Medication interaction hub

What Supplements Interact with Fluticasone Furoate, Umeclidinium, Vilanterol?

Fluticasone Furoate, Umeclidinium, Vilanterol brand name: Trelegy Ellipta. Every interaction below applies to the brands too.

195 Interactions 11 Major 145 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluticasone Furoate, Umeclidinium, Vilanterol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluticasone Furoate, Umeclidinium, Vilanterol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Trelegy Ellipta combines three medicines in one inhaler, a steroid plus two long-acting airway openers for COPD and asthma, and its interaction list earns real respect. Eleven of the 195 supplements on file carry a major rating, and the biggest cluster works through the CYP3A4 enzyme that processes the drug. Grapefruit can push its levels up, while St. John's wort can drive them down, opposite problems on the same pathway.

Other groups stack side effects instead. Some herbs, like henbane and scopolia, add to the drying, anticholinergic action of one component, a handful can lengthen the heart's QT interval (a rhythm disturbance risk), and heavy caffeine from coffee, tea, or cola can amplify the heart-stimulating pull of the beta-agonist. The 145 moderate and 39 minor entries matter less, but read the eleven major ones first, since those are where the real trouble sits.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 145 Minor 39 No known interaction 1,257

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Fluticasone Furoate, Umeclidinium, Vilanterol: Top Interactions at a Glance

The most significant Fluticasone Furoate, Umeclidinium, Vilanterol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 195 interacting ingredients — plus 1,257 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Fluticasone Furoate, Umeclidinium, Vilanterol + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Fluticasone Furoate, Umeclidinium, Vilanteroli

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Fluticasone Furoate, Umeclidinium, Vilanteroli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Fluticasone Furoate, Umeclidinium, Vilanteroli

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Cesium + Fluticasone Furoate, Umeclidinium, Vilanteroli

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.

Read the full interaction Major Likelihood Probable Ephedra + Fluticasone Furoate, Umeclidinium, Vilanteroli

Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Read the full interaction Major Likelihood Probable Henbane + Fluticasone Furoate, Umeclidinium, Vilanteroli

Concomitant use of henbane can have additive anticholinergic effects and adverse effects with amantadine, antihistamines, atropine, belladonna alkaloids, hyoscy...

Read the full interaction
The complete list

Every Supplement Checked Against Fluticasone Furoate, Umeclidinium, Vilanterol

All 1,452 ingredients in our database, ranked by severity — 195 with a Fluticasone Furoate, Umeclidinium, Vilanterol interaction on file and 1,257 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluticasone Furoate, Umeclidinium, Vilanterol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Vitamin E with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Neem with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Angel's Trumpet with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may increase anticholinergic effects and adverse effects.

Full Angel's Trumpet + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Astaxanthin with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Ayahuasca with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Bacopa with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Beet with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Berberine with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Beta-methylphenethylamine (bmpea) with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Bishop's Weed with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Bitter Orange with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Black Pepper with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Bog Labrador Tea with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Boswellia Serrata with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Boxwood with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity.

Full Boxwood + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Bulbine Natalensis with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Butternut with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Butternut has stimulant laxative effects.

Full Butternut + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Calamus with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Fluticasone Furoate, Umeclidinium, Vilanterol answer

Can you take Cannabis with Fluticasone Furoate, Umeclidinium, Vilanterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.

Full Cannabis + Fluticasone Furoate, Umeclidinium, Vilanterol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluticasone Furoate, Umeclidinium, Vilanterol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluticasone Furoate, Umeclidinium, Vilanterol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluticasone Furoate, Umeclidinium, Vilanterol sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

Corticosteroids 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Fluticasone Furoate, Umeclidinium, Vilanterol through this category.

About Fluticasone Furoate, Umeclidinium, Vilanterol

Fluticasone, umeclidinium, and vilanterol is a three-medicine inhaled combination used for the long-term maintenance treatment of COPD and asthma in adults.

Generic name: Fluticasone Furoate, Umeclidinium, Vilanterol  ·  Brand name: Trelegy Ellipta.

See the full Fluticasone, Umeclidinium, and Vilanterol Oral Inhalation drug information

Related: does Fluticasone Furoate, Umeclidinium, Vilanterol deplete any nutrients?

Fluticasone Furoate, Umeclidinium, Vilanterol has 8 reported nutrient associations in the research literature — see the Fluticasone Furoate, Umeclidinium, Vilanterol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluticasone Furoate, Umeclidinium, Vilanterol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluticasone Furoate, Umeclidinium, Vilanterol.

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Pharmacist Counseling Corner

Fluticasone Furoate, Umeclidinium, Vilanterol & Supplements: Common Questions

What supplements interact with Fluticasone Furoate, Umeclidinium, Vilanterol?
In our interaction database, 195 supplement and herbal ingredients have an interaction with Fluticasone Furoate, Umeclidinium, Vilanterol on file — 11 rated major, 145 moderate, and 39 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Fluticasone Furoate, Umeclidinium, Vilanterol supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Fluticasone Furoate, Umeclidinium, Vilanterol?
That depends entirely on which supplement. The honest answer for Fluticasone Furoate, Umeclidinium, Vilanterol is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Trelegy Ellipta have the same supplement interactions as Fluticasone Furoate, Umeclidinium, Vilanterol?
Yes — Trelegy Ellipta all contain Fluticasone Furoate, Umeclidinium, Vilanterol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Fluticasone Furoate, Umeclidinium, Vilanterol deplete any vitamins or nutrients?
It might — Fluticasone Furoate, Umeclidinium, Vilanterol has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Fluticasone Furoate, Umeclidinium, Vilanterol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Fluticasone Furoate, Umeclidinium, Vilanterol and my other medications?
This page covers Fluticasone Furoate, Umeclidinium, Vilanterol against supplements and herbal ingredients. Checking Fluticasone Furoate, Umeclidinium, Vilanterol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fluticasone, Umeclidinium, and Vilanterol Oral Inhalation drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.