Herb & supplement monograph

Witch Hazel Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Witch Hazel

0 medications have a known interaction with Witch Hazel, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Witch Hazel. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Witch Hazel combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Witch Hazel: Uses, Safety & Side Effects

The bottom line

Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a topical product for short-term use, but evidence for most uses is limited, and it should not be swallowed. Check with your pharmacist or doctor before using it, especially during pregnancy or breastfeeding.

Scientific name
Hamamelis virginiana
Family
Hamamelidaceae
Part used
Bark, leaves, and twigs
Common forms
Liquid astringent (distilled water), gels, ointments, creams, wipes/pads, suppositories, soaps
People commonly use it for
  • Skin irritation and inflammation
  • Hemorrhoids
  • Minor cuts and bruises
  • Oily or acne-prone skin
  • Itching and minor swelling
  • Soothing after shaving or sun exposure

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated on the skin short-term, but not meant to be taken by mouth.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Witch hazel is a remedy made from the bark, leaves, and twigs of the Hamamelis virginiana shrub, a plant native to eastern North America. It has been used in traditional and folk medicine for a very long time, mainly applied to the skin.

The most familiar form is the clear liquid sold in drugstores, often called witch hazel water or distilled witch hazel. It is also found in gels, creams, wipes, pads, and hemorrhoid products. People use it as an astringent, meaning it can make skin tissue feel tighter and help dry up minor weeping or irritation.

How it works

Witch hazel is rich in plant compounds called tannins, along with other substances like flavonoids and small amounts of volatile oils. Tannins are thought to be responsible for its astringent effect, helping tissues contract and reducing minor oozing.

Laboratory and animal research suggests witch hazel may have anti-inflammatory and antioxidant properties and may help tighten skin and small blood vessels. It is important to know that much of this is based on lab studies rather than large human trials, so the real-world benefits are not fully proven.

Note that distilled witch hazel water (the common drugstore product) contains little to no tannins, since they are largely removed during distillation, while alcohol is often added.

Effectiveness

Does Witch Hazel work?

Evidence overview · 12 uses evaluated
1 Possibly effective 1 Leans ineffective 10 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Topical witch hazel seems to relieve hemorrhoid symptoms.

Possibly Ineffective Atopic dermatitis (eczema)
Rating & evidence shown verbatim from Natural Medicines

Topical witch hazel does not appear to improve symptoms in patients with atopic dermatitis.

Also studied for 10 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for acne, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Bruises
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for bruises, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Burns
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for minor burns, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral and topical witch hazel for cancer, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Insect bite
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for insect bites, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Minor bleeding
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for minor bleeding, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Insufficient Reliable Evidence To Rate Postmenopausal conditions
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical witch hazel is beneficial for improving vaginal dryness in postmenopausal individuals.

Insufficient Reliable Evidence To Rate Skin irritation
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical witch hazel is beneficial for children with skin irritation.

Insufficient Reliable Evidence To Rate Sunburn
Rating & evidence shown verbatim from Natural Medicines

Small clinical studies suggest that topical witch hazel might reduce erythema after a sunburn.

Insufficient Reliable Evidence To Rate Varicose veins
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical witch hazel for varicose veins, there is insufficient reliable information about the clinical effects of witch hazel for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Witch hazel is generally considered safe for short-term use on the skin for most adults. It is intended for external use only and should not be swallowed, because the tannins it contains can upset the stomach and may be harmful in larger amounts.

People with very sensitive skin or known allergies to witch hazel should be cautious, and you should avoid using it on deep wounds, severe burns, or broken skin unless a doctor tells you to. Many liquid products also contain alcohol, which can dry out or sting the skin.

For pregnancy and breastfeeding, there is not enough reliable safety information. Topical use on small areas is likely low risk, but it is best to ask your doctor first, avoid taking it by mouth, and avoid applying it to the nipple area while nursing. Keep witch hazel products out of reach of children and away from the eyes.

Side effects

When used on the skin, witch hazel is usually well tolerated. The most common side effects are mild skin irritation, dryness, redness, or stinging, especially with alcohol-containing products or on sensitive areas.

