the body during exercise and by bacteria that ferment milk and other foods. It is most often used on the skin as an exfoliant and moisturizer and in some vaginal products to support normal pH. While topical skin uses are well established, evidence for swallowing lactic acid supplements for health benefits is limited, so check with a pharmacist before using it.

Common forms
Topical creams and lotions, chemical peels, oral capsules, foods (fermented dairy), suppositories, mouth rinses
People commonly use it for
  • Skin exfoliation and anti-aging
  • Moisturizing dry skin
  • Maintaining vaginal pH
  • Acne and skin texture
  • Ingredient in fermented foods

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe in foods and skin products, but strong concentrations can irritate skin and mucous membranes.

PregnancyLikely Safe

When used topically in appropriate concentrations . There is insufficient reliable information available about the safety of lactic acid when used ora...

Read the full pregnancy detail
BreastfeedingLikely Safe

When used topically in appropriate concentrations . There is insufficient reliable information available about the safety of lactic acid when used ora...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Lactic acid is a natural acid that the body makes in muscles during hard exercise and that bacteria make when they ferment sugars. It is the substance that gives sour milk, yogurt, sauerkraut, and sourdough bread their tangy taste.

In supplements and consumer products, lactic acid is usually made by fermenting carbohydrates like corn or beets with bacteria. It is one of a group of compounds called alpha hydroxy acids (AHAs) that are widely used in skin care.

People most commonly meet lactic acid in skin creams, peels, and moisturizers, in some vaginal health products, and as a natural part of fermented foods. It is also used as a food preservative and flavoring.

How it works

On the skin, lactic acid works as an alpha hydroxy acid. It loosens the bonds that hold dead skin cells together, helping them shed so newer, smoother skin shows. It also draws and holds water, which helps the skin feel more hydrated.

In the vagina and gut, lactic acid is produced by helpful Lactobacillus bacteria and lowers the pH, creating an acidic environment that may make it harder for some unwanted microbes to grow.

Much of the detailed understanding of these effects comes from laboratory studies and skin research. The way lactic acid behaves can depend a lot on its concentration and the pH of the product.

Effectiveness

Does Lactic Acid work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 10 uses evaluated
1 Likely effective 9 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Likely Effective Dry skin
Rating & evidence shown verbatim from Natural Medicines

Topical lactic acid, as lactate, lactic acid, or ammonium lactate, improves the severity of dry skin.

Also studied for 9 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Topical lactic acid has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

Preliminary clinical research shows that topical lactic acid seems to reduce wrinkles and other signs of aging and photodamage.

Insufficient Reliable Evidence To Rate Bacterial vaginosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravaginal lactic acid is beneficial for bacterial vaginosis.

Insufficient Reliable Evidence To Rate Canker sores
Rating & evidence shown verbatim from Natural Medicines

It is unclear if a mouthwash containing lactic acid is beneficial for canker sores.

Insufficient Reliable Evidence To Rate Melasma
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical lactic acid is beneficial for melasma.

Insufficient Reliable Evidence To Rate Onychomycosis
Rating & evidence shown verbatim from Natural Medicines

Topical lactic acid has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Seborrheic dermatitis
Rating & evidence shown verbatim from Natural Medicines

Topical lactic acid has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Urinary tract infections (UTIs)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravaginal lactic acid is beneficial for UTI prevention.

Insufficient Reliable Evidence To Rate Water warts
Rating & evidence shown verbatim from Natural Medicines

Topical lactic acid has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Lactic acid is a normal part of the body and of many foods, so eating it in foods like yogurt is considered safe for most people. As a skin product, it is generally well tolerated when used as directed.

Stronger concentrations, such as professional peels, can cause irritation, burning, and increased sensitivity to the sun. People with sensitive skin or skin conditions should be cautious and may want to test a small area first.

Pregnancy and breastfeeding: Lactic acid in normal food amounts is generally considered fine. However, the safety of concentrated skin peels or vaginal products has not been well studied in these groups, so it is best to check with your doctor or pharmacist before using them.

