Medication interaction hub

What Supplements Interact with Arsenic Trioxide (prescription drug)?

Arsenic Trioxide (prescription drug) brand name: Trisenox. Every interaction below applies to the brands too.

13 Interactions 6 Major 7 Moderate
Curated & coded by · Clinical Pharmacist · Updated October 4, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Arsenic Trioxide (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Arsenic Trioxide (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Every ingredient on this page interacts with arsenic trioxide (Trisenox) in the same way, by stretching the QT interval, the heart's electrical reset time, further than the drug already pushes it. Trisenox treats acute promyelocytic leukemia and prolongs the QT interval in up to 40 percent of patients all by itself, so anything that adds to that effect raises the odds of a dangerous heart rhythm. This list deserves genuine respect, and it includes grapefruit in large amounts alongside herbs like ephedra and cesium supplements.

People on Trisenox already get regular ECGs for exactly this reason, which is why these combinations belong in a conversation with the oncology team rather than an experiment at home. Of the 13 ingredients here, six carry a major rating and the other seven moderate, though the mechanism behind all of them is identical.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 7 No known interaction 1,439

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Arsenic Trioxide (prescription drug): Top Interactions at a Glance

The most significant Arsenic Trioxide (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 13 interacting ingredients — plus 1,439 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Arsenic Trioxide (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Arsenic + Arsenic Trioxide (prescription drug)i

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Arsenic Trioxide (prescription drug)i

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Arsenic Trioxide (prescription drug)i

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Grapefruit + Arsenic Trioxide (prescription drug)i

Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT interval-prolonging drug...

Read the full interaction Major Likelihood Probable Sida Cordifolia + Arsenic Trioxide (prescription drug)i

Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Read the full interaction Major Likelihood Possible American Hellebore + Arsenic Trioxide (prescription drug)i

American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (ECG).

Read the full interaction
The complete list

Every Supplement Checked Against Arsenic Trioxide (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 13 with a Arsenic Trioxide (prescription drug) interaction on file and 1,439 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Arsenic Trioxide (prescription drug)?

One-line answers, one card per combination — scroll through today’s 18 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Evodia with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Full Evodia + Arsenic Trioxide (prescription drug) answer

Can you take Iboga with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Arsenic Trioxide (prescription drug) answer

Can you take K2/spice with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Arsenic Trioxide (prescription drug) answer

Can you take Panax Ginseng with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng has an additive effect with drugs that prolong the QT interval and potentially increase the risk of ventricular...

Full Panax Ginseng + Arsenic Trioxide (prescription drug) answer

Can you take Puravive with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains Panax ginseng.

Full Puravive + Arsenic Trioxide (prescription drug) answer

Can you take Arsenic with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Arsenic Trioxide (prescription drug) answer

Can you take Cesium with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Arsenic Trioxide (prescription drug) answer

Can you take Ephedra with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Arsenic Trioxide (prescription drug) answer

Can you take Grapefruit with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT inte...

Full Grapefruit + Arsenic Trioxide (prescription drug) answer

Can you take Sida Cordifolia with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Arsenic Trioxide (prescription drug) answer

Can you take American Hellebore with Arsenic Trioxide (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Arsenic Trioxide (prescription drug) answer

Can you take Bitter Orange with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Arsenic Trioxide (prescription drug) answer

Can you take Cinchona with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Arsenic Trioxide (prescription drug) answer

Can you take Evodia with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might have an additive effect with drugs that prolong the QT interval, potentially increasing the risk of ventricular...

Full Evodia + Arsenic Trioxide (prescription drug) answer

Can you take Iboga with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Arsenic Trioxide (prescription drug) answer

Can you take K2/spice with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Arsenic Trioxide (prescription drug) answer

Can you take Panax Ginseng with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng has an additive effect with drugs that prolong the QT interval and potentially increase the risk of ventricular...

Full Panax Ginseng + Arsenic Trioxide (prescription drug) answer

Can you take Puravive with Arsenic Trioxide (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Puravive contains Panax ginseng.

Full Puravive + Arsenic Trioxide (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Arsenic Trioxide (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Arsenic Trioxide (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Arsenic Trioxide (prescription drug) sits in 1 interaction category. Open any one to see what the group means:

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Arsenic Trioxide (prescription drug) through this category.

About Arsenic Trioxide (prescription drug)

Arsenic Trioxide Injection is an intravenous (IV) cancer medicine used to treat acute promyelocytic leukemia (APL), both newly diagnosed low-risk disease and APL that has come back or stopped responding to other treatment.

Generic name: Arsenic Trioxide (prescription drug)  ·  Brand name: Trisenox.

See the full Arsenic Trioxide Injection drug information
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Take a Supplement Product? Check the Whole Bottle Against Arsenic Trioxide (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Arsenic Trioxide (prescription drug).

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Pharmacist Counseling Corner

Arsenic Trioxide (prescription drug) & Supplements: Common Questions

What supplements interact with Arsenic Trioxide (prescription drug)?
More than you might expect — 13 in total, though they are far from equal: 6 are rated major, 7 moderate, and 0 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Arsenic, Cesium, Ephedra.
Which Arsenic Trioxide (prescription drug) supplement interactions are the most serious?
The 6 major-rated combinations — led by Arsenic, Cesium, Ephedra, Grapefruit and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Arsenic Trioxide (prescription drug)?
Usually yes — most people on Arsenic Trioxide (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Trisenox have the same supplement interactions as Arsenic Trioxide (prescription drug)?
Yes — Trisenox all contain Arsenic Trioxide (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Arsenic Trioxide (prescription drug) and my other medications?
This page covers Arsenic Trioxide (prescription drug) against supplements and herbal ingredients. Checking Arsenic Trioxide (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Arsenic Trioxide Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 4, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.