Medication interaction hub

What Supplements Interact with Clemastine Fumarate, Phenylpropanolamine?

Clemastine Fumarate, Phenylpropanolamine brand name: Tavist-D. Every interaction below applies to the brands too.

111 Interactions 7 Major 88 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 19, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Clemastine Fumarate, Phenylpropanolamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Clemastine Fumarate, Phenylpropanolamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tavist-D combines clemastine, a sedating antihistamine, with phenylpropanolamine, a stimulant decongestant, so supplements can pull it in either direction, and this list deserves genuine attention rather than a quick skim. Seven of the 111 ingredients on file rate major, and most of the trouble follows two patterns. Forty-four stimulant-type ingredients, ephedra among them but also everyday caffeine, can add to the decongestant and push blood pressure and heart rate too far. Another 30 have drying, sedating anticholinergic activity that piles drowsiness, dry mouth, and confusion on top of the antihistamine.

Eighty-eight entries rate moderate and 16 minor, many repeating those same themes at lower intensity, while 20 can add sun sensitivity. The odd one out is activated charcoal, a major entry for a different reason; it soaks up medicine in the gut and can blunt the dose itself, so space it well apart from when you take Tavist-D.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 88 Minor 16 No known interaction 1,341

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Clemastine Fumarate, Phenylpropanolamine: Top Interactions at a Glance

The most significant Clemastine Fumarate, Phenylpropanolamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 111 interacting ingredients — plus 1,341 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Clemastine Fumarate, Phenylpropanolamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Clemastine Fumarate, Phenylpropanolaminei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Clemastine Fumarate, Phenylpropanolaminei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Henbane + Clemastine Fumarate, Phenylpropanolaminei

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction Major Likelihood Probable Peyote + Clemastine Fumarate, Phenylpropanolaminei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Clemastine Fumarate, Phenylpropanolaminei

Theoretically, concomitant use might cause additive effects.

Read the full interaction Major Likelihood Probable Scopolia + Clemastine Fumarate, Phenylpropanolaminei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction
The complete list

Every Supplement Checked Against Clemastine Fumarate, Phenylpropanolamine

All 1,452 ingredients in our database, ranked by severity — 111 with a Clemastine Fumarate, Phenylpropanolamine interaction on file and 1,341 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Clemastine Fumarate, Phenylpropanolamine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Marshmallow with Clemastine Fumarate, Phenylpropanolamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Betel Nut with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro and animal research suggests that betel nut extract can inhibit acetylcholinesterase activity.

Full Betel Nut + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Black Tea with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Caffeine with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Chenopodium Oil with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Full Chenopodium Oil + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Chlorophyll with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Full Chlorophyll + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Chlorophyllin with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Full Chlorophyllin + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Cocoa with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Coffee with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Coffee Charcoal with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Cola Nut with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Datura Wrightii with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Datura wrightii contains atropine and scopolamine, as well as other tropane alkaloids with anticholinergic activity.

Full Datura Wrightii + Clemastine Fumarate, Phenylpropanolamine answer

Can you take European Mandrake with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Fever Bark with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Glucomannan with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Green Coffee with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Coffee + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Green Tea with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Green Tea + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Guarana with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.

Full Guarana + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Ilex Guayusa with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Ilex Guayusa + Clemastine Fumarate, Phenylpropanolamine answer

Can you take Masterwort with Clemastine Fumarate, Phenylpropanolamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effec...

Full Masterwort + Clemastine Fumarate, Phenylpropanolamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Clemastine Fumarate, Phenylpropanolamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Clemastine Fumarate, Phenylpropanolamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Clemastine Fumarate, Phenylpropanolamine sits in 6 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Clemastine Fumarate, Phenylpropanolamine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Clemastine Fumarate, Phenylpropanolamine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Clemastine Fumarate, Phenylpropanolamine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Clemastine Fumarate, Phenylpropanolamine through this category.

Phenylpropanolamine 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Clemastine Fumarate, Phenylpropanolamine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Clemastine Fumarate, Phenylpropanolamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Clemastine Fumarate, Phenylpropanolamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Clemastine Fumarate, Phenylpropanolamine.

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Pharmacist Counseling Corner

Clemastine Fumarate, Phenylpropanolamine & Supplements: Common Questions

What supplements interact with Clemastine Fumarate, Phenylpropanolamine?
Our database currently documents 111 ingredients with a known Clemastine Fumarate, Phenylpropanolamine interaction (7 major, 88 moderate, 16 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 111. The highest-ranked right now: Activated Charcoal, Ephedra, Henbane.
Which Clemastine Fumarate, Phenylpropanolamine supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Ephedra, Henbane, Peyote and Rauvolfia Vomitoria, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Clemastine Fumarate, Phenylpropanolamine?
Plenty of supplements coexist fine with Clemastine Fumarate, Phenylpropanolamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tavist-D have the same supplement interactions as Clemastine Fumarate, Phenylpropanolamine?
Yes — Tavist-D all contain Clemastine Fumarate, Phenylpropanolamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Clemastine Fumarate, Phenylpropanolamine and my other medications?
This page covers Clemastine Fumarate, Phenylpropanolamine against supplements and herbal ingredients. Checking Clemastine Fumarate, Phenylpropanolamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 19, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.