Rarely, some people develop an allergic skin reaction (contact dermatitis) with itching, rash, or swelling. If this happens, stop using it. If swallowed, witch hazel may cause nausea, stomach upset, or, in large amounts, liver concerns from its tannin content. Seek medical help if a large amount is accidentally ingested.

Witch Hazel: Reported Adverse Effects

Documented safety reports on Witch Hazel from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Topically, witch hazel is generally well tolerated. Orally, witch hazel seems to be well tolerated at appropriate doses, but high doses may be associated with more adverse effects due to the tannin content in witch hazel.

Most Common Adverse Effects:

Topically: Contact dermatitis.

Serious Adverse Effects (Rare):

Orally: Kidney and liver damage when preparations containing at least 10% tannins are used in high doses.

Reports by condition
Cancer Oncologic

Witch hazel contains tannins, with the leaf containing 8% to 10% tannins and the bark containing up to 12% tannins. Some evidence suggests that tannins might cause cancer; other evidence shows tannins may prevent it. Regular consumption of herbs with high tannin concentrations correlates with increased incidence of esophageal or nasal cancer.

  1. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  2. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71.
  3. Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Dermatitis Dermatologic

Topically, witch hazel can cause contact dermatitis. A small number of people develop redness or burning.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410.
  3. Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for witch hazel. The right amount depends on the product and the form, such as a liquid, gel, pad, or ointment.

The safest approach is to follow the directions on the product label and use it only on the skin as directed. For hemorrhoid pads or creams, follow the package instructions. If you are unsure how often to use it or whether it is right for your situation, ask your pharmacist or doctor. Do not take witch hazel by mouth unless a healthcare professional specifically advises it.

Pregnancy & Breastfeeding

Witch Hazel & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Witch Hazel & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 7 references that drive our Witch Hazel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  4. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
  5. Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948. PubMed
  6. Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410. PubMed
  7. Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201 PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Witch Hazel

151 products in our database contain Witch Hazel. Open any to see its full ingredient list and every drug interaction we check.

Varicosil by Approved Science Capsule 45 Capsule(s) View ingredients & interactions Vasoflex Tablets by Kramer Novis Tablet Or Pill 120 Tablet(s) View ingredients & interactions VeinRid Premium by Premium Certified Capsule 45 Veggie Capsule(s) View ingredients & interactions Venoflash by Efficient Laboratories Tablet Or Pill 80 Tablet(s) View ingredients & interactions Venoflash Forte by Efficient Laboratories Tablet Or Pill 50 Tablet(s) View ingredients & interactions Venosan by GM Germa Tablet Or Pill 60 Tab(s) View ingredients & interactions Witch Hazel by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Witch Hazel by Herb Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbalist & Alchemist Liquid 2 fl. Oz. · 60 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Witch Hazel by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Witch Hazel by Herb Pharm Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Witch Hazel 500 mg by Nature's Answer Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Witch Hazel 500 mg by Nature's Answer Liquid 1 fl. Oz. · 30 mL View ingredients & interactions Witch Hazel Alcohol Free by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Witch Hazel Alcohol Free by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions
Pharmacist Counseling Corner

Witch Hazel: Common Questions

What is Witch Hazel used for, and does it work?
People use Witch Hazel for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Witch Hazel for Hemorrhoids. For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Witch Hazel interact with prescription medications?
We do not currently list any known drug interactions for Witch Hazel. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Witch Hazel interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Witch Hazel with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Witch Hazel interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Witch Hazel mainly used for?
It is most often used on the skin as an astringent for minor irritation, itching, bruises, oily skin, and hemorrhoids. Evidence for most uses is limited, but many people find it soothing for minor problems.
Can I drink or swallow Witch Hazel?
No. Witch Hazel is meant for external use on the skin only. Swallowing it can upset your stomach, and large amounts may be harmful, so keep it away from children.
Is Witch Hazel safe during pregnancy or breastfeeding?
There isn't enough reliable data to call it clearly safe. Topical use on a small area is likely low risk, but you should check with your doctor first and avoid taking it by mouth.
Why does Witch Hazel sometimes sting or dry out my skin?
Many liquid Witch Hazel products contain alcohol, which can cause stinging, dryness, or redness. If this bothers you, look for an alcohol-free version or stop using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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