Medication interaction hub

What Supplements Interact with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride brand name: Hycofenix. Every interaction below applies to the brands too.

241 Interactions 13 Major 190 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 26, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hycofenix combines guaifenesin with hydrocodone, an opioid, and pseudoephedrine, a decongestant, so supplements can collide with it from two directions at once. That is why this list of 241 ingredients deserves real caution, starting with the 13 rated major. The biggest danger sits with anything sedating: alcohol in any form heads that group, because piling sedation onto an opioid can slow breathing, not just deepen drowsiness. A smaller cluster of stimulant botanicals works the opposite way, amplifying pseudoephedrine's push on blood pressure and heart rate.

Grapefruit juice earns a major rating too, since it blocks the enzyme that clears hydrocodone and can raise its levels. Most of the 190 moderate entries are milder versions of those same two stories, and some are simply caffeine stacking stimulant effects on the decongestant. Another 38 rate minor, but if a supplement either sedates you or revs you up, assume this medication will feel it.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 190 Minor 38 No known interaction 1,211

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride: Top Interactions at a Glance

The Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 241 interacting ingredients — plus 1,211 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride Combinations Today

The Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Jackfruit + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.

Read the full interaction Moderate Likelihood Possible Ginger + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Major Likelihood Probable Kava + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction Major Likelihood Probable Sida Cordifolia + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction Moderate Likelihood Possible Sassafras + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Read the full interaction Moderate Likelihood Possible Zizyphus + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloridei

Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 241 with a Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interaction on file and 1,211 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Jackfruit with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.

Full Jackfruit + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Ginger with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Kava with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Sida Cordifolia with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of adverse cardiovascular effects when taken with stimulant drugs.

Full Sida Cordifolia + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Sassafras with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Peyote with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Full Peyote + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Rauvolfia Vomitoria with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take St. John's Wort with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Ayahuasca with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP2D6 substrates.

Full Ayahuasca + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Black Tea with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Black Tea + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Caffeine with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Cannabidiol (cbd) with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Cocoa with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Coffee with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Coffee Charcoal with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Cola Nut with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cola Nut + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take European Mandrake with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Fever Bark with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fever bark might increase or decrease the effects of stimulant drugs.

Full Fever Bark + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Glucomannan with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer

Can you take Goldenseal with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Goldenseal might increase serum levels of drugs metabolized by CYP2D6.

Full Goldenseal + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride.

Search a supplement product

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride & Supplements: Common Questions

What supplements interact with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?
In our interaction database, 241 supplement and herbal ingredients have an interaction with Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride on file — 13 rated major, 190 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?
That depends entirely on which supplement. The honest answer for Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Hycofenix have the same supplement interactions as Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride?
Yes — Hycofenix all contain Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride and my other medications?
This page covers Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride against supplements and herbal ingredients. Checking Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 26, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.