Medication interaction hub

What Supplements Interact with Metoproterenol?

Metoproterenol brand name: Alupent. Every interaction below applies to the brands too.

15 Interactions 15 Moderate
Curated & coded by · Clinical Pharmacist · Updated September 17, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Metoproterenol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Metoproterenol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Someone using metoproterenol (Alupent) for asthma or COPD is taking a beta-agonist, a drug that opens airways by stimulating the same receptors that speed the heart, and every one of the 15 supplement interactions on file works through that pathway. Twelve are caffeine sources, everyday things like coffee and tea, where large amounts can add to the drug's heart-stimulating effect. None of the 15 rates major; all sit at moderate, which makes this a watch-and-adjust list rather than a stop sign.

The three remaining entries deserve their own look. Ephedra and a similar stimulant sold in some weight-loss products act on beta receptors directly, and heavy sodium bicarbonate use (think tablespoons of baking soda daily) can pull potassium down, a risk beta-agonists already carry. If your heart pounds or flutters after a dose, tally your caffeine before assuming the medicine alone is responsible.

— , Clinical Pharmacist · July 18, 2026

Moderate 15 No known interaction 1,437

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Metoproterenol: Top Interactions at a Glance

The most significant Metoproterenol supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 15 interacting ingredients — plus 1,437 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Metoproterenol + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Black Tea + Metoproterenoli

Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Caffeine + Metoproterenoli

Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Cocoa + Metoproterenoli

Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Coffee + Metoproterenoli

Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Read the full interaction Moderate Likelihood Probable Cola Nut + Metoproterenoli

Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Read the full interaction Moderate Likelihood Probable Ephedra + Metoproterenoli

Theoretically, large amounts of ephedra might increase the cardiac inotropic effects of beta-agonists.

Read the full interaction
The complete list

Every Supplement Checked Against Metoproterenol

All 1,452 ingredients in our database, ranked by severity — 15 with a Metoproterenol interaction on file and 1,437 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Metoproterenol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ephedra with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of ephedra might increase the cardiac inotropic effects of beta-agonists.

Full Ephedra + Metoproterenol answer

Can you take Green Coffee with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of green coffee might increase cardiac inotropic effects of beta-agonists.

Full Green Coffee + Metoproterenol answer

Can you take Green Tea with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea contains caffeine.

Full Green Tea + Metoproterenol answer

Can you take Guarana with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.

Full Guarana + Metoproterenol answer

Can you take Ilex Guayusa with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Ilex guayusa might increase cardiac inotropic effects of beta-agonists.

Full Ilex Guayusa + Metoproterenol answer

Can you take Oolong Tea with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of oolong tea might increase the cardiac inotropic effects of beta-agonists.

Full Oolong Tea + Metoproterenol answer

Can you take Pu-erh Tea with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of pu-erh tea might increase cardiac inotropic effects of beta-agonists.

Full Pu-erh Tea + Metoproterenol answer

Can you take Yerba Mate with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in yerba mate might increase the cardiac inotropic effects of beta-agonists, especially if taken in large amount...

Full Yerba Mate + Metoproterenol answer

Can you take Methylsynephrine with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has beta agonist activity.

Full Methylsynephrine + Metoproterenol answer

Can you take Sodium Bicarbonate with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sodium bicarbonate may increase the risk for hypokalemia in patients taking beta-adrenergic agonists.

Full Sodium Bicarbonate + Metoproterenol answer

Can you take Black Tea with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of black tea might increase cardiac inotropic effects of beta-agonists.

Full Black Tea + Metoproterenol answer

Can you take Caffeine with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of caffeine might increase the cardiac inotropic effects of beta-agonists.

Full Caffeine + Metoproterenol answer

Can you take Cocoa with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of cocoa might increase the cardiac inotropic effects of beta-agonists.

Full Cocoa + Metoproterenol answer

Can you take Coffee with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.

Full Coffee + Metoproterenol answer

Can you take Cola Nut with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the caffeine in cola nut might increase the clinical effects of beta-adrenergic agonists.

Full Cola Nut + Metoproterenol answer

Can you take Ephedra with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of ephedra might increase the cardiac inotropic effects of beta-agonists.

Full Ephedra + Metoproterenol answer

Can you take Green Coffee with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of green coffee might increase cardiac inotropic effects of beta-agonists.

Full Green Coffee + Metoproterenol answer

Can you take Green Tea with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Green tea contains caffeine.

Full Green Tea + Metoproterenol answer

Can you take Guarana with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the clinical effects of beta-adrenergic agonists.

Full Guarana + Metoproterenol answer

Can you take Ilex Guayusa with Metoproterenol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Ilex guayusa might increase cardiac inotropic effects of beta-agonists.

Full Ilex Guayusa + Metoproterenol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Metoproterenol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Metoproterenol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Metoproterenol sits in 1 interaction category. Open any one to see what the group means:

Beta-Adrenergic Agonists 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Metoproterenol through this category.

About Metoproterenol

Metoproterenol is a prescription medication also sold under the brand name Alupent. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Metoproterenol  ·  Brand name: Alupent.

See the full Metaproterenol drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Metoproterenol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Metoproterenol.

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Pharmacist Counseling Corner

Metoproterenol & Supplements: Common Questions

What supplements interact with Metoproterenol?
Our database currently documents 15 ingredients with a known Metoproterenol interaction (0 major, 15 moderate, 0 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 15. The highest-ranked right now: Black Tea, Caffeine, Cocoa.
Which Metoproterenol supplement interactions are the most serious?
None of the Metoproterenol supplement interactions on file are currently rated major. The most significant are the 15 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Metoproterenol?
Plenty of supplements coexist fine with Metoproterenol; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Alupent have the same supplement interactions as Metoproterenol?
Yes — Alupent all contain Metoproterenol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Metoproterenol and my other medications?
This page covers Metoproterenol against supplements and herbal ingredients. Checking Metoproterenol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Metaproterenol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 17, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.