Medication interaction hub

What Supplements Interact with Levalbuterol?

Levalbuterol brand name: Xopenex. Every interaction below applies to the brands too.

15 Interactions 15 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Levalbuterol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Levalbuterol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Almost the entire interaction list for levalbuterol (Xopenex) comes down to caffeine. The inhaler already gives the heart a mild stimulant nudge while it opens the airways, and large amounts of caffeine, whether from everyday drinks or herbal energy ingredients, can amplify that push into a racing or pounding heartbeat. Ephedra raises the same concern without any caffeine involved. For most people these combinations are workable; the useful part is recognizing that heavy caffeine and a rescue dose land on the same system.

Sodium bicarbonate is the odd one out. In excess, think spoonfuls of baking soda taken regularly, it may deepen the drop in potassium that beta-agonists can cause. Nearly everything else is dose dependent, so easing back on caffeine usually settles the jitters. All 15 entries on file sit at moderate, with nothing rated major.

— , Clinical Pharmacist · July 18, 2026

Moderate 15 No known interaction 1,437

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Levalbuterol: Top Interactions at a Glance

The most significant Levalbuterol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 15 interacting ingredients — plus 1,437 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Levalbuterol + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Black Tea + Levalbuteroli

Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Caffeine + Levalbuteroli

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Cocoa + Levalbuteroli

Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Coffee + Levalbuteroli

Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Cola Nut + Levalbuteroli

Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Read the full interaction Moderate Likelihood Probable Ephedra + Levalbuteroli

Theoretically, large amounts of ephedra might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction
The complete list

Every Supplement Checked Against Levalbuterol

All 1,452 ingredients in our database, ranked by severity — 15 with a Levalbuterol interaction on file and 1,437 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Levalbuterol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Full Black Tea + Levalbuterol answer

Can you take Caffeine with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Full Caffeine + Levalbuterol answer

Can you take Cocoa with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Full Cocoa + Levalbuterol answer

Can you take Coffee with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Full Coffee + Levalbuterol answer

Can you take Cola Nut with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Full Cola Nut + Levalbuterol answer

Can you take Ephedra with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of ephedra might increase the cardiac inotropic effects of beta-agonists.

Full Ephedra + Levalbuterol answer

Can you take Green Coffee with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of green coffee might increase cardiac inotropic effects of beta-agonists.

Full Green Coffee + Levalbuterol answer

Can you take Green Tea with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea contains caffeine.

Full Green Tea + Levalbuterol answer

Can you take Guarana with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.

Full Guarana + Levalbuterol answer

Can you take Ilex Guayusa with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Ilex guayusa might increase cardiac inotropic effects of beta-agonists.

Full Ilex Guayusa + Levalbuterol answer

Can you take Oolong Tea with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of oolong tea might increase the cardiac inotropic effects of beta-agonists.

Full Oolong Tea + Levalbuterol answer

Can you take Pu-erh Tea with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of pu-erh tea might increase cardiac inotropic effects of beta-agonists.

Full Pu-erh Tea + Levalbuterol answer

Can you take Yerba Mate with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase the cardiac inotropic effects of beta-agonists, especially if taken in large amount...

Full Yerba Mate + Levalbuterol answer

Can you take Methylsynephrine with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has beta agonist activity.

Full Methylsynephrine + Levalbuterol answer

Can you take Sodium Bicarbonate with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients taking beta-adrenergic agonists.

Full Sodium Bicarbonate + Levalbuterol answer

Can you take Black Tea with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Full Black Tea + Levalbuterol answer

Can you take Caffeine with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Full Caffeine + Levalbuterol answer

Can you take Cocoa with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Full Cocoa + Levalbuterol answer

Can you take Coffee with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Full Coffee + Levalbuterol answer

Can you take Cola Nut with Levalbuterol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Full Cola Nut + Levalbuterol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Levalbuterol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Levalbuterol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Levalbuterol sits in 1 interaction category. Open any one to see what the group means:

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Levalbuterol through this category.

Related: does Levalbuterol deplete any nutrients?

Levalbuterol has 2 reported nutrient associations in the research literature — see the Levalbuterol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Levalbuterol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Levalbuterol.

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Pharmacist Counseling Corner

Levalbuterol & Supplements: Common Questions

What supplements interact with Levalbuterol?
More than you might expect — 15 in total, though they are far from equal: 0 are rated major, 15 moderate, and 0 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Black Tea, Caffeine, Cocoa.
Which Levalbuterol supplement interactions are the most serious?
None of the Levalbuterol supplement interactions on file are currently rated major. The most significant are the 15 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Levalbuterol?
Usually yes — most people on Levalbuterol can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Xopenex have the same supplement interactions as Levalbuterol?
Yes — Xopenex all contain Levalbuterol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Levalbuterol deplete any vitamins or nutrients?
It might — Levalbuterol has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Levalbuterol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Levalbuterol and my other medications?
This page covers Levalbuterol against supplements and herbal ingredients. Checking Levalbuterol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.