If you have any chronic medical condition or use prescription skin treatments, talk to a healthcare professional before adding lactic acid products.

Side effects

On the skin, lactic acid can cause redness, stinging, burning, itching, dryness, or peeling, especially at higher strengths or with frequent use. It can also make your skin more sensitive to sunlight, so daily sunscreen is recommended.

Vaginal products may cause mild irritation in some people. Eating foods with lactic acid rarely causes problems beyond their normal taste.

Serious reactions are uncommon, but stop using a product and seek care if you develop severe burning, blistering, swelling, or signs of an allergic reaction.

Lactic Acid: Reported Adverse Effects

Documented safety reports on Lactic Acid from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Topically, intravaginally, and as a mouthwash, lactic acid is generally well tolerated.

Most Common Adverse Effects:

Topically: Mild irritation, sun sensitivity, and a tingling sensation.

Serious Adverse Effects (Rare):

Topically: Increased risk of skin cancer, skin damage, and transient hyperpigmentation. With the use of higher concentrations, bleeding, blistering, burns, itching, redness, severe irritation, and skin discoloration with sloughing, stinging, and swelling.

Reports by condition
Burns Dermatologic

Topically, lactic acid is generally well tolerated when used in concentrations at or below 10% and applied to the face or 15% and applied elsewhere. In general, products should be tested on a small area of skin before applying it to a larger area.

Alpha hydroxy acids like lactic acid can increase sensitivity to the sun and ultraviolet (UV) light. This can increase damage to the skin, and after long-term use, might increase the risk of skin cancer. These effects can be mitigated by using sunscreen and/or protective clothing.

Adverse reactions to alpha hydroxy acids like lactic acid can range from mild irritation, a tingling sensation, and stinging, to severe redness, swelling, itching, blistering, bleeding, rash, burns, and skin discoloration.

Nail discoloration, nail detachment, and nail softness, as well as irritation, pain, and redness at the application site were reported in a clinical trial investigating the topical use of a specific nail product (K101) containing lactic acid, urea, and propylene glycol. It is unclear if these effects are due to lactic acid, other ingredients, or the combination.

  1. Kempers S, Katz HI, Wildnauer R, Green B. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 1998;61:347-50.
  2. Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6.
  3. Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986;37:205-7, 209.
  4. Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989;21(4 Pt 1):714-6.
  5. Jennings MB, Logan L, Alfieri DM, Ross CF, Goodwin S, Lesczczynski C. A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. J Am Podiatr Med Assoc 2002;92(3):143-8.
  6. Dahl MV, Dahl AC. 12% lactate lotion for the treatment of xerosis. A double-blind clinical evaluation. Arch Dermatol 1983;119(1):27-30.
  7. Pham HT, Exelbert L, Segal-Owens AC, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48(5):30-6.
  8. Draelos ZD, Hall S, Munsick C. A 14-day Controlled Study Assessing Qualitative Improvement with 15% Lactic Acid and Ceramides in Skin Moisturization and Desquamation. J Clin Aesthet Dermatol 2020;13(8):E54-E58.
  9. Jennings MB, Alfieri D, Ward K, Lesczczynski C. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc 1998;88(7):332-6.
  10. Ademola J, Frazier C, Kim SJ, Theaux C, Saudez X. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol 2002;3(3):217-22.
  11. Jennings MB, Alfieri DM, Parker ER, Jackman L, Goodwin S, Lesczczynski C. A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. Cutis 2003;71
  12. Uy JJ, Joyce AM, Nelson JP, West B, Montague JR. Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. J Am Podiatr Med Assoc 1999;89(10):502-5.
  13. US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
  14. Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000).
  15. Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3
  16. Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4.
  17. Diebold R, Schopf B, Stammer H, Mendling W. Vaginal treatment with lactic acid gel delays relapses in recurrent urinary tract infections: results from an open, multicentre observational study. Arch Gynecol Obstet 2021;304(2):409-417.
  18. Khattar JA, Musharrafieh UM, Tamim H, Hamadeh GN. Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. Int J Dermatol 2007;46(4):427-30.
  19. Siskin SB, Quinlan PJ, Finkelstein MS, Marlucci M, Maglietta TG, Gibson JR. The effects of ammonium lactate 12% lotion versus no therapy in the treatment of dry skin of the heels. Int J Dermatol 1993;32(12):905-7.
  20. Robinson D, Friedmann D, Gordon J, Wortzman M, Nelson D. Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin. J Drugs Dermatol 2022;21(1):54-59.
  21. Emtestam L, Kaaman T, Rensfeldt K. Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24-week, double-blind, placebo-controlled study. Mycoses 2012;55(6):532-40.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single standard dose of lactic acid, because it is used in so many different ways. Skin products commonly contain a range of concentrations, and professional peels use stronger amounts applied by trained providers.

