Medication interaction hub

What Supplements Interact with Fam-Trastuzumab, Deruxtecan-Nxki?

Fam-Trastuzumab, Deruxtecan-Nxki brand name: Enhertu. Every interaction below applies to the brands too.

37 Interactions 1 Major 28 Moderate 8 Minor
Curated & coded by · Clinical Pharmacist · Updated October 2, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fam-Trastuzumab, Deruxtecan-Nxki? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fam-Trastuzumab, Deruxtecan-Nxki against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Enhertu (fam-trastuzumab deruxtecan-nxki) is a targeted cancer treatment, and I read its supplement list with real seriousness. Every interacting ingredient on file acts on the same doorway, a transporter called P-glycoprotein that helps move the drug's chemotherapy payload in and out of cells. St. John's wort is the one to understand first, because it can speed the drug out of the body and leave you with less cancer-fighting effect than your oncologist intended. That risk is rated major.

Most of the rest lean the other way. Everyday items like ginger, green tea, and black pepper may slow that transporter and let drug levels climb, raising the odds of side effects rather than blunting the treatment. Given what this medicine is treating, tell your oncology team about every supplement you take. Among the 37 ingredients on file, only St. John's wort rates major; the rest divide into 28 moderate and eight minor entries.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 28 Minor 8 No known interaction 1,415

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fam-Trastuzumab, Deruxtecan-Nxki: Top Interactions at a Glance

The most significant Fam-Trastuzumab, Deruxtecan-Nxki supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 37 interacting ingredients — plus 1,415 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Fam-Trastuzumab, Deruxtecan-Nxki + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable St. John's Wort + Fam-Trastuzumab, Deruxtecan-Nxkii

St.

Read the full interaction
The complete list

Every Supplement Checked Against Fam-Trastuzumab, Deruxtecan-Nxki

All 1,452 ingredients in our database, ranked by severity — 37 with a Fam-Trastuzumab, Deruxtecan-Nxki interaction on file and 1,415 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fam-Trastuzumab, Deruxtecan-Nxki?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bitter Melon with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Rhodiola with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rhodiola might increase levels of P-glycoprotein substrates.

Full Rhodiola + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Sage with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase levels of drugs transported by P-glycoprotein.

Full Sage + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Schisandra with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Strawberry with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux.

Full Strawberry + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Sweet Orange with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.

Full Sweet Orange + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take White Pepper with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, white pepper might increase levels of p-glycoprotein substrates.

Full White Pepper + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Baikal Skullcap with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.

Full Baikal Skullcap + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Devil's Claw with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Grapefruit with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Grapefruit juice does not seem to affect renal P-glycoprotein (P-gp).

Full Grapefruit + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Puravive with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin.

Full Puravive + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Sesame with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, sesame might alter the transport of P-glycoprotein substrates.

Full Sesame + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Turmeric with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, turmeric might increase the absorption of P-glycoprotein substrates.

Full Turmeric + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Uva Ursi with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.

Full Uva Ursi + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Milk Thistle with Fam-Trastuzumab, Deruxtecan-Nxki?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, milk thistle might increase the absorption of P-glycoprotein substrates.

Full Milk Thistle + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take St. John's Wort with Fam-Trastuzumab, Deruxtecan-Nxki?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Goldenseal with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.

Full Goldenseal + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Black Pepper with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of P-glycoprotein substrates.

Full Black Pepper + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Bulbine Natalensis with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might increase the levels and clinical effects of p-glycoprotein substrates.

Full Bulbine Natalensis + Fam-Trastuzumab, Deruxtecan-Nxki answer

Can you take Cannabis with Fam-Trastuzumab, Deruxtecan-Nxki?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might alter levels of drugs that are substrates of P-glycoprotein (P-gp).

Full Cannabis + Fam-Trastuzumab, Deruxtecan-Nxki answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fam-Trastuzumab, Deruxtecan-Nxki is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fam-Trastuzumab, Deruxtecan-Nxki, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fam-Trastuzumab, Deruxtecan-Nxki sits in 1 interaction category. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Fam-Trastuzumab, Deruxtecan-Nxki through this category.

About Fam-Trastuzumab, Deruxtecan-Nxki

Fam-trastuzumab deruxtecan-nxki Injection is a HER2-targeted antibody-drug conjugate given by IV infusion to treat certain HER2-related breast, lung and gastric cancers, and some solid tumors.

Generic name: Fam-Trastuzumab, Deruxtecan-Nxki  ·  Brand name: Enhertu.

See the full Fam-trastuzumab deruxtecan-nxki Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fam-Trastuzumab, Deruxtecan-Nxki

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fam-Trastuzumab, Deruxtecan-Nxki.

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Products that contain Fam-Trastuzumab, Deruxtecan-Nxki-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Fam-Trastuzumab, Deruxtecan-Nxki.

Standardized St. John's Wort 600 mg by Nature's Truth contains St. John's Wort St. John's Wort-IMT by SP Standard Process contains St. John's Wort St John's Wort Extract by SuperSmart contains St. John's Wort St John's Wort 400 mg by Signature Supplements contains St. John's Wort Parabolish by Logos Nutritionals contains Goldenseal Immune Glycerite by Wise Woman Herbals contains Goldenseal Goldenseal by Herb Pharm contains Goldenseal Funga-Stop Formula by Woodstock Herbal Products contains Goldenseal Sweet Relief Glycogen Support Extreme by Justified Laboratories contains Bitter Melon Glucose Support by dr.bo contains Bitter Melon Glucofort Max by Justified Laboratories contains Bitter Melon Blood Sugar Manager by Nature's Way contains Bitter Melon Vitality by Transparent Labs contains Black Pepper Turmeric Extract 1,000 mg by Nature's Lab Gold contains Black Pepper Turmeric Curcumin Capsules by NutraChamps contains Black Pepper Turmeric Curcumin 1500 mg by O Orgeuos contains Black Pepper Bulasterone by HTP Hi-Tech Pharmaceuticals contains Bulbine Natalensis Dole Proof by 50CalLabz contains Bulbine Natalensis Black Ox by Enhanced contains Bulbine Natalensis Project Test by Anabolic Warfare contains Bulbine Natalensis
Pharmacist Counseling Corner

Fam-Trastuzumab, Deruxtecan-Nxki & Supplements: Common Questions

What supplements interact with Fam-Trastuzumab, Deruxtecan-Nxki?
In our interaction database, 37 supplement and herbal ingredients have an interaction with Fam-Trastuzumab, Deruxtecan-Nxki on file — 1 rated major, 28 moderate, and 8 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: St. John's Wort, Goldenseal, Bitter Melon.
Which Fam-Trastuzumab, Deruxtecan-Nxki supplement interactions are the most serious?
Focus on the major group: St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fam-Trastuzumab, Deruxtecan-Nxki?
That depends entirely on which supplement. The honest answer for Fam-Trastuzumab, Deruxtecan-Nxki is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Enhertu have the same supplement interactions as Fam-Trastuzumab, Deruxtecan-Nxki?
Yes — Enhertu all contain Fam-Trastuzumab, Deruxtecan-Nxki, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fam-Trastuzumab, Deruxtecan-Nxki and my other medications?
This page covers Fam-Trastuzumab, Deruxtecan-Nxki against supplements and herbal ingredients. Checking Fam-Trastuzumab, Deruxtecan-Nxki against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fam-trastuzumab deruxtecan-nxki Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 2, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.