Drug & supplement interaction

Hydrangea + Arsenic Trioxide (prescription drug)

Arsenic Trioxide (prescription drug) brand name: Trisenox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Hydrangea and Arsenic Trioxide (prescription drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Hydrangea and Arsenic Trioxide (prescription drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Arsenic Trioxide (prescription drug) and Hydrangea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Hydrangea safety at a glance

Hydrangea overall Use caution Human safety data are limited, and large or prolonged doses may cause unwanted effects.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Arsenic Trioxide (prescription drug) and Hydrangea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Arsenic Trioxide (prescription drug)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Arsenic Trioxide (prescription drug) is filed under a single classification — qt interval-prolonging drugs. Hydrangea has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Arsenic Trioxide (prescription drug)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Hydrangea Does Interact With Other Medications

Hydrangea has 1 moderate known drug interaction in our database — Arsenic Trioxide (prescription drug) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Arsenic Trioxide (prescription drug))
Taking anything else?

Check Another of Your Medications Against Hydrangea

Covers the 2,830 medications we’ve checked against Hydrangea. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Hydrangea and Arsenic Trioxide (prescription drug) May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness Additional detail

    Hydrangea

    “Orally, hydrangea may cause gastroenteritis, dizziness, and a feeling of tightness in the chest (4).”

    Hydrangea · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    “Orally, hydrangea may cause dizziness (4).”

    Hydrangea · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Arsenic Trioxide (prescription drug)

    Listed in the ADVERSE REACTIONS section of the FDA label for Arsenic Trioxide (prescription drug). Read the label on DailyMed ›

Effects for Arsenic Trioxide (prescription drug) come from the ADVERSE REACTIONS section of its FDA label; effects for Hydrangea come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Arsenic Trioxide (prescription drug)

This page covers Hydrangea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Arsenic Trioxide (prescription drug) page lists 13 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).

By severity: 6 major · 7 moderate.

From our pharmacist’s overview on the Arsenic Trioxide (prescription drug) page

“Every ingredient on this page interacts with arsenic trioxide (Trisenox) in the same way, by stretching the QT interval, the heart's electrical reset time, further than the drug already pushes it. Trisenox treats acute promyelocytic leukemia and prolongs the QT interval in up to 40 percent of patients all by itself, so anything that ad…”

Reviewed by 2 · Jul 18, 2026

Open the Arsenic Trioxide (prescription drug) interaction page

One more smart check

Taking Hydrangea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 337 real supplement products containing Hydrangea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hydrangea. Even though Hydrangea itself has no known interaction with Arsenic Trioxide (prescription drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hydrangea and Arsenic Trioxide (prescription drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hydrangea
Top 25%

#338 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Arsenic Trioxide (prescription drug)
Steady interest

#2,087 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Hydrangea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Hydrangea and Arsenic Trioxide (prescription drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Hydrangea

What is Hydrangea?

  • Kidney and bladder stones
  • Urinary tract complaints
  • Enlarged prostate symptoms
  • Mild diuretic (increasing urine)
  • Bladder infections (traditional use)

Hydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Because safety data are limited and large amounts may be harmful, it is best to talk with a pharmacist or doctor before using it.

Hydrangea arborescens · Hydrangeaceae · Root and rhizome (underground stem) · Dried root, tincture, liquid extract, capsules, tea

An interaction check asks whether these two react with each other — it does not ask whether Hydrangea is a good idea for someone in your situation. Here is what our Hydrangea record says about it on its own.

Hydrangea: dosing

There is no well-established or standardized dose for hydrangea, because it has not been studied carefully in people. Traditional preparations used the dried root as a tea or tincture, but reliable, specific amounts are not available.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Hydrangea monograph — the full record covers uses, side effects and every documented interaction.

Read the full Hydrangea monograph & all interactions
Medication

About Arsenic Trioxide Injection

What Is Arsenic Trioxide Injection Used For?

Brand name: Trisenox

Arsenic trioxide injection is used to treat acute promyelocytic leukemia (APL), a specific type of blood cancer. For adults newly diagnosed with low-risk APL that carries the t(15;17) chromosomal change or PML/RAR-alpha gene expression, it is given in combination with tretinoin.

It is also used on its own to bring about remission and then consolidate that response in patients with APL that has come back or stopped responding to retinoid and anthracycline chemotherapy — again, in patients whose APL has the t(15;17) translocation or PML/RAR-alpha gene expression.

See full Arsenic Trioxide Injection drug information
Keep checking

Other Drugs & Hydrangea

Browse every other medication we’ve checked against Hydrangea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Hydrangea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Hydrangea list.

See the full Hydrangea interactions page
See every supplement checked against Arsenic Trioxide (prescription drug), ranked by severity
Evidence & sources

Hydrangea References

The 1 references that drive our Hydrangea monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Hydrangea and Arsenic Trioxide (prescription drug) Together: Common Questions

Is it safe to take Hydrangea with Arsenic Trioxide (prescription drug)?
We do not list a known interaction between Hydrangea and Arsenic Trioxide (prescription drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Hydrangea and Arsenic Trioxide (prescription drug) have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Hydrangea and Arsenic Trioxide (prescription drug) combination checked?
Interactions in our licensed database are recorded against drug classes. Arsenic Trioxide (prescription drug) is filed under 1 classification, and Hydrangea has documented interactions with 1 drug class — none of Arsenic Trioxide (prescription drug)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Hydrangea interact with any other medications?
Yes. Hydrangea has 1 documented drug interaction in our database — Arsenic Trioxide (prescription drug) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Arsenic Trioxide (prescription drug) interact with any supplements?
Yes. Arsenic Trioxide (prescription drug) has documented interactions with 13 supplements in our database — Hydrangea is not one of them. The Arsenic Trioxide (prescription drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Hydrangea monograph Uses, safety profile, and every drug interaction in one place Arsenic Trioxide Injection drug information The full plain-English guide to this medication Arsenic Trioxide (prescription drug) supplement interactions Every supplement checked against Arsenic Trioxide (prescription drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Arsenic Trioxide (prescription drug) and Hydrangea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.