For any product, the best approach is to follow the label directions and start slowly to see how your skin reacts. For vaginal or oral products, use exactly as directed on the package.

Because the right amount depends on the product and your individual situation, check with a pharmacist or doctor if you are unsure how to use it safely.

Pregnancy & Breastfeeding

Lactic Acid & Pregnancy

Likely Safe

When used topically in appropriate concentrations . There is insufficient reliable information available about the safety of lactic acid when used orally during pregnancy and lactation; avoid using.

  1. Kempers S, Katz HI, Wildnauer R, Green B. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 1998;61:347-50.
  2. Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6.
  3. Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986;37:205-7, 209.
  4. Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989;21(4 Pt 1):714-6.
  5. Jennings MB, Logan L, Alfieri DM, Ross CF, Goodwin S, Lesczczynski C. A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. J Am Podiatr Med Assoc 2002;92(3):143-8.
  6. Dahl MV, Dahl AC. 12% lactate lotion for the treatment of xerosis. A double-blind clinical evaluation. Arch Dermatol 1983;119(1):27-30.
  7. Pham HT, Exelbert L, Segal-Owens AC, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48(5):30-6.
  8. Draelos ZD, Hall S, Munsick C. A 14-day Controlled Study Assessing Qualitative Improvement with 15% Lactic Acid and Ceramides in Skin Moisturization and Desquamation. J Clin Aesthet Dermatol 2020;13(8):E54-E58.
  9. Jennings MB, Alfieri D, Ward K, Lesczczynski C. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc 1998;88(7):332-6.
  10. Ademola J, Frazier C, Kim SJ, Theaux C, Saudez X. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol 2002;3(3):217-22.
  11. Jennings MB, Alfieri DM, Parker ER, Jackman L, Goodwin S, Lesczczynski C. A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. Cutis 2003;71
  12. Uy JJ, Joyce AM, Nelson JP, West B, Montague JR. Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. J Am Podiatr Med Assoc 1999;89(10):502-5.
  13. US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
  14. Robinson D, Friedmann D, Gordon J, Wortzman M, Nelson D. Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin. J Drugs Dermatol 2022;21(1):54-59.

Lactic Acid & Breastfeeding

Likely Safe

When used topically in appropriate concentrations . There is insufficient reliable information available about the safety of lactic acid when used orally during pregnancy and lactation; avoid using.

