Herb & supplement monograph

Osha Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Osha

0 medications have a known interaction with Osha, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Osha. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Osha combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Osha: Uses, Safety & Side Effects

The bottom line

Osha is a root from a wild mountain plant native to the western United States and Mexico, traditionally used by Native American and Hispanic communities for coughs, colds, and sore throats. Solid human research is lacking, so its benefits remain unproven, and it should be avoided during pregnancy and breastfeeding. Talk to your pharmacist or doctor before trying it.

Scientific name
Ligusticum porteri
Family
Apiaceae
Part used
Root
Common forms
Tea, tincture, capsules, lozenges, chewed raw root
People commonly use it for
  • Cough and sore throat
  • Respiratory infections and colds
  • Immune support
  • Digestive upset
  • Bronchitis and congestion

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited safety data exist, and wild osha can be confused with poisonous look-alike plants.

PregnancyLikely Unsafe

When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Osha (Ligusticum porteri) is a plant in the carrot and parsley family that grows in the high mountains of the western United States and Mexico. The part most people use is the root, which has a strong, spicy, celery-like smell.

Osha has a long history of use in Native American and Hispanic herbal traditions. People have used it for coughs, sore throats, colds, and other breathing problems, often by chewing the raw root or brewing it into tea.

Today osha is sold as a tea, tincture, capsule, lozenge, or dried root. Because it is mostly gathered from the wild and is difficult to grow on farms, supply can be limited and quality can vary.

How it works

Osha root contains a variety of plant compounds, including volatile oils (which give it its strong smell), phthalides, and other substances. In laboratory tests, some of these compounds have shown antioxidant or antimicrobial activity.

Supporters suggest osha may help soothe the throat and loosen mucus, but these ideas are mostly based on traditional use and early lab research, not on well-designed human studies.

In short, the proposed mechanisms are plausible but unproven. We do not have strong evidence showing exactly how osha affects the human body.

Effectiveness

Does Osha work?

Evidence overview · 2 uses evaluated
2 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Osha, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 2 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Dyspepsia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral osha for dyspepsia, there is insufficient reliable information about the clinical effects of osha for this purpose.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral osha for HIV/AIDS, there is insufficient reliable information about the clinical effects of osha for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Osha has been used for generations, but it has not been carefully studied for safety in modern research. One important concern is that osha grows in the wild alongside poison hemlock and water hemlock, which are highly toxic and can look similar. Buying from a trusted, reputable supplier helps lower this risk.

People with liver problems, kidney problems, or bleeding concerns should be cautious and check with a healthcare provider first. People allergic to plants in the carrot/parsley family (such as celery, carrot, or parsley) may also react to osha.

Pregnancy: Osha has traditionally been avoided during pregnancy, and there is no reliable safety data, so it should be avoided. Breastfeeding: There is not enough information to know if osha is safe while nursing, so it is best to avoid it.

Side effects

Because osha has not been well studied, its full side effect profile is not known. Reported or possible effects include stomach upset and allergic reactions, especially in people sensitive to related plants.

The most serious risk usually comes from misidentification—taking a toxic look-alike plant by mistake. Stop using osha and seek medical care if you have signs of an allergic reaction, such as a rash, swelling, or trouble breathing.

Dosing

There is no established standard dose for osha. The right amount depends on the form (tea, tincture, capsule, or lozenge) and the product's strength.

If you choose to use osha, follow the directions on the product label and do not exceed them. Because quality and potency vary between products, it is wise to talk with a pharmacist or doctor before starting, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Osha & Pregnancy

Likely Unsafe

When used orally. Osha has been used to stimulate menstruation and is reported to have abortifacient activity; contraindicated.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Osha & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Osha monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Osha

50 brands in our database make a supplement containing Osha.

Product directory

Supplement products with Osha

336 products in our database contain Osha. Open any to see its full ingredient list and every drug interaction we check.

Elderberry/Olive Syrup by Woodstock Herbal Products Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Fungal Fighter by Herb Stop Liquid 1 Ounce(s) · 30 mL View ingredients & interactions Ginger Wow!! Cough by L.A. Naturals Liquid 2 fl. Oz. · 59 mL View ingredients & interactions Ginger Zinger Bronchial Syrup by VitalBulk Liquid 4 fl. Oz. · 118 mL View ingredients & interactions Ginger Zinger Cough Syrup by Village Vitality Liquid 4 Fluid Ounce(s) · 118 mL View ingredients & interactions Ginger-Tussin Syrup by Designs for Health Liquid 4 fl. Oz. · 118 mL View ingredients & interactions Herbal CE I Elixir by Wise Woman Herbals Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Herbal CE II Elixir by Wise Woman Herbals Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Herbal Throat Spray by Source Naturals Wellness Liquid 1 fl. Oz. · 29.57 mL View ingredients & interactions Histoplex by Biotics Research Corporation Capsule 90 Capsule(s) View ingredients & interactions Immune Glycerite by Wise Woman Herbals Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Immune Support by Banyan Botanicals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Immuno-Bomb by Tonic Tinctures Liquid 1 fl. Oz. · 30 mL View ingredients & interactions ImmunoBoost by Herbs, Etc. Softgel Capsule 60 Fast-Acting Softgel(s) View ingredients & interactions ImmunoBoost by Herbs, Etc. Liquid 1 fl. Oz. · 29.6 mL View ingredients & interactions ImmunoBoost by Herbs Etc. Softgel Capsule 60 Softgel(s) View ingredients & interactions ImmunoBoost by Herbs Etc. Liquid 1 Fluid Ounce(s) · 30 Milliliter(s) View ingredients & interactions InstaClear Sinus Relief by Native Remedies Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Kick-Ass Immune Activator by WishGarden Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Kid-Biotics by L.A. Naturals Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Kid-Cough by L.A. Naturals Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Kid's Aller-Calm Alcohol Free by Thymely Solutions Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Kid's Biotic by Village Vitality Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Kid's Cough by Village Vitality Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions
Pharmacist Counseling Corner

Osha: Common Questions

What is Osha used for, and does it work?
People use Osha for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Osha interact with prescription medications?
We do not currently list any known drug interactions for Osha. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Osha interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Osha with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Osha interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Osha used for?
People most commonly use Osha for coughs, sore throats, colds, and other respiratory complaints, mainly based on Native American and Hispanic herbal traditions. Strong scientific proof that it works is lacking.
Is Osha safe to take?
Osha has a long history of use, but it has not been well studied for safety. A key concern is that wild Osha can be confused with poisonous look-alike plants, so buy only from reputable suppliers and talk to your pharmacist first.
Can I take Osha while pregnant or breastfeeding?
No. Osha has traditionally been avoided in pregnancy and lacks safety data for nursing, so it is best to avoid it during both pregnancy and breastfeeding.
How is Osha usually taken?
Osha is commonly taken as a tea, tincture, lozenge, or capsule, and the root is sometimes chewed directly. There is no standardized dose, so follow the product label and check with a healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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