Medication interaction hub

What Supplements Interact with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn brand name: Rylaze. Every interaction below applies to the brands too.

38 Interactions 3 Major 35 Moderate
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rylaze (recombinant asparaginase erwinia chrysanthemi) is a chemotherapy drug for acute lymphoblastic leukemia, and because liver stress is one of its known side effects, this supplement list deserves genuine vigilance. All 38 ingredients on file interact the same way: each has its own potential to harm the liver, and layering that on top of asparaginase treatment raises the odds of real injury. Three entries carry a major rating, and two of them are simply alcohol, meaning beer and wine.

The other 35 are moderate, largely herbs with documented liver trouble behind them; kava alone has been linked to over 100 reported cases of liver toxicity. The liver already carries a heavy load during leukemia treatment, so hold off on any herbal product until your oncology team or pharmacist has reviewed it. On this page, nothing is harmless enough to skip that step.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 35 No known interaction 1,414

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn: Top Interactions at a Glance

The most significant Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 38 interacting ingredients — plus 1,414 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywni

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Beer + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywni

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction Major Likelihood Probable Wine + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywni

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn

All 1,452 ingredients in our database, ranked by severity — 38 with a Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn interaction on file and 1,414 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cassia Cinnamon with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Chaparral with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Comfrey with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Ephedra with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Epistane with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Fo-ti with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Garcinia with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.

Full Garcinia + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Gotu Kola with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Greater Celandine with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Hemp Agrimony with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Kava with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Khella with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Khella + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Kudzu with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Ligandrol with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Manchurian Thorn with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Niacin with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Noni with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Ostarine with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Padang Cassia with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer

Can you take Red Yeast Rice with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn sits in 1 interaction category. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn.

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Pharmacist Counseling Corner

Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn & Supplements: Common Questions

What supplements interact with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?
In our interaction database, 38 supplement and herbal ingredients have an interaction with Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn on file — 3 rated major, 35 moderate, and 0 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Beer, Wine.
Which Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur, Beer and Wine. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?
That depends entirely on which supplement. The honest answer for Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Rylaze have the same supplement interactions as Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn?
Yes — Rylaze all contain Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn and my other medications?
This page covers Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn against supplements and herbal ingredients. Checking Asparaginase Erwinia Chrysanthemi (Recombinant)-Rywn against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.