  1. Kempers S, Katz HI, Wildnauer R, Green B. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 1998;61:347-50.
  2. Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6.
  3. Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986;37:205-7, 209.
  4. Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989;21(4 Pt 1):714-6.
  5. Jennings MB, Logan L, Alfieri DM, Ross CF, Goodwin S, Lesczczynski C. A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. J Am Podiatr Med Assoc 2002;92(3):143-8.
  6. Dahl MV, Dahl AC. 12% lactate lotion for the treatment of xerosis. A double-blind clinical evaluation. Arch Dermatol 1983;119(1):27-30.
  7. Pham HT, Exelbert L, Segal-Owens AC, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48(5):30-6.
  8. Draelos ZD, Hall S, Munsick C. A 14-day Controlled Study Assessing Qualitative Improvement with 15% Lactic Acid and Ceramides in Skin Moisturization and Desquamation. J Clin Aesthet Dermatol 2020;13(8):E54-E58.
  9. Jennings MB, Alfieri D, Ward K, Lesczczynski C. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc 1998;88(7):332-6.
  10. Ademola J, Frazier C, Kim SJ, Theaux C, Saudez X. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol 2002;3(3):217-22.
  11. Jennings MB, Alfieri DM, Parker ER, Jackman L, Goodwin S, Lesczczynski C. A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. Cutis 2003;71
  12. Uy JJ, Joyce AM, Nelson JP, West B, Montague JR. Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. J Am Podiatr Med Assoc 1999;89(10):502-5.
  13. US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
  14. Robinson D, Friedmann D, Gordon J, Wortzman M, Nelson D. Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin. J Drugs Dermatol 2022;21(1):54-59.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 21 references that drive our Lactic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kempers S, Katz HI, Wildnauer R, Green B. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 1998;61:347-50.
  2. Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6.
  3. Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986;37:205-7, 209.
  4. Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000). DOI
  5. Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3 PubMed
  6. Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4. PubMed
  7. Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989;21(4 Pt 1):714-6. PubMed
  8. Jennings MB, Logan L, Alfieri DM, Ross CF, Goodwin S, Lesczczynski C. A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. J Am Podiatr Med Assoc 2002;92(3):143-8. PubMed
  9. Dahl MV, Dahl AC. 12% lactate lotion for the treatment of xerosis. A double-blind clinical evaluation. Arch Dermatol 1983;119(1):27-30. DOI
  10. Pham HT, Exelbert L, Segal-Owens AC, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48(5):30-6.
  11. Draelos ZD, Hall S, Munsick C. A 14-day Controlled Study Assessing Qualitative Improvement with 15% Lactic Acid and Ceramides in Skin Moisturization and Desquamation. J Clin Aesthet Dermatol 2020;13(8):E54-E58.
  12. Jennings MB, Alfieri D, Ward K, Lesczczynski C. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc 1998;88(7):332-6. PubMed
  13. Ademola J, Frazier C, Kim SJ, Theaux C, Saudez X. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol 2002;3(3):217-22. PubMed
  14. Jennings MB, Alfieri DM, Parker ER, Jackman L, Goodwin S, Lesczczynski C. A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. Cutis 2003;71
  15. Uy JJ, Joyce AM, Nelson JP, West B, Montague JR. Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. J Am Podiatr Med Assoc 1999;89(10):502-5. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Lactic Acid

145 brands in our database make a supplement containing Lactic Acid.

Product directory

Supplement products with Lactic Acid

780 products in our database contain Lactic Acid. Open any to see its full ingredient list and every drug interaction we check.

