Medication interaction hub

What Supplements Interact with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Ketorolac Tromethamine, Phenylephrine Hydrochloride brand name: Omidria. Every interaction below applies to the brands too.

8 Interactions 2 Major 4 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ketorolac Tromethamine, Phenylephrine Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ketorolac Tromethamine, Phenylephrine Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Omidria is used during cataract surgery, combining phenylephrine to keep the pupil open and ketorolac, an NSAID, to control pain and inflammation. Its interaction list is short but not gentle. Of the eight supplement and herbal ingredients on file, two rate major, and both are alcohol: beer and wine combined with an NSAID raise the risk of stomach and intestinal bleeding.

The other six follow two threads. Half tie back to the ketorolac side, where a supplement may nudge the drug's levels up or, in chromium's case, the drug makes the body retain more of the mineral. Three topical products round out the list, able to change how much of a skin-applied medicine gets absorbed, a smaller worry for a drug used inside the eye. Four entries rate moderate and two minor, none close to the alcohol pairing in weight, so settle the drinking question with your surgical team before the procedure.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 4 Minor 2 No known interaction 1,444

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Ketorolac Tromethamine, Phenylephrine Hydrochloride: Top Interactions at a Glance

The most significant Ketorolac Tromethamine, Phenylephrine Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 8 highest-ranked of 8 interacting ingredients — plus 1,444 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Ketorolac Tromethamine, Phenylephrine Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Beer + Ketorolac Tromethamine, Phenylephrine Hydrochloridei

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction Major Likelihood Probable Wine + Ketorolac Tromethamine, Phenylephrine Hydrochloridei

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction
The complete list

Every Supplement Checked Against Ketorolac Tromethamine, Phenylephrine Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 8 with a Ketorolac Tromethamine, Phenylephrine Hydrochloride interaction on file and 1,444 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ketorolac Tromethamine, Phenylephrine Hydrochloride?

One-line answers, one card per combination — scroll through today’s 11 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Wine with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Wine + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Turpentine Oil with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Alchemilla with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Chromium with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. NSAIDs might increase chromium levels in the body.

Full Chromium + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Beer with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Beer + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Lithium with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking lithium supplements with NSAIDs might increase lithium levels and adverse effects.

Full Lithium + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Caprylic Acid with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Full Caprylic Acid + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Dimethylsulfoxide (dmso) with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Turpentine Oil with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Alchemilla with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer

Can you take Chromium with Ketorolac Tromethamine, Phenylephrine Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. NSAIDs might increase chromium levels in the body.

Full Chromium + Ketorolac Tromethamine, Phenylephrine Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ketorolac Tromethamine, Phenylephrine Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ketorolac Tromethamine, Phenylephrine Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ketorolac Tromethamine, Phenylephrine Hydrochloride sits in 2 interaction categories. Open any one to see what the group means:

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Ketorolac Tromethamine, Phenylephrine Hydrochloride through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ketorolac Tromethamine, Phenylephrine Hydrochloride through this category.

Related: does Ketorolac Tromethamine, Phenylephrine Hydrochloride deplete any nutrients?

Ketorolac Tromethamine, Phenylephrine Hydrochloride has 1 reported nutrient association in the research literature — see the Ketorolac Tromethamine, Phenylephrine Hydrochloride nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ketorolac Tromethamine, Phenylephrine Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ketorolac Tromethamine, Phenylephrine Hydrochloride.

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Products that contain Ketorolac Tromethamine, Phenylephrine Hydrochloride-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Ketorolac Tromethamine, Phenylephrine Hydrochloride.

Yeast-Cleanse by Solaray contains Caprylic Acid Yeast-Cleanse by Solaray contains Caprylic Acid Omega Cuts Elite by PMD contains Caprylic Acid Candida Support by Butterfly Express contains Caprylic Acid
Pharmacist Counseling Corner

Ketorolac Tromethamine, Phenylephrine Hydrochloride & Supplements: Common Questions

What supplements interact with Ketorolac Tromethamine, Phenylephrine Hydrochloride?
Our database currently documents 8 ingredients with a known Ketorolac Tromethamine, Phenylephrine Hydrochloride interaction (2 major, 4 moderate, 2 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 8. The highest-ranked right now: Beer, Wine, Lithium.
Which Ketorolac Tromethamine, Phenylephrine Hydrochloride supplement interactions are the most serious?
The 2 major-rated combinations — led by Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ketorolac Tromethamine, Phenylephrine Hydrochloride?
Plenty of supplements coexist fine with Ketorolac Tromethamine, Phenylephrine Hydrochloride; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Omidria have the same supplement interactions as Ketorolac Tromethamine, Phenylephrine Hydrochloride?
Yes — Omidria all contain Ketorolac Tromethamine, Phenylephrine Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ketorolac Tromethamine, Phenylephrine Hydrochloride deplete any vitamins or nutrients?
It might — Ketorolac Tromethamine, Phenylephrine Hydrochloride has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ketorolac Tromethamine, Phenylephrine Hydrochloride nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ketorolac Tromethamine, Phenylephrine Hydrochloride and my other medications?
This page covers Ketorolac Tromethamine, Phenylephrine Hydrochloride against supplements and herbal ingredients. Checking Ketorolac Tromethamine, Phenylephrine Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.