#NoFilter Natural Watermelon Passionfruit Flavor by N by Nutrilite Gummy Or Jelly 45 Gummy(ies) View ingredients & interactions 50 Plus Gummy Multivitamin Orange, Cherry & Berry by GNC Mega Men Gummy Or Jelly 120 Gummy(ies) View ingredients & interactions A.Vogel Molkosan by Bioforce Liquid 500 mL · 16.9 fl. Oz. View ingredients & interactions A.Vogel Molkosan by Bioforce Liquid 200 mL · 6.8 fl. Oz. View ingredients & interactions Ab Cuts Smart Gummies With CLA Fruit Punch by Corr-Jensen Gummy Or Jelly 60 Gummie(s) View ingredients & interactions Adult Fiber Gummies With Vitamin D by Vitamin World Gummy Or Jelly 75 Gummy(ies) View ingredients & interactions Adult Fiber Gummies with Vitamin D by Puritan's Pride Gummy Or Jelly 75 Gummie(s) View ingredients & interactions Adult Gummy B Complex Natural Wild Strawberry Flavor by Spring Valley Gummy Or Jelly 70 Gummie(s) View ingredients & interactions Adult Gummy Melatonin 5 mg Natural Strawberry Flavor by Spring Valley Gummy Or Jelly 60 Gummy(ies) View ingredients & interactions Adult Multi Gummies by Meijer Gummy Or Jelly 150 Gummy(ies) View ingredients & interactions Adult Multivatamin Gummy by Meijer Gummy Or Jelly 60 Gummy(ies) View ingredients & interactions Adult Multivitamin Gummies by Equate Gummy Or Jelly 150 Gummy(ies) View ingredients & interactions Adult Multivitamin Gummy by Meijer Gummy Or Jelly 150 Gummy(ies) View ingredients & interactions Adult Vitamin C Gummies 282 mg Natural Orange Flavor by up&up Gummy Or Jelly 150 Gummy Vitamin(s) View ingredients & interactions Adult's Gummy Multivitamin by up&up Gummy Or Jelly 70 Gummy Vitamin(s) View ingredients & interactions Adult's Gummy Multivitamin/Multimineral by up&up Gummy Or Jelly 100 Gummy Vitamin(s) View ingredients & interactions Adult's Gummy Multivitamins by up&up Gummy Or Jelly 150 Gummy Vitamin(s) View ingredients & interactions Adult's Multi Gummies Natural Fruit Flavor by Piping Rock Gummy Or Jelly 120 Gummy(ies) View ingredients & interactions Adults' Calcium Gummies 500 mg by up&up Gummy Or Jelly 100 Gummy Vitamin(s) View ingredients & interactions Adults' Calcium Gummies 500 mg by up&up Gummy Or Jelly 100 Gummy Vitamin(s) View ingredients & interactions Adults' Gummy Omega-3 Vitamin by up&up Gummy Or Jelly 120 Gummy Vitamin(s) View ingredients & interactions Adults' Multivitamin Gummies by up&up Gummy Or Jelly 150 Gummy Vitamin(s) View ingredients & interactions Advanced Hair, Skin & Nails Gummies Strawberry Flavored by Nature's Bounty Optimal Solutions Gummy Or Jelly 80 Gummy(ies) View ingredients & interactions Advanced Hair, Skin & Nails Strawberry Flavored Gummies by Nature's Bounty Optimal Solutions Gummy Or Jelly 40 Gummy(ies) View ingredients & interactions
Pharmacist Counseling Corner

Lactic Acid: Common Questions

What is Lactic Acid used for, and does it work?
People use Lactic Acid for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Lactic Acid for Dry skin. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Lactic Acid interact with prescription medications?
We do not currently list any known drug interactions for Lactic Acid. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Lactic Acid interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Lactic Acid with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Lactic Acid interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Lactic Acid used for?
It is most commonly used in skin products to exfoliate and moisturize, in some vaginal products to support normal pH, and as a natural part of fermented foods. Topical skin uses have the strongest evidence.
Is Lactic Acid safe?
For most people, Lactic Acid in foods and properly used skin products is safe. Stronger concentrations can irritate skin or mucous membranes, so follow directions and test sensitive areas first.
Does the Lactic Acid from exercise need a supplement to clear?
No. The Lactic Acid your muscles make during hard exercise clears on its own as you recover, and there is no good evidence that taking Lactic Acid supplements helps with this.
Can I use Lactic Acid products if I am pregnant?
Lactic Acid in foods is fine, but the safety of strong skin peels or vaginal products during pregnancy is not well studied, so check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Lactic Acid

A rotating sample of real supplements in our database that list Lactic Acid — open any to see its full ingredients and every drug interaction we check.

See all 780 products with Lactic Acid →
Where next
Supplement interaction checkerCheck any supplement or product against your medications Drug–drug interactionsCheck two or more of your medications against each other Browse medications A–ZEvery drug we’ve checked against herbs & supplements NDC & pricing lookupFind a drug’s NDCs, packaging and costs Ask a pharmacistFree, personal answer from our licensed team

Have a question about Lactic Acid?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist